Literature DB >> 26347034

Alpha-synuclein propagation: New insights from animal models.

Benjamin Dehay1,2, Miquel Vila3,4,5, Erwan Bezard1,2, Patrik Brundin6, Jeffrey H Kordower7.   

Abstract

Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates cell-to-cell transmission of misfolded alpha-synuclein as a common pathogenetic mechanism in synucleinopathies. The impact of alpha-synuclein pathology on neuronal dysfunction and behavioral impairments is being explored in animal models. This review provides an update on how research in animal models supports the concept that misfolded alpha-synuclein spreads from cell to cell and describes how findings in animal models might relate to the disease process in humans. Finally, we discuss the current underlying molecular and cellular mechanisms and future therapeutic strategies targeting alpha-synuclein propagation.
© 2015 International Parkinson and Movement Disorder Society.

Entities:  

Keywords:  Parkinson's disease; alpha-synuclein; animal models; propagation; synucleinopathy

Mesh：

Substances：

Year:  2015        PMID： 26347034     DOI： 10.1002/mds.26370

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  44 in total

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