Matheus H L Arts1, Rose M Collard2, Hannie C Comijs3, Marij Zuidersma4, Sophia E de Rooij5, Paul Naarding6, Richard C Oude Voshaar7. 1. Mental Health Center Friesland, Department of Old Age Psychiatry, Leeuwarden, The Netherlands; University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands. Electronic address: Matheus.Arts@ggzfriesland.nl. 2. Radboud University Medical Center, Department of Psychiatry, Nijmegen, The Netherlands. 3. VU University Medical Center/GGZinGeest, EMGO Institute for Health and Care Research, Department of Psychiatry, Amsterdam, The Netherlands. 4. University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands. 5. University of Groningen, University Medical Center Groningen, Department of Geriatric Medicine, Groningen, The Netherlands. 6. Radboud University Medical Center, Department of Psychiatry, Nijmegen, The Netherlands; GGNet, Department of Old Age Psychiatry, Apeldoorn, The Netherlands. 7. University of Groningen, University Medical Center Groningen, University Center for Psychiatry, Groningen, The Netherlands; Radboud University Medical Center, Department of Psychiatry, Nijmegen, The Netherlands.
Abstract
OBJECTIVES: Cognitive frailty has recently been defined as the co-occurrence of physical frailty and cognitive impairment. Late-life depression is associated with both physical frailty and cognitive impairment, especially processing speed and executive functioning. The objective of this study was to investigate the association between physical frailty and cognitive functioning in depressed older persons. DESIGN: Baseline data of a depressed cohort, participating in the Netherlands Study of Depression in Older persons (NESDO). SETTING: Primary care and specialized mental health care. PARTICIPANTS: A total of 378 patients (≥60 years) with depression according to DSM-IV criteria and a MMSE score of 24 points or higher. MEASUREMENTS: The physical frailty phenotype as well as its individual criteria (weight loss, weakness, exhaustion, slowness, low activity). Cognitive functioning was examined in 4 domains: verbal memory, working memory, interference control, and processing speed. RESULTS: Of the 378 depressed patients (range 60-90 years; 66.1% women), 61 were classified as robust (no frailty criteria present), 214 as prefrail (1 or 2 frailty criteria present), and 103 as frail (≥3 criteria). Linear regression analyses, adjusted for confounders, showed that the severity of physical frailty was associated with poorer verbal memory (ß = -0.13, P = .039), slower processing speed (ß = -0.20, P = .001), and decreased working memory (ß = -0.18, P = .004), but not with changes in interference control (ß = 0.04, P = .54). CONCLUSION: In late-life depression, physical frailty is associated with poorer cognitive functioning, although not consistently for executive functioning. Future studies should examine whether cognitive impairment in the presence of physical frailty belongs to cognitive frailty and is indeed an important concept to identify a specific subgroup of depressed older patients, who need multimodal treatment strategies integrating physical, cognitive, and psychological functioning.
OBJECTIVES: Cognitive frailty has recently been defined as the co-occurrence of physical frailty and cognitive impairment. Late-life depression is associated with both physical frailty and cognitive impairment, especially processing speed and executive functioning. The objective of this study was to investigate the association between physical frailty and cognitive functioning in depressed older persons. DESIGN: Baseline data of a depressed cohort, participating in the Netherlands Study of Depression in Older persons (NESDO). SETTING: Primary care and specialized mental health care. PARTICIPANTS: A total of 378 patients (≥60 years) with depression according to DSM-IV criteria and a MMSE score of 24 points or higher. MEASUREMENTS: The physical frailty phenotype as well as its individual criteria (weight loss, weakness, exhaustion, slowness, low activity). Cognitive functioning was examined in 4 domains: verbal memory, working memory, interference control, and processing speed. RESULTS: Of the 378 depressedpatients (range 60-90 years; 66.1% women), 61 were classified as robust (no frailty criteria present), 214 as prefrail (1 or 2 frailty criteria present), and 103 as frail (≥3 criteria). Linear regression analyses, adjusted for confounders, showed that the severity of physical frailty was associated with poorer verbal memory (ß = -0.13, P = .039), slower processing speed (ß = -0.20, P = .001), and decreased working memory (ß = -0.18, P = .004), but not with changes in interference control (ß = 0.04, P = .54). CONCLUSION: In late-life depression, physical frailty is associated with poorer cognitive functioning, although not consistently for executive functioning. Future studies should examine whether cognitive impairment in the presence of physical frailty belongs to cognitive frailty and is indeed an important concept to identify a specific subgroup of depressed older patients, who need multimodal treatment strategies integrating physical, cognitive, and psychological functioning.
Authors: Keith A Shaughnessy; Kyle J Hackney; Brian C Clark; William J Kraemer; Donna J Terbizan; Ryan R Bailey; Ryan McGrath Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: M K Borges; C V Romanini; N A Lima; M Petrella; D L da Costa; V N An; B N Aguirre; J R Galdeano; I C Fernandes; J F Cecato; E C Robello; R C Oude Voshaar; I Aprahamian Journal: J Nutr Health Aging Date: 2021 Impact factor: 4.075