| Literature DB >> 26342547 |
Manuela G Neuman1, Stephen Malnick2, Yaakov Maor2, Radu M Nanau3, Ehud Melzer2, Peter Ferenci4, Helmut K Seitz5, Sebastian Mueller5, Haim Mell6, Didier Samuel7, Lawrence B Cohen8, Kusum K Kharbanda9, Natalia A Osna9, Murali Ganesan9, Kyle J Thompson10, Iain H McKillop10, Abraham Bautista11, Ramon Bataller12, Samuel W French13.
Abstract
The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a legally commercialized and taxable product. Drinking alcohol, particularly from a young age, is a major health problem. Alcoholism is known to contribute to morbidity and mortality. A systematic literature search was performed in order to obtain updated data (2008-2015). The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD. Alcohol-mediated hepatocarcinogenesis is also discussed in the presence or absence of co-morbidities such as viral hepatitis C as well as therapeutic the role of innate immunity in ALD-HCV. Moreover, emphasis was placed on alcohol and drug interactions, as well as liver transplantation for end-stage ALD. Finally, the time came to eradicate alcohol-induced liver and intestinal damage by using betaine.Entities:
Keywords: Alcohol dehydrogenase; Alcoholic liver disease; Betaine; CYP2E1; Hepatitis B and C viral infection; Hepatocarcinogenesis; Human immunodeficiency virus; Liver fibrosis; Liver transplant
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Year: 2015 PMID： 26342547 DOI： 10.1016/j.yexmp.2015.09.001
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 3.362