Literature DB >> 26343953

Experimental cancer cachexia: Evolving strategies for getting closer to the human scenario.

Fabio Penna1, Sílvia Busquets2, Josep M Argilés3.   

Abstract

Cancer cachexia is a frequent syndrome that dramatically affects patient quality of life, anti-cancer treatment effectiveness, and overall survival. To date, no effective treatment is available and most of the studies are performed in experimental models in order to uncover the underlying mechanisms and to design prospective therapeutic strategies. This review summarizes the most relevant information regarding the use of animal models for studying cancer cachexia. Technical limitations and degree of recapitulation of the features of human cachexia are highlighted, in order to help investigators choose the most suitable model according to study-specific endpoints.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cancer cachexia; Experimental model; Muscle wasting; Preclinical; Translational

Mesh：

Year:  2015        PMID： 26343953     DOI： 10.1016/j.semcdb.2015.09.002

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  27 in total

1.  Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes.

Authors:  Song Gao; James A Carson
Journal:  Am J Physiol Cell Physiol       Date:  2015-10-21       Impact factor: 4.249

2.  Effects of conditioned media from murine lung cancer cells and human tumor cells on cultured myotubes.

Authors:  Blas A Guigni; Jos van der Velden; C Matthew Kinsey; James A Carson; Michael J Toth
Journal:  Am J Physiol Endocrinol Metab       Date:  2019-11-05       Impact factor: 4.310

Review 3.  Understanding cachexia in the context of metastatic progression.

Authors:  Anup K Biswas; Swarnali Acharyya
Journal:  Nat Rev Cancer       Date:  2020-03-31       Impact factor: 60.716

Review 4.  The Etiology and Impact of Muscle Wasting in Metastatic Cancer.

Authors:  Anup K Biswas; Swarnali Acharyya
Journal:  Cold Spring Harb Perspect Med       Date:  2020-10-01       Impact factor: 5.159

5.  Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.

Authors:  Elena Conte; Giulia Maria Camerino; Antonietta Mele; Michela De Bellis; Sabata Pierno; Francesco Rana; Adriano Fonzino; Roberta Caloiero; Laura Rizzi; Elena Bresciani; Khoubaib Ben Haj Salah; Jean-Alain Fehrentz; Jean Martinez; Arcangela Giustino; Maria Addolorata Mariggiò; Mauro Coluccia; Domenico Tricarico; Marcello Diego Lograno; Annamaria De Luca; Antonio Torsello; Diana Conte; Antonella Liantonio
Journal:  J Cachexia Sarcopenia Muscle       Date:  2017-03-10       Impact factor: 12.910

Review 6.  Cancer-induced muscle wasting: latest findings in prevention and treatment.

Authors:  Zaira Aversa; Paola Costelli; Maurizio Muscaritoli
Journal:  Ther Adv Med Oncol       Date:  2017-03-08       Impact factor: 8.168

7.  Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.

Authors:  Gang Wang; Anup K Biswas; Wanchao Ma; Manoj Kandpal; Courtney Coker; Paul M Grandgenett; Michael A Hollingsworth; Rinku Jain; Kurenai Tanji; Sara Lόpez-Pintado; Alain Borczuk; Doreen Hebert; Supak Jenkitkasemwong; Shintaro Hojyo; Ramana V Davuluri; Mitchell D Knutson; Toshiyuki Fukada; Swarnali Acharyya
Journal:  Nat Med       Date:  2018-06-06       Impact factor: 53.440

Review 8.  Ghrelin for the management of cachexia associated with cancer.

Authors:  Mahalaqua Nazli Khatib; Anuraj H Shankar; Richard Kirubakaran; Abhay Gaidhane; Shilpa Gaidhane; Padam Simkhada; Zahiruddin Quazi Syed
Journal:  Cochrane Database Syst Rev       Date:  2018-02-28

9.  Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.

Authors:  Giuseppe Sirago; Elena Conte; Flavio Fracasso; Antonella Cormio; Jean-Alain Fehrentz; Jean Martinez; Clara Musicco; Giulia Maria Camerino; Adriano Fonzino; Laura Rizzi; Antonio Torsello; Angela Maria Serena Lezza; Antonella Liantonio; Palmiro Cantatore; Vito Pesce
Journal:  Sci Rep       Date:  2017-10-12       Impact factor: 4.379

10.  Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture.

Authors:  Robert W Jackman; Jess Floro; Rei Yoshimine; Brian Zitin; Maythita Eiampikul; Kahlid El-Jack; Danielle N Seto; Susan C Kandarian
Journal:  Front Physiol       Date:  2017-09-25       Impact factor: 4.566
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