Nan-Kai Wang1,2, Chi-Chun Lai1,2, Jung-Pan Wang3,4, Wei-Chi Wu1,2, Laura Liu1,2, Lung-Kun Yeh1,2, Hsiao-Jung Tseng5, Chee-Jen Chang5,6,7, Fu-Sung Lo1,8. 1. Department of Medicine, Chang Gung University, College of Medicine, Taoyuan, Taiwan. 2. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan. 3. School of Medicine, National Yang-Ming University, Taipei, Taiwan. 4. Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan. 5. Biostatistical Center for Clinical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 6. Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan. 7. Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan, Taiwan. 8. Division of Pediatric Endocrinology and Genetics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Abstract
BACKGROUND: The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan. METHODS: This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self-reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball. RESULTS: There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional-hazards analysis showed that older-onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration. CONCLUSIONS: Development of retinopathy 10 yr after diagnosis in people with juvenile-onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.
BACKGROUND: The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan. METHODS: This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self-reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball. RESULTS: There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional-hazards analysis showed that older-onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration. CONCLUSIONS: Development of retinopathy 10 yr after diagnosis in people with juvenile-onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.
Authors: Pablo Alvarez-Ramos; Soledad Jimenez-Carmona; Pedro Alemany-Marquez; Juan Antonio Cordoba-Doña; Manuel Aguilar-Diosdado Journal: BMJ Open Diabetes Res Care Date: 2020-11