Literature DB >> 33921359

Non-Alcoholic Fatty Liver Disease and Cardiovascular Comorbidities: Pathophysiological Links, Diagnosis, and Therapeutic Management.

Alexandra Jichitu1, Simona Bungau2, Ana Maria Alexandra Stanescu3, Cosmin Mihai Vesa4, Mirela Marioara Toma2, Cristiana Bustea4, Stela Iurciuc5, Marius Rus6, Nicolae Bacalbasa7,8, Camelia Cristina Diaconu1,3.   

Abstract

Non-alcoholic fatty liver disease (NAFLD) has a growing prevalence in recent years. Its association with cardiovascular disease has been intensively studied, and certain correlations have been identified. The connection between these two entities has lately aroused interest regarding therapeutic management. In order to find the best therapeutic options, a detailed understanding of the pathophysiology that links (NAFLD) to cardiovascular comorbidities is needed. This review focuses on the pathogenic mechanisms that are behind these two diseases and on the therapeutic management available at this time.

Entities:  

Keywords:  cardiovascular comorbidities; non-alcoholic fatty liver disease; pathophysiology; treatment

Year:  2021        PMID： 33921359      PMCID： PMC8069361          DOI： 10.3390/diagnostics11040689

Source DB:  PubMed          Journal:  Diagnostics (Basel)        ISSN： 2075-4418


  212 in total

1.  Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus.

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Journal:  Am J Cardiol       Date:  2001-11-15       Impact factor: 2.778

2.  Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis: A Meta-analysis.

Authors:  Giovanni Musso; Maurizio Cassader; Elena Paschetta; Roberto Gambino
Journal:  JAMA Intern Med       Date:  2017-05-01       Impact factor: 21.873

3.  Ectopic fat depots and left ventricular function in nondiabetic men with nonalcoholic fatty liver disease.

Authors:  Marit Granér; Kristofer Nyman; Reijo Siren; Markku O Pentikäinen; Jesper Lundbom; Antti Hakkarainen; Kirsi Lauerma; Nina Lundbom; Markku S Nieminen; Marja-Riitta Taskinen
Journal:  Circ Cardiovasc Imaging       Date:  2014-12-30       Impact factor: 7.792

Review 4.  The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance.

Authors:  Matthew J Watt; Paula M Miotto; William De Nardo; Magdalene K Montgomery
Journal:  Endocr Rev       Date:  2019-10-01       Impact factor: 19.871

5.  Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2.

Authors:  John Willy Haukeland; Jan Kristian Damås; Zbigniew Konopski; Else Marit Løberg; Terese Haaland; Ingeborg Goverud; Peter A Torjesen; Kåre Birkeland; Kristian Bjøro; Pål Aukrust
Journal:  J Hepatol       Date:  2006-03-20       Impact factor: 25.083

6.  Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Authors:  Umut Ozcan; Qiong Cao; Erkan Yilmaz; Ann-Hwee Lee; Neal N Iwakoshi; Esra Ozdelen; Gürol Tuncman; Cem Görgün; Laurie H Glimcher; Gökhan S Hotamisligil
Journal:  Science       Date:  2004-10-15       Impact factor: 47.728

7.  Association between nonalcoholic fatty liver disease and cardiovascular risk in obese children and adolescents.

Authors:  Hayrullah Alp; Sevim Karaarslan; Beray Selver Eklioğlu; Mehmet Emre Atabek; Hakan Altın; Tamer Baysal
Journal:  Can J Cardiol       Date:  2012-10-02       Impact factor: 5.223

8.  Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis.

Authors:  Eugen Florin Georgescu; Reanina Ionescu; Mihaela Niculescu; Laurentiu Mogoanta; Liliana Vancica
Journal:  World J Gastroenterol       Date:  2009-02-28       Impact factor: 5.742

9.  Insulin-mediated glucose metabolism in the relationship between dietary intake and sympathetic nervous system activity.

Authors:  L Landsberg; J B Young
Journal:  Int J Obes       Date:  1985

Review 10.  Inflammation in atrial fibrillation.

Authors:  Yutao Guo; Gregory Y H Lip; Stavros Apostolakis
Journal:  J Am Coll Cardiol       Date:  2012-12-04       Impact factor: 24.094
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  4 in total

1.  Relationship between non-invasively detected liver fibrosis and in-hospital outcomes in patients with acute coronary syndrome undergoing PCI.

Authors:  Flavio Giuseppe Biccirè; Francesco Barillà; Emanuele Sammartini; Edoardo Maria Dacierno; Gaetano Tanzilli; Daniele Pastori
Journal:  Clin Res Cardiol       Date:  2022-08-11       Impact factor: 6.138

2.  Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH.

Authors:  David Montefusco; Maryam Jamil; Melissa A Maczis; William Schroeder; Moshe Levi; Suman Ranjit; Jeremy Allegood; Dipankar Bandyopadhyay; Reuben Retnam; Sarah Spiegel; L Ashley Cowart
Journal:  Mol Metab       Date:  2022-06-06       Impact factor: 8.568

3.  Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial.

Authors:  Hamed Kord Varkaneh; Ammar Salehi Sahlabadi; Mihnea-Alexandru Găman; Mohsen Rajabnia; Melahat Sedanur Macit-Çelebi; Heitor O Santos; Azita Hekmatdoost
Journal:  Front Nutr       Date:  2022-07-26

4.  Establishment and evaluation of a risk-prediction model for hypertension in elderly patients with NAFLD from a health management perspective.

Authors:  An Zhang; Xin Luo; Hong Pan; Xinxin Shen; Baocheng Liu; Dong Li; Jijia Sun
Journal:  Sci Rep       Date:  2022-09-07       Impact factor: 4.996
  4 in total

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