Andrei V Iosub1, Shannon S Stahl1. 1. Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706, United States.
Abstract
Dehydrogenation of (partially) saturated heterocycles provides an important route to heteroaromatic compounds. A heterogeneous cobalt oxide catalyst, previously employed for aerobic oxidation of alcohols and amines, is shown to be effective for aerobic dehydrogenation of various 1,2,3,4-tetrahydroquinolines to the corresponding quinolines. The reactions proceed in good yields under mild conditions. Other N-heterocycles are also successfully oxidized to their aromatic counterparts.
Dehydrogenation of (partially) saturated heterocycles provides an important route to heteron class="Chemical">aromatic compounds. A heterogeneous cobalt oxide catalyst, previously employed for aerobic oxidation of alcohols and amines, is shown to be effective for aerobic dehydrogenation of various 1,2,3,4-tetrahydroquinolines to the corresponding quinolines. The reactions proceed in good yields under mild conditions. Other N-heterocyclesare also successfully oxidized to their aromatic counterparts.
Authors: Patrick R Verhoest; Douglas S Chapin; Michael Corman; Kari Fonseca; John F Harms; Xinjun Hou; Eric S Marr; Frank S Menniti; Frederick Nelson; Rebecca O'Connor; Jayvardhan Pandit; Caroline Proulx-Lafrance; Anne W Schmidt; Christopher J Schmidt; Judith A Suiciak; Spiros Liras Journal: J Med Chem Date: 2009-08-27 Impact factor: 7.446
Authors: Tejas M Dhameliya; Hiren A Donga; Punit V Vaghela; Bhoomi G Panchal; Dipen K Sureja; Kunjan B Bodiwala; Mahesh T Chhabria Journal: RSC Adv Date: 2020-09-03 Impact factor: 4.036