| Literature DB >> 26352792 |
Lan Ye1,2,3, Sarah K Fritschi1,2, Juliane Schelle1,2,3, Ulrike Obermüller1,2, Karoline Degenhardt1,2,3, Stephan A Kaeser1,2, Yvonne S Eisele1,2, Lary C Walker4, Frank Baumann1,2, Matthias Staufenbiel1,2, Mathias Jucker1,2.
Abstract
Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.Entities:
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Year: 2015 PMID： 26352792 DOI： 10.1038/nn.4117
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884