| Literature DB >> 26339458 |
Li-Quan Dong1, Li-Li Yan2, Xu-Dong Pan1, Jin-Hua Hu3, Jun-Wei Zhang4.
Abstract
The effect of neovibsanin scaffold (NS) on the spatial cognitive functions of rats with lobal cerebrovascular hypoperfusion was investigated. Rats were divided into long-term memory (LTM) and short-term memory (STM) groups with 15 rats in each group. The groups were subdivided into 3 groups: control group comprised of 5 rats without surgery, untreated group of 5 rats left without treatment after 2OV, and NS treatment group with 5 rats receiving 5 mg/kg daily for 12 weeks of 2VO operation. NS-treatment caused a marked decrease in the escape latency time and total distance travelled in the treatment group compared to untreated group which was evident from the working memory test. The animals of treatment group also showed significant improvement over that of untreated group in maze test performance. Furthermore, NS treatment also resulted in significant improvement in the probe memory test performance in treatment group compared to untreated group. These findings suggest that NS exhibits therapeutic effect on the spatial cognitive preservation in rats with chronic epilepsy.Entities:
Keywords: Chronic epilepsy; Morris water maze; cognitive; escape latency; working memory test
Mesh：
Substances：
Year: 2015 PMID： 26339458 PMCID： PMC4555786
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625