Literature DB >> 26335964

Impairment of exploratory behavior and spatial memory in adolescent rats in lithium-pilocarpine model of temporal lobe epilepsy.

S V Kalemenev1, O E Zubareva, E V Frolova, V V Sizov, V V Lavrentyeva, N Ya Lukomskaya, K Kh Kim, A V Zaitsev, L G Magazanik.   

Abstract

Cognitive impairment in six-week -old rats has been studied in the lithium-pilocarpine model of adolescent temporal lobe epilepsy in humans. The pilocarpine-treated rats (n =21) exhibited (a) a decreased exploratory activity in comparison with control rats (n = 20) in the open field (OP) test and (b) a slower extinction of exploratory behavior in repeated OP tests. The Morris Water Maze (MWM) test showed that the effect of training was less pronounced in the pilocarpine-treated rats, which demonstrated disruption of predominantly short-term memory. Therefore, our study has shown that lithium-pilocarpine seizures induce substantial changes in exploratory behavior and spatial memory in adolescent rats. OP and MWM tests can be used in the search of drugs reducing cognitive impairments associated with temporal lobe epilepsy.

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Year:  2015        PMID： 26335964     DOI： 10.1134/S0012496615040055

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  10 in total

1.  Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?

Authors:  C Helmstaedter; C E Elger
Journal:  Brain       Date:  2009-07-27       Impact factor: 13.501

Review 2.  Adolescence as a vulnerable period to alter rodent behavior.

Authors:  Miriam Schneider
Journal:  Cell Tissue Res       Date:  2013-02-22       Impact factor: 5.249

3.  [Morphofunctional changes in field CA1 of the rat hippocampus after pentylenetetrazole and lithium-pilocarpine induced seizures].

Authors:  D S Vasiliev; N L Tumanova; I A Zhuravin; K Kh Kim; N Ya Lukomskaya; L G Magazanik; A V Zaitsev
Journal:  Zh Evol Biokhim Fiziol       Date:  2014 Nov-Dec

4.  Memory in children with symptomatic temporal lobe epilepsy.

Authors:  Catarina A Guimãraes; Patricia Rzezak; Daniel Fuentes; Renata C Franzon; Maria Augusta Montenegro; Fernando Cendes; Kette D Valente; Marilisa M Guerreiro
Journal:  Arq Neuropsiquiatr       Date:  2014-03       Impact factor: 1.420

5.  [The influence of neonatal interleukin-1beta increase on the formation of adult rats' spatial memory].

Authors:  A N Trofimov; O E Zubareva; A S Simbirtsev; V M Klimenko
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  2012-06

6.  Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus.

Authors:  André Luiz do Nascimento; Neide Ferreira Dos Santos; Fernanda Campos Pelágio; Simone Aparecida Teixeira; Elenice A de Moraes Ferrari; Francesco Langone
Journal:  Brain Res       Date:  2012-07-08       Impact factor: 3.252

7.  [Interleukin-1beta and depressive states].

Authors:  O E Zubareva; O M Efremov; A S Simbirtsev; V M Klimenko
Journal:  Ross Fiziol Zh Im I M Sechenova       Date:  2001-10

8.  A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategories.

Authors:  Nihal C de Lanerolle; Jung H Kim; Anne Williamson; Susan S Spencer; Hitten P Zaveri; Tore Eid; Dennis D Spencer; Toye Eid
Journal:  Epilepsia       Date:  2003-05       Impact factor: 5.864

9.  Hippocampal-dependent spatial memory in the water maze is preserved in an experimental model of temporal lobe epilepsy in rats.

Authors:  Marion Inostroza; Elena Cid; Jorge Brotons-Mas; Beatriz Gal; Paloma Aivar; Yoryani G Uzcategui; Carmen Sandi; Liset Menendez de la Prida
Journal:  PLoS One       Date:  2011-07-26       Impact factor: 3.240

Review 10.  The pilocarpine model of temporal lobe epilepsy.

Authors:  Giulia Curia; Daniela Longo; Giuseppe Biagini; Roland S G Jones; Massimo Avoli
Journal:  J Neurosci Methods       Date:  2008-04-26       Impact factor: 2.390
  10 in total
  5 in total

1.  Memantine attenuates cognitive impairments after status epilepticus induced in a lithium-pilocarpine model.

Authors:  S V Kalemenev; O E Zubareva; V V Sizov; V V Lavrent'eva; N Ya Lukomskaya; K Kh Kim; A V Zaitsev; L G Magazanik
Journal:  Dokl Biol Sci       Date:  2016-11-08

2.  Alterations in Properties of Glutamatergic Transmission in the Temporal Cortex and Hippocampus Following Pilocarpine-Induced Acute Seizures in Wistar Rats.

Authors:  Dmitry V Amakhin; Sergey L Malkin; Julia L Ergina; Kirill A Kryukov; Ekaterina A Veniaminova; Olga E Zubareva; Aleksey V Zaitsev
Journal:  Front Cell Neurosci       Date:  2017-08-31       Impact factor: 5.505

3.  Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.

Authors:  Pabitra Hriday Patra; Melissa Barker-Haliski; H Steve White; Benjamin J Whalley; Sarah Glyn; Haramrit Sandhu; Nicholas Jones; Michael Bazelot; Claire M Williams; Alister James McNeish
Journal:  Epilepsia       Date:  2018-12-26       Impact factor: 5.864

Review 4.  DREADDs in Epilepsy Research: Network-Based Review.

Authors:  John-Sebastian Mueller; Fabio Cesar Tescarollo; Hai Sun
Journal:  Front Mol Neurosci       Date:  2022-04-07       Impact factor: 6.261

5.  Knockdown of Lingo-1 by short hairpin RNA promotes cognitive function recovery in a status convulsion model.

Authors:  Rong He; Wei Han; Xiaojie Song; Li Cheng; Hengsheng Chen; Li Jiang
Journal:  3 Biotech       Date:  2021-06-16       Impact factor: 2.893
  5 in total

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