Gudmundur Skarphedinsson1, Bernhard Weidle2, Tord Ivarsson1. 1. 1 Center for Child and Adolescent Mental Health , Eastern and Southern Norway, Oslo, Norway . 2. 2 Norwegian University of Science and Technology, Faculty of Medicine, Regional Center for Child and Youth Mental Health and Child Welfare , Trondheim, Norway .
Abstract
OBJECTIVE: The purpose of this study was to investigate the effect of sertraline (SRT) in children and adolescents with obsessive-compulsive disorder (OCD) who did not respond to two consecutive courses of cognitive-behavior therapy (CBT). METHODS: Observational study with 11 participants (males, n=6), 7-17 years of age with Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) primary OCD. All had received 14 plus 10 sessions of CBT over the course of 218-532 days (mean=342.2, SD=85.5). Outcome measures were mean reduction of the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) total score and adequate clinical response (CY-BOCS<16). All participants received SRT (maximum dose 200 mg/day). The study was a part of the Nordic Long-Term OCD Treatment Study (NordLOTS). RESULTS: Participants were treated with SRT over 72-300 days (mean=164.2, SD=68.3). The mean CY-BOCS score was reduced from 21.5 (SD=2.6) to 17.5 (SD=3.3). Only three participants obtained adequate clinical response (27.2%), and only two obtained >25% CY-BOCS total score reduction (close to 50%). CONCLUSIONS: A clinical response in approximately one third of the participants suggests that SRT treatment might be beneficial to a minority of patients who have consistently failed CBT.
RCT Entities:
OBJECTIVE: The purpose of this study was to investigate the effect of sertraline (SRT) in children and adolescents with obsessive-compulsive disorder (OCD) who did not respond to two consecutive courses of cognitive-behavior therapy (CBT). METHODS: Observational study with 11 participants (males, n=6), 7-17 years of age with Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) primary OCD. All had received 14 plus 10 sessions of CBT over the course of 218-532 days (mean=342.2, SD=85.5). Outcome measures were mean reduction of the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) total score and adequate clinical response (CY-BOCS<16). All participants received SRT (maximum dose 200 mg/day). The study was a part of the Nordic Long-Term OCD Treatment Study (NordLOTS). RESULTS:Participants were treated with SRT over 72-300 days (mean=164.2, SD=68.3). The mean CY-BOCS score was reduced from 21.5 (SD=2.6) to 17.5 (SD=3.3). Only three participants obtained adequate clinical response (27.2%), and only two obtained >25% CY-BOCS total score reduction (close to 50%). CONCLUSIONS: A clinical response in approximately one third of the participants suggests that SRT treatment might be beneficial to a minority of patients who have consistently failed CBT.
Authors: M F Flament; A Whitaker; J L Rapoport; M Davies; C Z Berg; K Kalikow; W Sceery; D Shaffer Journal: J Am Acad Child Adolesc Psychiatry Date: 1988-11 Impact factor: 8.829
Authors: Fernando Ramos Asbahr; Ana Regina Castillo; Ligia Montenegro Ito; Maria Rosário Dias de Oliveira Latorre; Michele Nunes Moreira; Francisco Lotufo-Neto Journal: J Am Acad Child Adolesc Psychiatry Date: 2005-11 Impact factor: 8.829
Authors: Eric A Storch; Tanya K Murphy; Gary R Geffken; Ohel Soto; Muhammad Sajid; Pam Allen; Jonathan W Roberti; Erin M Killiany; Wayne K Goodman Journal: Psychiatry Res Date: 2004-11-30 Impact factor: 3.222
Authors: L A Valleni-Basile; C Z Garrison; K L Jackson; J L Waller; R E McKeown; C L Addy; S P Cuffe Journal: J Am Acad Child Adolesc Psychiatry Date: 1994 Jul-Aug Impact factor: 8.829
Authors: W K Goodman; L H Price; S A Rasmussen; C Mazure; R L Fleischmann; C L Hill; G R Heninger; D S Charney Journal: Arch Gen Psychiatry Date: 1989-11
Authors: Jason Gallant; Eric A Storch; Lisa J Merlo; Emily D Ricketts; Gary R Geffken; Wayne K Goodman; Tanya K Murphy Journal: J Anxiety Disord Date: 2008-02-07
Authors: Nor Christian Torp; Kitty Dahl; Gudmundur Skarphedinsson; Per Hove Thomsen; Robert Valderhaug; Bernhard Weidle; Karin Holmgren Melin; Katja Hybel; Judit Becker Nissen; Fabian Lenhard; Tore Wentzel-Larsen; Martin E Franklin; Tord Ivarsson Journal: Behav Res Ther Date: 2014-11-21
Authors: Sanne Jensen; Katja A Hybel; Davíð R M A Højgaard; Judith Becker Nissen; Bernhard Weidle; Tord Ivarsson; Gudmundur Skarphedinsson; Karin Melin; Nor Christian Torp; Anders Helles Carlsen; Erik Lykke Mortensen; Fabian Lenhard; Scott Compton; Per Hove Thomsen Journal: Eur Child Adolesc Psychiatry Date: 2021-04-21 Impact factor: 5.349