| Literature DB >> 26343779 |
Xingjian Wen1,2,3, Anchun Cheng1,2,3,4, Mingshu Wang1,2,3, Renyong Jia1,2,3, Dekang Zhu2,3, Shun Chen1,2,3, Mafeng Liu1,2,3, Kunfeng Sun1,2,3, Qiao Yang1,2,3, Ying Wu1,2,3, Xiaoyue Chen2,3.
Abstract
Enteroviruses are a large group of small nonenveloped viruses that cause common and debilitating illnesses affecting humans and animals worldwide. The capsid composed by viral structural proteins packs the RNA genome. It is becoming apparent that structural proteins of enteroviruses play versatile roles in the virus-host interaction in the viral life cycle, more than just a shell. Furthermore, structural proteins to some extent may be associated with viral virulence and pathogenesis. Better understanding the roles of structural proteins in enterovirus infection may lead to the development of potential antiviral strategies. Here, we discuss recent advances from studies on the role of structural proteins in enterovirus infection and antiviral therapeutics targeted structural proteins.Entities:
Keywords: P1 proteins; antiviral strategies; enteroviruses; host cellular factors; nonstructural functions; structural proteins; virus–host interaction
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Year: 2015 PMID： 26343779 DOI： 10.2217/fmb.15.62
Source DB: PubMed Journal: Future Microbiol ISSN： 1746-0913 Impact factor: 3.165