Literature DB >> 26350722

Biosimilar Insulin and Costs: What Can We Expect?

Lutz Heinemann1.   

Abstract

The costs for insulin treatment are high, and the steady increase in the number of patients with diabetes on insulin presents a true challenge to health care systems. Therefore, all measures to lower these costs are welcomed by patients, physicians, and health care providers. The market introduction of biosimilar insulins presents an option to lower treatment costs as biosimilars are usually offered at a lower price than the originator product. However, the assumption that a drastic reduction in insulin prices will take place, as was observed with many generic drugs, is most probably not realistic. As the first biosimilar insulin has now been approved in the EU, this commentary discusses a number of aspects that are relevant when it comes to the potential cost reduction we will see with the use of biosimilar insulins.
© 2015 Diabetes Technology Society.

Entities:  

Keywords:  biosimilar insulin; costs; diabetes therapy; economics; insulin therapy

Mesh:

Substances:

Year:  2015        PMID: 26350722      PMCID: PMC4773960          DOI: 10.1177/1932296815605337

Source DB:  PubMed          Journal:  J Diabetes Sci Technol        ISSN: 1932-2968


  9 in total

Review 1.  Biosimilar insulins: how similar is similar?

Authors:  Lutz Heinemann; Marcus Hompesch
Journal:  J Diabetes Sci Technol       Date:  2011-05-01

2.  Why is there no generic insulin? Historical origins of a modern problem.

Authors:  Jeremy A Greene; Kevin R Riggs
Journal:  N Engl J Med       Date:  2015-03-19       Impact factor: 91.245

Review 3.  The advent of biosimilars: challenges and risks.

Authors:  Rüdiger Müller; Christoph Renner; Cem Gabay; Giuseppe Cassata; Andreas Lohri; Paul Hasler
Journal:  Swiss Med Wkly       Date:  2014-07-01       Impact factor: 2.193

Review 4.  Ultrafast-acting insulins: state of the art.

Authors:  Lutz Heinemann; Douglas B Muchmore
Journal:  J Diabetes Sci Technol       Date:  2012-07-01

5.  Biosimilar Insulins: Basic Considerations.

Authors:  Lutz Heinemann; Marcus Hompesch
Journal:  J Diabetes Sci Technol       Date:  2014-01-01

6.  Patient Perspectives on Biosimilar Insulin.

Authors:  Alasdair R Wilkins; Manu V Venkat; Adam S Brown; Jessica P Dong; Nina A Ran; James S Hirsch; Kelly L Close
Journal:  J Diabetes Sci Technol       Date:  2014-01-01

Review 7.  An Overview of Current Regulatory Requirements for Approval of Biosimilar Insulins.

Authors:  Lutz Heinemann; Hootan Khatami; Ross McKinnon; Philip Home
Journal:  Diabetes Technol Ther       Date:  2015-03-19       Impact factor: 6.118

Review 8.  Biosimilar insulins: guidance for data interpretation by clinicians and users.

Authors:  L Heinemann; P D Home; M Hompesch
Journal:  Diabetes Obes Metab       Date:  2015-07-01       Impact factor: 6.577

Review 9.  Are biosimilars the next tool to guarantee cost-containment for pharmaceutical expenditures?

Authors:  María-Isabel Farfan-Portet; Sophie Gerkens; Isabelle Lepage-Nefkens; Irmgard Vinck; Frank Hulstaert
Journal:  Eur J Health Econ       Date:  2013-11-23
  9 in total
  10 in total

1.  Real-World Impact of Switching From Insulin Glargine (Lantus®) to Basaglar® and Potential Cost Saving in a Large Public Healthcare System in Saudi Arabia.

Authors:  Yazed AlRuthia; Ohud H Bahari; Suliman Alghnam; Ali M Alrumaih; Hassan Asiri; Mohammed Alshammari; Mansour Alhowimel; Hana A Al-Abdulkarim
Journal:  Front Public Health       Date:  2022-06-13

2.  If PBMs Guard Access to Drugs, Then Quis Custodiet Ipsos Custodies? (Who Will Guard the Guardians?).

Authors:  Alan W Carter; Lutz Heinemann
Journal:  J Diabetes Sci Technol       Date:  2016-11-01

Review 3.  Long-acting insulin analogues for type 1 diabetes: An overview of systematic reviews and meta-analysis of randomized controlled trials.

Authors:  Fernanda O Laranjeira; Keitty R C de Andrade; Ana C M G Figueiredo; Everton N Silva; Mauricio G Pereira
Journal:  PLoS One       Date:  2018-04-12       Impact factor: 3.240

Review 4.  Efficacy and safety of biosimilar insulins compared to their reference products: A systematic review.

Authors:  Carolyn Tieu; Eleanor J Lucas; Mindi DePaola; Lori Rosman; G Caleb Alexander
Journal:  PLoS One       Date:  2018-04-18       Impact factor: 3.240

5.  The value of fast-acting insulin aspart compared with insulin aspart for patients with diabetes mellitus treated with bolus insulin from a UK health care system perspective.

Authors:  Lalantha Leelarathna; Donna Ashley; Carrie Fidler; Witesh Parekh
Journal:  Ther Adv Endocrinol Metab       Date:  2018-04-04       Impact factor: 3.565

6.  Production costs and potential prices for biosimilars of human insulin and insulin analogues.

Authors:  Dzintars Gotham; Melissa J Barber; Andrew Hill
Journal:  BMJ Glob Health       Date:  2018-09-25

7.  Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure.

Authors:  Roman V Drai; Tatiana L Karonova; Alexander Y Mayorov; Igor E Makarenko; Artem R Dorotenko; Viktoria S Kulesh; Vladislav V Kovalik; Alena T Andreeva
Journal:  Clin Pharmacol Drug Dev       Date:  2022-03-01

8.  How Similar Are Biosimilars? What Do Clinicians Need to Know About Biosimilar and Follow-On Insulins?

Authors:  Curtis Triplitt; Debbie Hinnen; Virginia Valentine
Journal:  Clin Diabetes       Date:  2017-10

Review 9.  Identifying Key Benefits in European Off-Patent Biologics and Biosimilar Markets: It is Not Only About Price!

Authors:  Binita Dutta; Isabelle Huys; Arnold G Vulto; Steven Simoens
Journal:  BioDrugs       Date:  2020-04       Impact factor: 5.807

10.  A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies.

Authors:  Irina Dyukova; Ahmed Ben Faleh; Stephan Warnke; Natalia Yalovenko; Vasyl Yatsyna; Priyanka Bansal; Thomas R Rizzo
Journal:  Analyst       Date:  2021-07-26       Impact factor: 4.616

  10 in total

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