| Literature DB >> 26350265 |
Daniel Bertin1,2, Sylvain Dubucquoi3,4,5, Daniela Lakomy6, Anne-Sophie Deleplancque3, Sophie Desplat-Jégo7,8.
Abstract
Autoantibodies are a common feature of rheumatoid arthritis (RA), and their detection is used as a diagnostic tool in medical practice. Rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) detection in patients' sera are now included in 2010 ACR/EULAR criteria for RA diagnosis. In this study, we evaluated a new vimentin-derived ACPA ELISA, the anti-cyclic citrullinated peptide high sensitive (CCP hs) test, and we compared its performance with the RF IgM and anti-CCP3 tests on a French multicenter cohort of 84 RA patients, 107 non-RA patients and 100 healthy controls. Sensitivities for RA diagnosis were 71.4, 84.5 and 64.3 % and specificities were 88.4, 86.9 and 87.3 % for CCP hs, CCP3 and RF IgM, respectively. There was a moderate correlation between CCP hs and CCP3 titers (Pearson's r = 0.43; p < 0.0001). These results support the contention that anti-CCP hs antibodies are new reliable ACPA with high specificity for RA.Entities:
Keywords: ACPA; Anti-CCP antibodies; Anti-citrullinated protein antibodies; CCP hs (high sensitive); Rheumatoid arthritis
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Year: 2016 PMID： 26350265 DOI： 10.1007/s12026-015-8690-9
Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829