Sindhu Lakkur1, Suzanne Judd2, Roberd M Bostick3, William McClellan4, W Dana Flanders5, Victoria L Stevens6, Michael Goodman3. 1. Department of Nutrition, Emory University, Atlanta, GA, USA; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: slakkur@uab.edu. 2. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA. 3. Department of Nutrition, Emory University, Atlanta, GA, USA; Department of Epidemiology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA. 4. Department of Epidemiology, Emory University, Atlanta, GA, USA. 5. Department of Epidemiology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA. 6. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Abstract
OBJECTIVE: To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. METHODS: Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3-26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. RESULTS: The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38-0.66) for CRP, 0.50 (0.36-0.71) for the total WBC count, and 0.75 (0.58-0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. CONCLUSION: Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.
OBJECTIVE: To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. METHODS: Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3-26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. RESULTS: The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38-0.66) for CRP, 0.50 (0.36-0.71) for the total WBC count, and 0.75 (0.58-0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. CONCLUSION: Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.
Authors: Thomas A Pearson; George A Mensah; R Wayne Alexander; Jeffrey L Anderson; Richard O Cannon; Michael Criqui; Yazid Y Fadl; Stephen P Fortmann; Yuling Hong; Gary L Myers; Nader Rifai; Sidney C Smith; Kathryn Taubert; Russell P Tracy; Frank Vinicor Journal: Circulation Date: 2003-01-28 Impact factor: 29.690
Authors: A Trichopoulou; A Kouris-Blazos; M L Wahlqvist; C Gnardellis; P Lagiou; E Polychronopoulos; T Vassilakou; L Lipworth; D Trichopoulos Journal: BMJ Date: 1995-12-02
Authors: Kristin J Marks; Terryl J Hartman; Suzanne E Judd; Titilayo O Ilori; Katharine L Cheung; David G Warnock; Orlando M Gutiérrez; Michael Goodman; Mary Cushman; William M McClellan Journal: Nephron Extra Date: 2018-08-21