Rachel E Ward1, Robert M Boudreau1, Paolo Caserotti2, Tamara B Harris3, Sasa Zivkovic4, Bret H Goodpaster5, Suzanne Satterfield6, Stephen Kritchevsky7, Ann V Schwartz8, Aaron I Vinik9, Jane A Cauley1, Anne B Newman1, Elsa S Strotmeyer10. 1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania. 2. Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. 3. Laboratory of Epidemiology, Biometry, and Demography, National Institute on Aging, NIH, Bethesda, Maryland. 4. VA Pittsburgh HCS and Department of Neurology and. 5. Department of Medicine, School of Medicine, University of Pittsburgh, Pennsylvania. 6. Department of Preventive Medicine, University of Tennessee, Health Science Center, Memphis. 7. Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina. 8. Department of Epidemiology and Biostatistics, University of California, San Francisco. 9. Department of Neurobiology, Eastern Virginia Medical School, Norfolk. 10. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania. StrotmeyerE@edc.pitt.edu.
Abstract
BACKGROUND: Poor peripheral nerve function is common in older adults and may be a risk factor for strength decline, although this has not been assessed longitudinally. METHODS: We assessed whether sensorimotor peripheral nerve function predicts strength longitudinally in 1,830 participants (age = 76.3 ± 2.8, body mass index = 27.2 ± 4.6kg/m(2), strength = 96.3 ± 34.7 Nm, 51.0% female, 34.8% black) from the Health ABC study. Isokinetic quadriceps strength was measured semiannually over 6 years. Peroneal motor nerve conduction amplitude and velocity were recorded. Sensory nerve function was assessed with 10-g and 1.4-g monofilaments and average vibration detection threshold at the toe. Lower-extremity neuropathy symptoms were self-reported. RESULTS: Worse vibration detection threshold predicted 2.4% lower strength in men and worse motor amplitude and two symptoms predicted 2.5% and 8.1% lower strength, respectively, in women. Initial 10-g monofilament insensitivity predicted 14.2% lower strength and faster strength decline in women and 6.6% lower strength in men (all p < .05). CONCLUSION: Poor nerve function predicted lower strength and faster strength decline. Future work should examine interventions aimed at preventing declines in strength in older adults with impaired nerve function.
BACKGROUND: Poor peripheral nerve function is common in older adults and may be a risk factor for strength decline, although this has not been assessed longitudinally. METHODS: We assessed whether sensorimotor peripheral nerve function predicts strength longitudinally in 1,830 participants (age = 76.3 ± 2.8, body mass index = 27.2 ± 4.6kg/m(2), strength = 96.3 ± 34.7 Nm, 51.0% female, 34.8% black) from the Health ABC study. Isokinetic quadriceps strength was measured semiannually over 6 years. Peroneal motor nerve conduction amplitude and velocity were recorded. Sensory nerve function was assessed with 10-g and 1.4-g monofilaments and average vibration detection threshold at the toe. Lower-extremity neuropathy symptoms were self-reported. RESULTS: Worse vibration detection threshold predicted 2.4% lower strength in men and worse motor amplitude and two symptoms predicted 2.5% and 8.1% lower strength, respectively, in women. Initial 10-g monofilament insensitivity predicted 14.2% lower strength and faster strength decline in women and 6.6% lower strength in men (all p < .05). CONCLUSION: Poor nerve function predicted lower strength and faster strength decline. Future work should examine interventions aimed at preventing declines in strength in older adults with impaired nerve function.
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