Fouad J Moawad1, Evan S Dellon2, Sami R Achem3, Tony Ljuldjuraj4, Daniel J Green2, Corinne L Maydonovitch5, Diana R Brizuela3, Sandeep K Gupta4, Mirna Chehade6. 1. Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, Maryland. Electronic address: Fouad.Moawad@us.army.mil. 2. Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina. 3. Department of Gastroenterology, Mayo Clinic, Jacksonville, Florida. 4. Division of Gastroenterology, Indiana University, Bloomington, Indiana. 5. Gastroenterology Service, Walter Reed National Military Medical Center, Bethesda, Maryland. 6. Departments of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Abstract
BACKGROUND & AIMS: Clinical and endoscopic features of eosinophilic esophagitis (EoE) differ between children and adults and among racial backgrounds. We investigated whether there were any associations between race or sex and clinical presentation, endoscopic features, and histologic findings from patients with EoE of various racial backgrounds. METHODS: We performed a retrospective, multicenter, cross-sectional analysis of 793 patients with EoE (476 adults and 317 children; mean age, 26 years; range, 0.1-84 years; 72% male) from clinical registries at 5 tertiary care centers in the United States. EoE was defined per consensus guidelines. Data with predetermined variables were extracted from clinical registries at each participating institution. RESULTS: Of the study cohort, 660 patients were white (83%), 77 were African American (10%), and 56 were of other races (7%). A significantly larger proportion of white persons than African Americans or other races had dysphagia (74%, 56%, and 53%, respectively; P < .001), food impaction (35%, 13%, and 13%, respectively; P < .001), and features of EoE that included rings (46%, 25%, and 18%, respectively; P < .001) or furrows (70%, 58%, and 55%, respectively; P = .012). Males and females had similar clinical presentations, histories of atopy, findings from endoscopy, and histologic characteristics. A higher proportion of males than females had strictures (17% vs 11%; P = .038). CONCLUSIONS: Race, and to a smaller degree sex, are associated with features of EoE. African Americans have different clinical symptoms and fewer endoscopic features of EoE than white persons. EoE should be considered in African Americans even without typical findings.
BACKGROUND & AIMS: Clinical and endoscopic features of eosinophilic esophagitis (EoE) differ between children and adults and among racial backgrounds. We investigated whether there were any associations between race or sex and clinical presentation, endoscopic features, and histologic findings from patients with EoE of various racial backgrounds. METHODS: We performed a retrospective, multicenter, cross-sectional analysis of 793 patients with EoE (476 adults and 317 children; mean age, 26 years; range, 0.1-84 years; 72% male) from clinical registries at 5 tertiary care centers in the United States. EoE was defined per consensus guidelines. Data with predetermined variables were extracted from clinical registries at each participating institution. RESULTS: Of the study cohort, 660 patients were white (83%), 77 were African American (10%), and 56 were of other races (7%). A significantly larger proportion of white persons than African Americans or other races had dysphagia (74%, 56%, and 53%, respectively; P < .001), food impaction (35%, 13%, and 13%, respectively; P < .001), and features of EoE that included rings (46%, 25%, and 18%, respectively; P < .001) or furrows (70%, 58%, and 55%, respectively; P = .012). Males and females had similar clinical presentations, histories of atopy, findings from endoscopy, and histologic characteristics. A higher proportion of males than females had strictures (17% vs 11%; P = .038). CONCLUSIONS: Race, and to a smaller degree sex, are associated with features of EoE. African Americans have different clinical symptoms and fewer endoscopic features of EoE than white persons. EoE should be considered in African Americans even without typical findings.
Authors: Thomas Greuter; Christian Bussmann; Ekaterina Safroneeva; Alain M Schoepfer; Luc Biedermann; Stephan R Vavricka; Alex Straumann Journal: Am J Gastroenterol Date: 2017-07-18 Impact factor: 10.864
Authors: Justin C Wheeler; Simone Vanoni; Chang Zeng; Lisa Waggoner; Yanfen Yang; David Wu; Jazib Uddin; Rebekah Karns; Leah Kottyan; Vincent Mukkada; Marc E Rothenberg; Simon P Hogan Journal: J Allergy Clin Immunol Date: 2018-12-20 Impact factor: 10.793
Authors: Jonathan M Spergel; Seema S Aceves; Kara Kliewer; Nirmala Gonsalves; Mirna Chehade; Joshua B Wechsler; Marion Groetch; Joshua Friedlander; Evan S Dellon; Wendy Book; Ikuo Hirano; Amanda B Muir; Antonella Cianferoni; Lisa Spencer; Chris A Liacouras; Edaire Cheng; Leah Kottyan; Ting Wen; Thomas Platts-Mills; Marc E Rothenberg Journal: J Allergy Clin Immunol Date: 2018-05-24 Impact factor: 10.793
Authors: Mirna Chehade; Stacie M Jones; Robbie D Pesek; A Wesley Burks; Brian P Vickery; Robert A Wood; Donald Y M Leung; Glenn T Furuta; David M Fleischer; Alice K Henning; Peter Dawson; Robert W Lindblad; Scott H Sicherer; J Pablo Abonia; Joseph D Sherrill; Hugh A Sampson; Marc E Rothenberg Journal: J Allergy Clin Immunol Pract Date: 2018-08-01
Authors: Dustin Albert; Theresa A Heifert; Steve B Min; Corinne L Maydonovitch; Thomas P Baker; Yen-Ju Chen; Fouad J Moawad Journal: Dig Dis Sci Date: 2016-04-19 Impact factor: 3.199