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Literature DB >> 26343880

Gut Microbiota Dysbiosis in Obesity-Linked Metabolic Diseases and Prebiotic Potential of Polyphenol-Rich Extracts.

Fernando F Anhê^1,2,3, Thibault V Varin⁴, Mélanie Le Barz^5,6,7, Yves Desjardins⁸, Emile Levy^9,10,11, Denis Roy¹², André Marette^13,14,15.

Abstract

Trillions of microorganisms inhabit the human body, strongly colonizing the gastro-intestinal tract and outnumbering our own cells. High-throughput sequencing techniques and new bioinformatic tools have enabled scientists to extend our knowledge on the relationship between the gut microbiota and host's physiology. Disruption of the ecological equilibrium in the gut (i.e., dysbiosis) has been associated with several pathological processes, including obesity and its related comorbidities, with diet being a strong determinant of gut microbial balance. In this review, we discuss the potential prebiotic effect of polyphenol-rich foods and extracts and how they can reshape the gut microbiota, emphasizing the novel role of the mucin-degrading bacterium Akkermansia muciniphila in their metabolic benefits.

Entities: Chemical Disease Species

Keywords: Akkermansia; Insulin resistance; Obesity; Polyphenols; Prebiotics

Mesh：

Substances：

Year: 2015 PMID： 26343880 DOI： 10.1007/s13679-015-0172-9

Source DB: PubMed Journal: Curr Obes Rep ISSN： 2162-4968

96 in total

1. Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice.

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Journal: Biochem Biophys Res Commun Date: 2006-04-05 Impact factor: 3.575

2. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.

Authors: Yukihiro Furusawa; Yuuki Obata; Shinji Fukuda; Takaho A Endo; Gaku Nakato; Daisuke Takahashi; Yumiko Nakanishi; Chikako Uetake; Keiko Kato; Tamotsu Kato; Masumi Takahashi; Noriko N Fukuda; Shinnosuke Murakami; Eiji Miyauchi; Shingo Hino; Koji Atarashi; Satoshi Onawa; Yumiko Fujimura; Trevor Lockett; Julie M Clarke; David L Topping; Masaru Tomita; Shohei Hori; Osamu Ohara; Tatsuya Morita; Haruhiko Koseki; Jun Kikuchi; Kenya Honda; Koji Hase; Hiroshi Ohno
Journal: Nature Date: 2013-11-13 Impact factor: 49.962

3. Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats.

Authors: Katheryn M Goodrich; Gabrielle Fundaro; Laura E Griffin; Ar'quette Grant; Matthew W Hulver; Monica A Ponder; Andrew P Neilson
Journal: Nutr Res Date: 2012-10-15 Impact factor: 3.315

4. Radiolabelled cyanidin 3-O-glucoside is poorly absorbed in the mouse.

Authors: Catherine Felgines; Stéphanie Krisa; Aurélie Mauray; Catherine Besson; Jean-Louis Lamaison; Augustin Scalbert; Jean-Michel Mérillon; Odile Texier
Journal: Br J Nutr Date: 2010-02-26 Impact factor: 3.718

5. Effects of healthy dietary pattern and other lifestyle factors on incidence of diabetes in a rural Japanese population.

Authors: Akiko Morimoto; Yuko Ohno; Yukako Tatsumi; Shoichi Mizuno; Shaw Watanabe
Journal: Asia Pac J Clin Nutr Date: 2012 Impact factor: 1.662

6. Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.

Authors: Takuya Suzuki; Hiroshi Hara
Journal: J Nutr Date: 2009-03-18 Impact factor: 4.798

Review 7. The core gut microbiome, energy balance and obesity.

Authors: Peter J Turnbaugh; Jeffrey I Gordon
Journal: J Physiol Date: 2009-06-02 Impact factor: 5.182

8. Soft drink, 100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus.

Authors: Ehab S Eshak; Hiroyasu Iso; Tetsuya Mizoue; Manami Inoue; Mitsuhiko Noda; Shoichiro Tsugane
Journal: Clin Nutr Date: 2012-08-13 Impact factor: 7.324

Review 9. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review.

Authors: Aleksandra Duda-Chodak; Tomasz Tarko; Paweł Satora; Paweł Sroka
Journal: Eur J Nutr Date: 2015-02-12 Impact factor: 5.614

10. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome.

Authors: Benoit Chassaing; Omry Koren; Julia K Goodrich; Angela C Poole; Shanthi Srinivasan; Ruth E Ley; Andrew T Gewirtz
Journal: Nature Date: 2015-02-25 Impact factor: 49.962

48 in total

Review 1. Potential Health Benefits of Combining Yogurt and Fruits Based on Their Probiotic and Prebiotic Properties.

Authors: Melissa Anne Fernandez; André Marette
Journal: Adv Nutr Date: 2017-01-17 Impact factor: 8.701

2. Intestinal Microbiome, Akkermansia muciniphila, and Medical Nutrition Therapy.

Authors: Jeffrey Bland
Journal: Integr Med (Encinitas) Date: 2016-10

Review 3. Progress of analytical tools and techniques for human gut microbiome research.

Authors: Eun-Ji Song; Eun-Sook Lee; Young-Do Nam
Journal: J Microbiol Date: 2018-09-28 Impact factor: 3.422

4. Proanthocyanidins of Natural Origin: Molecular Mechanisms and Implications for Lipid Disorder and Aging-Associated Diseases.

Authors: Yu Nie; Stephen R Stürzenbaum
Journal: Adv Nutr Date: 2019-05-01 Impact factor: 8.701