Juan I González-Montalvo1,2,3, Teresa Alarcón1,2,3, Pilar Gotor1,3, Rocío Queipo4,3, Rocío Velasco1, Rubén Hoyos1, Armando Pardo1, Angel Otero4,3. 1. Geriatrics Department, La Paz University Hospital, Madrid, Spain. 2. Medicine Department, Autonoma University of Madrid, Madrid, Spain. 3. La Paz University Hospital Research Institute, IdiPAZ, Madrid, Spain. 4. Preventive Medicine Department, Autonoma University of Madrid, Madrid, Spain.
Abstract
AIM: Current international criteria provide standardized procedures to diagnose sarcopenia in older people. However, to date few data exist on patients with acute disease. The present study was carried out to determine the frequency of sarcopenia in acute hip fracture patients, and its association with their baseline characteristics and prognosis during hospitalization. METHODS: Data were collected from 509 consecutive patients hospitalized for hip fracture. The European Working Group on Sarcopenia in Older People Criteria for sarcopenia were applied in the first 72 h. Muscle mass was measured by electrical bioimpedance and grip strength by hydraulic dynamometer. Clinical, functional and cognitive characteristics were assessed at baseline and hospital discharge, and their association with the presence of sarcopenia was studied. RESULTS: A total of 479 patients (94%) met the inclusion criteria. The mean age was 85.3 (SD 6.8 years). The frequency of sarcopenia was 17.1% (12.4% in men, 18.3% in women). Sarcopenia was associated with residence in nursing homes (30.5% vs 19.6%, P = 0.030), older age (86.8, SD 6.2 vs 85.1, SD 6.9 years, P = 0.038), and lower body mass index (23.1, SD 3.6 vs 25.6, SD 4.23, P < 0.001). In the multivariate analysis, only low body mass index was predictive of sarcopenia (OR 0.85, 95% CI 0.80-0.91). Sarcopenia was associated with worse functional prognosis at discharge in the crude analysis (OR 1.88, 95% CI 1.15-3.07), but not in the multivariate analysis (OR 1.68, 95% CI 0.99-2.84). CONCLUSIONS: Sarcopenia was detected in almost one of five acute hip fracture patients and was associated with lower body mass index, but an association with worse prognosis at discharge could not be confirmed. Geriatr Gerontol Int 2016; 16: 1021-1027.
AIM: Current international criteria provide standardized procedures to diagnose sarcopenia in older people. However, to date few data exist on patients with acute disease. The present study was carried out to determine the frequency of sarcopenia in acute hip fracturepatients, and its association with their baseline characteristics and prognosis during hospitalization. METHODS: Data were collected from 509 consecutive patients hospitalized for hip fracture. The European Working Group on Sarcopenia in Older People Criteria for sarcopenia were applied in the first 72 h. Muscle mass was measured by electrical bioimpedance and grip strength by hydraulic dynamometer. Clinical, functional and cognitive characteristics were assessed at baseline and hospital discharge, and their association with the presence of sarcopenia was studied. RESULTS: A total of 479 patients (94%) met the inclusion criteria. The mean age was 85.3 (SD 6.8 years). The frequency of sarcopenia was 17.1% (12.4% in men, 18.3% in women). Sarcopenia was associated with residence in nursing homes (30.5% vs 19.6%, P = 0.030), older age (86.8, SD 6.2 vs 85.1, SD 6.9 years, P = 0.038), and lower body mass index (23.1, SD 3.6 vs 25.6, SD 4.23, P < 0.001). In the multivariate analysis, only low body mass index was predictive of sarcopenia (OR 0.85, 95% CI 0.80-0.91). Sarcopenia was associated with worse functional prognosis at discharge in the crude analysis (OR 1.88, 95% CI 1.15-3.07), but not in the multivariate analysis (OR 1.68, 95% CI 0.99-2.84). CONCLUSIONS:Sarcopenia was detected in almost one of five acute hip fracturepatients and was associated with lower body mass index, but an association with worse prognosis at discharge could not be confirmed. Geriatr Gerontol Int 2016; 16: 1021-1027.
Authors: Robert D Boutin; Sara Bamrungchart; Cyrus P Bateni; Daniel P Beavers; Kristen M Beavers; John P Meehan; Leon Lenchik Journal: AJR Am J Roentgenol Date: 2017-03-07 Impact factor: 3.959
Authors: M Díaz de Bustamante; T Alarcón; R Menéndez-Colino; R Ramírez-Martín; Á Otero; J I González-Montalvo Journal: Eur J Clin Nutr Date: 2017-05-17 Impact factor: 4.016
Authors: Denise L Orwig; Jay Magaziner; Roger A Fielding; Hao Zhu; Ellen F Binder; Peggy M Cawthon; Shalender Bhasin; Rosaly Correa-de-Araujo; Todd Manini; Sheena Patel; Michelle Shardell; Thomas G Travison Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053