Literature DB >> 26330927

Treatment of Verruca Vulgaris in Both External Auditory Canals Using Bleomycin Injections.

Jun Hee Lee1, Jin Sik Burm1, Won Yong Yang1, Sang Yoon Kang1, Sung Wan Byun2.   

Abstract

Verruca vulgaris is caused by human papillomavirus (HPV) infections. Verruca in the external auditory canal (EAC) has rarely been reported. A previous case report introduced surgical excision as a treatment for verruca in the EAC. We present a case of verruca vulgaris in both EACs that was successfully treated with an intralesional bleomycin injection. A 32-year-old male patient presented with ear fullness and palpable lumps in both EACs. Both of his canals were filled with multiple pinkish, papillomatous masses. Verruca vulgaris was confirmed by skin biopsy. An otolaryngologist referred this patient and recommended surgical excision. However, we performed intralesional bleomycin injections for treatment. Twice intralesional bleomycin injections at one-month intervals had excellent results without recurrence, ulceration or scar formation. This result indicates that bleomycin injections may prove to be an effective first-line treatment of verruca in the EAC.

Entities:  

Keywords:  Bleomycin; Warts

Year:  2015        PMID: 26330927      PMCID: PMC4553363          DOI: 10.3342/ceo.2015.8.3.295

Source DB:  PubMed          Journal:  Clin Exp Otorhinolaryngol        ISSN: 1976-8710            Impact factor:   3.372


  10 in total

1.  Guidelines for the management of cutaneous warts.

Authors:  J C Sterling; S Handfield-Jones; P M Hudson
Journal:  Br J Dermatol       Date:  2001-01       Impact factor: 9.302

2.  Huge verruca vulgaris (wart) of the external auditory canal.

Authors:  Joohwan Kim; Dong-Hee Lee; Kwang-Jae Cho; Se-Yoon Lee
Journal:  Otolaryngol Head Neck Surg       Date:  2008-12       Impact factor: 3.497

3.  Papillomas of the external ear canal: report of ten cases in Chinese patients with HPV in situ hybridization.

Authors:  Shuyi Wang; Herman Yee; Hannah Y Wen; Beverly Y Wang
Journal:  Head Neck Pathol       Date:  2009-08-02

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Authors:  S Mizuno; A Ishida
Journal:  Biochem Biophys Res Commun       Date:  1982-03-30       Impact factor: 3.575

Review 5.  Bleomycin and the skin.

Authors:  T Yamamoto
Journal:  Br J Dermatol       Date:  2006-11       Impact factor: 9.302

6.  Histologic, pharmacologic, and immunocytochemical effects of injection of bleomycin into viral warts.

Authors:  M P James; P M Collier; W Aherne; A Hardcastle; S Lovegrove
Journal:  J Am Acad Dermatol       Date:  1993-06       Impact factor: 11.527

Review 7.  Bleomycin in dermatology: a review of intralesional applications.

Authors:  Peter Saitta; Karthik Krishnamurthy; Lance H Brown
Journal:  Dermatol Surg       Date:  2008-06-27       Impact factor: 3.398

8.  Intradermal bleomycin injections into normal human skin. A histopathologic and immunopathologic study.

Authors:  S F Templeton; A R Solomon; R A Swerlick
Journal:  Arch Dermatol       Date:  1994-05

9.  Squamous papilloma in the external auditory canal: A common lesion in an uncommon site.

Authors:  Ning-Chia Chang; Chen-Yu Chien; Chun-Chieh Wu; Chee-Yin Chai
Journal:  World J Clin Cases       Date:  2013-05-16       Impact factor: 1.337

10.  Ultrastructure and human papillomavirus DNA in papillomatosis of external auditory canal.

Authors:  M Y Xia; W Y Zhu; J Y Lu; Q Lu; L Chen
Journal:  Int J Dermatol       Date:  1996-05       Impact factor: 2.736

  10 in total
  1 in total

1.  Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study.

Authors:  Paola Pasquali; Azael Freites-Martinez; Salvador Gonzalez; Enrico P Spugnini; Alfonso Baldi
Journal:  Dermatol Pract Concept       Date:  2017-07-31
  1 in total

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