Brittney S Lange-Maia1, Anne B Newman1, Jane A Cauley1, Robert M Boudreau1, John M Jakicic2, Paolo Caserotti3, Nancy W Glynn1, Tamara B Harris4, Stephen B Kritchevsky5, Ann V Schwartz6, Suzanne Satterfield7, Eleanor M Simonsick8, Aaron I Vinik9, Sasa Zivkovic10, Elsa S Strotmeyer11. 1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. 2. Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, PA. 3. Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. 4. Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD. 5. Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC. 6. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA. 7. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN. 8. Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD. 9. Department of Neurobiology, Eastern Virginia Medical School, Norfolk, VA. 10. Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA. 11. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Electronic address: StrotmeyerE@edc.pitt.edu.
Abstract
OBJECTIVES: To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. DESIGN: Prospective cohort study with 6 years of follow-up. SETTING: Two university research clinics. PARTICIPANTS: Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age ± SD, 76.5±2.9y; 48.2% men; 38.2% black) and a subset with longitudinal data (n=1178). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400 m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. RESULTS: In separate, fully adjusted linear mixed models, poor vibration threshold (>130 μm), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0 s, 14.4s, and 6.9 s slower, respectively; P<.05 for each). Poor motor amplitude (<1 mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. CONCLUSIONS: Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance-a critical component for remaining independent in the community.
OBJECTIVES: To determine whether lower extremity sensorimotor peripheral nerve deficits are associated with reduced walking endurance in older adults. DESIGN: Prospective cohort study with 6 years of follow-up. SETTING: Two university research clinics. PARTICIPANTS: Community-dwelling older adults enrolled in the Health, Aging and Body Composition Study from the 2000-2001 annual clinical examination (N=2393; mean age ± SD, 76.5±2.9y; 48.2% men; 38.2% black) and a subset with longitudinal data (n=1178). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Participants underwent peripheral nerve function examination in 2000-2001, including peroneal motor nerve conduction amplitude and velocity, vibration perception threshold, and monofilament testing. Symptoms of lower extremity peripheral neuropathy included numbness or tingling and sudden stabbing, burning, pain, or aches in the feet or legs. The Long Distance Corridor Walk (LDCW) (400 m) was administered in 2000-2001 and every 2 years afterward for 6 years to assess endurance walking performance over time. RESULTS: In separate, fully adjusted linear mixed models, poor vibration threshold (>130 μm), 10-g and 1.4-g monofilament insensitivity were each associated with a slower 400-m walk completion time (16.0 s, 14.4s, and 6.9 s slower, respectively; P<.05 for each). Poor motor amplitude (<1 mV), poor vibration perception threshold, and 10-g monofilament insensitivity were related to greater slowing per year (4.7, 4.2, and 3.8 additional seconds per year, respectively; P<.05), although poor motor amplitude was not associated with initial completion time. CONCLUSIONS: Poorer sensorimotor peripheral nerve function is related to slower endurance walking and greater slowing longitudinally. Interventions to reduce the burden of sensorimotor peripheral nerve function impairments should be considered to help older adults maintain walking endurance-a critical component for remaining independent in the community.
Authors: H E Resnick; A I Vinik; A V Schwartz; S G Leveille; F L Brancati; J Balfour; J M Guralnik Journal: Diabetes Care Date: 2000-11 Impact factor: 19.112
Authors: Marco Pahor; Jack M Guralnik; Walter T Ambrosius; Steven Blair; Denise E Bonds; Timothy S Church; Mark A Espeland; Roger A Fielding; Thomas M Gill; Erik J Groessl; Abby C King; Stephen B Kritchevsky; Todd M Manini; Mary M McDermott; Michael E Miller; Anne B Newman; W Jack Rejeski; Kaycee M Sink; Jeff D Williamson Journal: JAMA Date: 2014-06-18 Impact factor: 56.272
Authors: E M Simonsick; A B Newman; M C Nevitt; S B Kritchevsky; L Ferrucci; J M Guralnik; T Harris Journal: J Gerontol A Biol Sci Med Sci Date: 2001-10 Impact factor: 6.053
Authors: Rachel E Ward; Robert M Boudreau; Paolo Caserotti; Tamara B Harris; Sasa Zivkovic; Bret H Goodpaster; Suzanne Satterfield; Stephen Kritchevsky; Ann V Schwartz; Aaron I Vinik; Jane A Cauley; Anne B Newman; Elsa S Strotmeyer Journal: J Gerontol A Biol Sci Med Sci Date: 2014-10-15 Impact factor: 6.053
Authors: Mary McGrae McDermott; Jack M Guralnik; Monique Albay; Stefania Bandinelli; Benedetta Miniati; Luigi Ferrucci Journal: J Am Geriatr Soc Date: 2004-03 Impact factor: 5.562
Authors: Brittney S Lange-Maia; Anne B Newman; John M Jakicic; Jane A Cauley; Robert M Boudreau; Ann V Schwartz; Eleanor M Simonsick; Suzanne Satterfield; Aaron I Vinik; Sasa Zivkovic; Tamara B Harris; Elsa S Strotmeyer Journal: Exp Gerontol Date: 2017-04-22 Impact factor: 4.032
Authors: Ranjani N Moorthi; Simit Doshi; Linda F Fried; Sharon M Moe; Mark J Sarnak; Suzanne Satterfield; Ann V Schwartz; Michael Shlipak; Brittney S Lange-Maia; Tamara B Harris; Anne B Newman; Elsa S Strotmeyer Journal: Nephrol Dial Transplant Date: 2019-04-01 Impact factor: 5.992
Authors: Rafaela Soares Rech; Elsa S Strotmeyer; Brittney S Lange-Maia; Fernando Neves Hugo; Bárbara Niegia Garcia de Goulart; Juliana Balbinot Hilgert; Eleanor M Simonsick Journal: Aging Clin Exp Res Date: 2020-04-10 Impact factor: 3.636
Authors: Simit Doshi; Ranjani N Moorthi; Linda F Fried; Mark J Sarnak; Suzanne Satterfield; Michael Shlipak; Brittney S Lange-Maia; Anne B Newman; Elsa S Strotmeyer Journal: PLoS One Date: 2020-12-15 Impact factor: 3.240
Authors: Kristen R Weaver; Mari A Griffioen; N Jennifer Klinedinst; Elizabeth Galik; Ana C Duarte; Luana Colloca; Barbara Resnick; Susan G Dorsey; Cynthia L Renn Journal: Front Pain Res (Lausanne) Date: 2022-01-28
Authors: Luigi Ferrucci; Rachel Cooper; Michelle Shardell; Eleanor M Simonsick; Jennifer A Schrack; Diana Kuh Journal: J Gerontol A Biol Sci Med Sci Date: 2016-03-14 Impact factor: 6.053
Authors: Kelly R Ylitalo; Elsa S Strotmeyer; Kelley Pettee Gabriel; Brittney S Lange-Maia; Nancy E Avis; Carrie A Karvonen-Gutierrez Journal: J Gerontol A Biol Sci Med Sci Date: 2020-09-25 Impact factor: 6.053