Literature DB >> 26337695

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.

Laura J Rasmussen-Torvik1, Abigail S Baldridge2, Jennifer A Pacheco3, Sharon A Aufox3, Kwang-Youn A Kim2, Jonathan C Silverstein4, Erwin W Denham4, Eric Hungness5, Maureen E Smith3, Philip Greenland2.   

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

Entities:  

Keywords:  Bariatric surgery; Long-term weight loss; Obesity GWAS; Predictors; Repeated measures; Roux-en-Y gastric bypass; SNP

Mesh：

Substances：

Year:  2015        PMID： 26337695      PMCID： PMC4598314          DOI： 10.1007/s11695-015-1872-7

Source DB:  PubMed          Journal:  Obes Surg        ISSN： 0960-8923            Impact factor:   4.129


  11 in total

1.  Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases.

Authors:  M A Sarzynski; P Jacobson; T Rankinen; B Carlsson; L Sjöström; C Bouchard; L M S Carlsson
Journal:  Int J Obes (Lond)       Date:  2010-08-24       Impact factor: 5.095

2.  High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery.

Authors:  Christopher D Still; G Craig Wood; Xin Chu; Robert Erdman; Christina H Manney; Peter N Benotti; Anthony T Petrick; William E Strodel; Uyenlinh L Mirshahi; Tooraj Mirshahi; David J Carey; Glenn S Gerhard
Journal:  Obesity (Silver Spring)       Date:  2011-02-10       Impact factor: 5.002

3.  The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery.

Authors:  Uyenlinh L Mirshahi; Christopher D Still; Kathryn K Masker; Glenn S Gerhard; David J Carey; Tooraj Mirshahi
Journal:  J Clin Endocrinol Metab       Date:  2011-10-05       Impact factor: 5.958

4.  Genetic risk score does not predict the outcome of obesity surgery.

Authors:  P Käkelä; T Jääskeläinen; J Torpström; I Ilves; S Venesmaa; M Pääkkönen; H Gylling; H Paajanen; M Uusitupa; J Pihlajamäki
Journal:  Obes Surg       Date:  2014-01       Impact factor: 4.129

5.  Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.

Authors:  Erica S Rinella; Christopher Still; Yongzhao Shao; G Craig Wood; Xin Chu; Brenda Salerno; Glenn S Gerhard; Harry Ostrer
Journal:  J Clin Endocrinol Metab       Date:  2013-04-30       Impact factor: 5.958

6.  Weight loss after gastric bypass is associated with a variant at 15q26.1.

Authors:  Ida J Hatoum; Danielle M Greenawalt; Chris Cotsapas; Mark J Daly; Marc L Reitman; Lee M Kaplan
Journal:  Am J Hum Genet       Date:  2013-05-02       Impact factor: 11.025

7.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

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Jouke-Jan Hottenga; Asa Johansson; Toby Johnson; Marika Kaakinen; Karen Kapur; Shamika Ketkar; Joshua W Knowles; Peter Kraft; Aldi T Kraja; Claudia Lamina; Michael F Leitzmann; Barbara McKnight; Andrew P Morris; Ken K Ong; John R B Perry; Marjolein J Peters; Ozren Polasek; Inga Prokopenko; Nigel W Rayner; Samuli Ripatti; Fernando Rivadeneira; Neil R Robertson; Serena Sanna; Ulla Sovio; Ida Surakka; Alexander Teumer; Sophie van Wingerden; Veronique Vitart; Jing Hua Zhao; Christine Cavalcanti-Proença; Peter S Chines; Eva Fisher; Jennifer R Kulzer; Cecile Lecoeur; Narisu Narisu; Camilla Sandholt; Laura J Scott; Kaisa Silander; Klaus Stark; Mari-Liis Tammesoo; Tanya M Teslovich; Nicholas John Timpson; Richard M Watanabe; Ryan Welch; Daniel I Chasman; Matthew N Cooper; John-Olov Jansson; Johannes Kettunen; Robert W Lawrence; Niina Pellikka; Markus Perola; Liesbeth Vandenput; Helene Alavere; Peter Almgren; Larry D Atwood; Amanda J Bennett; Reiner Biffar; Lori L Bonnycastle; Stefan R Bornstein; Thomas A Buchanan; Harry Campbell; Ian N M Day; Mariano Dei; Marcus Dörr; Paul Elliott; Michael R Erdos; Johan G Eriksson; Nelson B Freimer; Mao Fu; Stefan Gaget; Eco J C Geus; Anette P Gjesing; Harald Grallert; Jürgen Grässler; Christopher J Groves; Candace Guiducci; Anna-Liisa Hartikainen; Neelam Hassanali; Aki S Havulinna; Karl-Heinz Herzig; Andrew A Hicks; Jennie Hui; Wilmar Igl; Pekka Jousilahti; Antti Jula; Eero Kajantie; Leena Kinnunen; Ivana Kolcic; Seppo Koskinen; Peter Kovacs; Heyo K Kroemer; Vjekoslav Krzelj; Johanna Kuusisto; Kirsti Kvaloy; Jaana Laitinen; Olivier Lantieri; G Mark Lathrop; Marja-Liisa Lokki; Robert N Luben; Barbara Ludwig; Wendy L McArdle; Anne McCarthy; Mario A Morken; Mari Nelis; Matt J Neville; Guillaume Paré; Alex N Parker; John F Peden; Irene Pichler; Kirsi H Pietiläinen; Carl G P Platou; Anneli Pouta; Martin Ridderstråle; Nilesh J Samani; Jouko Saramies; Juha Sinisalo; Jan H Smit; Rona J Strawbridge; Heather M Stringham; Amy J Swift; Maris Teder-Laving; Brian Thomson; Gianluca Usala; Joyce B J van Meurs; Gert-Jan van Ommen; Vincent Vatin; Claudia B Volpato; Henri Wallaschofski; G Bragi Walters; Elisabeth Widen; Sarah H Wild; Gonneke Willemsen; Daniel R Witte; Lina Zgaga; Paavo Zitting; John P Beilby; Alan L James; Mika Kähönen; Terho Lehtimäki; Markku S Nieminen; Claes Ohlsson; Lyle J Palmer; Olli Raitakari; Paul M Ridker; Michael Stumvoll; Anke Tönjes; Jorma Viikari; Beverley Balkau; Yoav Ben-Shlomo; Richard N Bergman; Heiner Boeing; George Davey Smith; Shah Ebrahim; Philippe Froguel; Torben Hansen; Christian Hengstenberg; Kristian Hveem; Bo Isomaa; Torben Jørgensen; Fredrik Karpe; Kay-Tee Khaw; Markku Laakso; Debbie A Lawlor; Michel Marre; Thomas Meitinger; Andres Metspalu; Kristian Midthjell; Oluf Pedersen; Veikko Salomaa; Peter E H Schwarz; Tiinamaija Tuomi; Jaakko Tuomilehto; Timo T Valle; Nicholas J Wareham; Alice M Arnold; Jacques S Beckmann; Sven Bergmann; Eric Boerwinkle; Dorret I Boomsma; Mark J Caulfield; Francis S Collins; Gudny Eiriksdottir; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Andrew T Hattersley; Albert Hofman; Frank B Hu; Thomas Illig; Carlos Iribarren; Marjo-Riitta Jarvelin; W H Linda Kao; Jaakko Kaprio; Lenore J Launer; Patricia B Munroe; Ben Oostra; Brenda W Penninx; Peter P Pramstaller; Bruce M Psaty; Thomas Quertermous; Aila Rissanen; Igor Rudan; Alan R Shuldiner; Nicole Soranzo; Timothy D Spector; Ann-Christine Syvanen; Manuela Uda; André Uitterlinden; Henry Völzke; Peter Vollenweider; James F Wilson; Jacqueline C Witteman; Alan F Wright; Gonçalo R Abecasis; Michael Boehnke; Ingrid B Borecki; Panos Deloukas; Timothy M Frayling; Leif C Groop; Talin Haritunians; David J Hunter; Robert C Kaplan; Kari E North; Jeffrey R O'Connell; Leena Peltonen; David Schlessinger; David P Strachan; Joel N Hirschhorn; Themistocles L Assimes; H-Erich Wichmann; Unnur Thorsteinsdottir; Cornelia M van Duijn; Kari Stefansson; L Adrienne Cupples; Ruth J F Loos; Inês Barroso; Mark I McCarthy; Caroline S Fox; Karen L Mohlke; Cecilia M Lindgren
Journal:  Nat Genet       Date:  2010-10-10       Impact factor: 38.330

8.  Advantages of percent weight loss as a method of reporting weight loss after Roux-en-Y gastric bypass.

Authors:  Ida J Hatoum; Lee M Kaplan
Journal:  Obesity (Silver Spring)       Date:  2013-05-13       Impact factor: 5.002

9.  Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:  Elizabeth K Speliotes; Cristen J Willer; Sonja I Berndt; Keri L Monda; Gudmar Thorleifsson; Anne U Jackson; Hana Lango Allen; Cecilia M Lindgren; Jian'an Luan; Reedik Mägi; Joshua C Randall; Sailaja Vedantam; Thomas W Winkler; Lu Qi; Tsegaselassie Workalemahu; Iris M Heid; Valgerdur Steinthorsdottir; Heather M Stringham; Michael N Weedon; Eleanor Wheeler; Andrew R Wood; Teresa Ferreira; Robert J Weyant; Ayellet V Segrè; Karol Estrada; Liming Liang; James Nemesh; Ju-Hyun Park; Stefan Gustafsson; Tuomas O Kilpeläinen; Jian Yang; Nabila Bouatia-Naji; Tõnu Esko; Mary F Feitosa; Zoltán Kutalik; Massimo Mangino; Soumya Raychaudhuri; Andre Scherag; Albert Vernon Smith; Ryan Welch; Jing Hua Zhao; Katja K Aben; Devin M Absher; Najaf Amin; Anna L Dixon; Eva Fisher; Nicole L Glazer; Michael E Goddard; Nancy L Heard-Costa; Volker Hoesel; Jouke-Jan Hottenga; Asa Johansson; Toby Johnson; Shamika Ketkar; Claudia Lamina; Shengxu Li; Miriam F Moffatt; Richard H Myers; Narisu Narisu; John R B Perry; Marjolein J Peters; Michael Preuss; Samuli Ripatti; Fernando Rivadeneira; Camilla Sandholt; Laura J Scott; Nicholas J Timpson; Jonathan P Tyrer; Sophie van Wingerden; Richard M Watanabe; Charles C White; Fredrik Wiklund; Christina Barlassina; Daniel I Chasman; Matthew N Cooper; John-Olov Jansson; Robert W Lawrence; Niina Pellikka; Inga Prokopenko; Jianxin Shi; Elisabeth Thiering; Helene Alavere; Maria T S Alibrandi; Peter Almgren; Alice M Arnold; Thor Aspelund; Larry D Atwood; Beverley Balkau; Anthony J Balmforth; Amanda J Bennett; Yoav Ben-Shlomo; Richard N Bergman; Sven Bergmann; Heike Biebermann; Alexandra I F Blakemore; Tanja Boes; Lori L Bonnycastle; Stefan R Bornstein; Morris J Brown; Thomas A Buchanan; Fabio Busonero; Harry Campbell; Francesco P Cappuccio; Christine Cavalcanti-Proença; Yii-Der Ida Chen; Chih-Mei Chen; Peter S Chines; Robert Clarke; Lachlan Coin; John Connell; Ian N M Day; Martin den Heijer; Jubao Duan; Shah Ebrahim; Paul Elliott; Roberto Elosua; Gudny Eiriksdottir; Michael R Erdos; Johan G Eriksson; Maurizio F Facheris; Stephan B Felix; Pamela Fischer-Posovszky; Aaron R Folsom; Nele Friedrich; Nelson B Freimer; Mao Fu; Stefan Gaget; Pablo V Gejman; Eco J C Geus; Christian Gieger; Anette P Gjesing; Anuj Goel; Philippe Goyette; Harald Grallert; Jürgen Grässler; Danielle M Greenawalt; Christopher J Groves; Vilmundur Gudnason; Candace Guiducci; Anna-Liisa Hartikainen; Neelam Hassanali; Alistair S Hall; Aki S Havulinna; Caroline Hayward; Andrew C Heath; Christian Hengstenberg; Andrew A Hicks; Anke Hinney; Albert Hofman; Georg Homuth; Jennie Hui; Wilmar Igl; Carlos Iribarren; Bo Isomaa; Kevin B Jacobs; Ivonne Jarick; Elizabeth Jewell; Ulrich John; Torben Jørgensen; Pekka Jousilahti; Antti Jula; Marika Kaakinen; Eero Kajantie; Lee M Kaplan; Sekar Kathiresan; Johannes Kettunen; Leena Kinnunen; Joshua W Knowles; Ivana Kolcic; Inke R König; Seppo Koskinen; Peter Kovacs; Johanna Kuusisto; Peter Kraft; Kirsti Kvaløy; Jaana Laitinen; Olivier Lantieri; Chiara Lanzani; Lenore J Launer; Cecile Lecoeur; Terho Lehtimäki; Guillaume Lettre; Jianjun Liu; Marja-Liisa Lokki; Mattias Lorentzon; Robert N Luben; Barbara Ludwig; Paolo Manunta; Diana Marek; Michel Marre; Nicholas G Martin; Wendy L McArdle; Anne McCarthy; Barbara McKnight; Thomas Meitinger; Olle Melander; David Meyre; Kristian Midthjell; Grant W Montgomery; Mario A Morken; Andrew P Morris; Rosanda Mulic; Julius S Ngwa; Mari Nelis; Matt J Neville; Dale R Nyholt; Christopher J O'Donnell; Stephen O'Rahilly; Ken K Ong; Ben Oostra; Guillaume Paré; Alex N Parker; Markus Perola; Irene Pichler; Kirsi H Pietiläinen; Carl G P Platou; Ozren Polasek; Anneli Pouta; Suzanne Rafelt; Olli Raitakari; Nigel W Rayner; Martin Ridderstråle; Winfried Rief; Aimo Ruokonen; Neil R Robertson; Peter Rzehak; Veikko Salomaa; Alan R Sanders; Manjinder S Sandhu; Serena Sanna; Jouko Saramies; Markku J Savolainen; Susann Scherag; Sabine Schipf; Stefan Schreiber; Heribert Schunkert; Kaisa Silander; Juha Sinisalo; David S Siscovick; Jan H Smit; Nicole Soranzo; Ulla Sovio; Jonathan Stephens; Ida Surakka; Amy J Swift; Mari-Liis Tammesoo; Jean-Claude Tardif; Maris Teder-Laving; Tanya M Teslovich; John R Thompson; Brian Thomson; Anke Tönjes; Tiinamaija Tuomi; Joyce B J van Meurs; Gert-Jan van Ommen; Vincent Vatin; Jorma Viikari; Sophie Visvikis-Siest; Veronique Vitart; Carla I G Vogel; Benjamin F Voight; Lindsay L Waite; Henri Wallaschofski; G Bragi Walters; Elisabeth Widen; Susanna Wiegand; Sarah H Wild; Gonneke Willemsen; Daniel R Witte; Jacqueline C Witteman; Jianfeng Xu; Qunyuan Zhang; Lina Zgaga; Andreas Ziegler; Paavo Zitting; John P Beilby; I Sadaf Farooqi; Johannes Hebebrand; Heikki V Huikuri; Alan L James; Mika Kähönen; Douglas F Levinson; Fabio Macciardi; Markku S Nieminen; Claes Ohlsson; Lyle J Palmer; Paul M Ridker; Michael Stumvoll; Jacques S Beckmann; Heiner Boeing; Eric Boerwinkle; Dorret I Boomsma; Mark J Caulfield; Stephen J Chanock; Francis S Collins; L Adrienne Cupples; George Davey Smith; Jeanette Erdmann; Philippe Froguel; Henrik Grönberg; Ulf Gyllensten; Per Hall; Torben Hansen; Tamara B Harris; Andrew T Hattersley; Richard B Hayes; Joachim Heinrich; Frank B Hu; Kristian Hveem; Thomas Illig; Marjo-Riitta Jarvelin; Jaakko Kaprio; Fredrik Karpe; Kay-Tee Khaw; Lambertus A Kiemeney; Heiko Krude; Markku Laakso; Debbie A Lawlor; Andres Metspalu; Patricia B Munroe; Willem H Ouwehand; Oluf Pedersen; Brenda W Penninx; Annette Peters; Peter P Pramstaller; Thomas Quertermous; Thomas Reinehr; Aila Rissanen; Igor Rudan; Nilesh J Samani; Peter E H Schwarz; Alan R Shuldiner; Timothy D Spector; Jaakko Tuomilehto; Manuela Uda; André Uitterlinden; Timo T Valle; Martin Wabitsch; Gérard Waeber; Nicholas J Wareham; Hugh Watkins; James F Wilson; Alan F Wright; M Carola Zillikens; Nilanjan Chatterjee; Steven A McCarroll; Shaun Purcell; Eric E Schadt; Peter M Visscher; Themistocles L Assimes; Ingrid B Borecki; Panos Deloukas; Caroline S Fox; Leif C Groop; Talin Haritunians; David J Hunter; Robert C Kaplan; Karen L Mohlke; Jeffrey R O'Connell; Leena Peltonen; David Schlessinger; David P Strachan; Cornelia M van Duijn; H-Erich Wichmann; Timothy M Frayling; Unnur Thorsteinsdottir; Gonçalo R Abecasis; Inês Barroso; Michael Boehnke; Kari Stefansson; Kari E North; Mark I McCarthy; Joel N Hirschhorn; Erik Ingelsson; Ruth J F Loos
Journal:  Nat Genet       Date:  2010-10-10       Impact factor: 38.330

10.  Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery.

Authors:  Reedik Mägi; Sean Manning; Ahmed Yousseif; Andrea Pucci; Ferruccio Santini; Efthimia Karra; Giorgia Querci; Caterina Pelosini; Mark I McCarthy; Cecilia M Lindgren; Rachel L Batterham
Journal:  PLoS One       Date:  2013-08-07       Impact factor: 3.240
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  9 in total

Review 1.  Precision behavioral medicine: Implications of genetic and genomic discoveries for behavioral weight loss treatment.

Authors:  Jeanne M McCaffery
Journal:  Am Psychol       Date:  2018-11

2.  Translation initiation in mammalian mitochondria- a prokaryotic perspective.

Authors:  Shreya Ahana Ayyub; Umesh Varshney
Journal:  RNA Biol       Date:  2019-11-14       Impact factor: 4.652

3.  Analysis of Gene Candidate SNP and Ancestral Origin Associated to Obesity and Postoperative Weight Loss in a Cohort of Obese Patients Undergoing RYGB.

Authors:  David Velázquez-Fernández; Gabriela Mercado-Celis; Jeny Flores-Morales; Diana Clavellina-Gaytán; Ramón Vidrio; Eduardo Vidrio; Maureen Mosti; Hugo Sánchez-Aguilar; Donaji Rodriguez; Pablo León; Miguel F Herrera
Journal:  Obes Surg       Date:  2017-06       Impact factor: 4.129

Review 4.  A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery.

Authors:  Sapana R Gupta; Yingjie Zhou; Thomas A Wadden; Robert I Berkowitz; Ariana M Chao
Journal:  Obes Surg       Date:  2021-08-09       Impact factor: 4.129

5.  Polygenic risk score for predicting weight loss after bariatric surgery.

Authors:  Juan de Toro-Martín; Frédéric Guénard; André Tchernof; Louis Pérusse; Simon Marceau; Marie-Claude Vohl
Journal:  JCI Insight       Date:  2018-09-06

6.  A Genetic Risk Score for the Estimation of Weight Loss After Bariatric Surgery.

Authors:  E A Katsareli; C Amerikanou; K Rouskas; A Dimopoulos; T Diamantis; A Alexandrou; J Griniatsos; S Bourgeois; E Dermitzakis; J Ragoussis; A S Dimas; G V Dedoussis
Journal:  Obes Surg       Date:  2020-04       Impact factor: 4.129

Review 7.  Strategies to Understand the Weight-Reduced State: Genetics and Brain Imaging.

Authors:  Ruth J F Loos; Charles Burant; Ellen A Schur
Journal:  Obesity (Silver Spring)       Date:  2021-04       Impact factor: 5.002

8.  Physiology of the Weight-Reduced State: A Report from a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Authors:  Maren R Laughlin; Stavroula K Osganian; Susan Z Yanovski; Christopher J Lynch
Journal:  Obesity (Silver Spring)       Date:  2021-04       Impact factor: 9.298

Review 9.  From genetics and epigenetics to the future of precision treatment for obesity.

Authors:  Xulong Sun; Pengzhou Li; Xiangwu Yang; Weizheng Li; Xianjie Qiu; Shaihong Zhu
Journal:  Gastroenterol Rep (Oxf)       Date:  2017-10-24
  9 in total

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