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Literature DB >> 26329430

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.

Abstract

Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.

Entities: Chemical Disease Gene Mutation Species

Keywords: Dopamine; Iron; PLMS; RLS augmentation; RLS/WED

Mesh：

Substances：
Iron
Dopamine

Year: 2015 PMID： 26329430 PMCID： PMC4559751 DOI： 10.1016/j.jsmc.2015.05.022

Source DB: PubMed Journal: Sleep Med Clin ISSN： 1556-407X

62 in total

1. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies.

Authors: N Turjanski; A J Lees; D J Brooks
Journal: Neurology Date: 1999-03-23 Impact factor: 9.910

2. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding.

Authors: Simon Cervenka; Sven E Pålhagen; Robert A Comley; Georgios Panagiotidis; Zsolt Cselényi; Julian C Matthews; Robert Y Lai; Christer Halldin; Lars Farde
Journal: Brain Date: 2006-07-01 Impact factor: 13.501

3. Changes of cortical excitability after dopaminergic treatment in restless legs syndrome.

Authors: Anna Scalise; Italo Pittaro-Cadore; Francesco Janes; Roberto Marinig; Gian Luigi Gigli
Journal: Sleep Med Date: 2010-01 Impact factor: 3.492

Review 4. Distinctive patterns of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome, restless legs syndrome, insomnia, and sleep deprivation.

Authors: Giuseppe Lanza; Mariagiovanna Cantone; Bartolo Lanuzza; Manuela Pennisi; Rita Bella; Giovanni Pennisi; Raffaele Ferri
Journal: Sleep Med Rev Date: 2014-04-13 Impact factor: 11.609

5. Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study.

Authors: Wolfgang Oertel; Claudia Trenkwalder; Heike Beneš; Luigi Ferini-Strambi; Birgit Högl; Werner Poewe; Karin Stiasny-Kolster; Andreas Fichtner; Erwin Schollmayer; Ralf Kohnen; Diego García-Borreguero
Journal: Lancet Neurol Date: 2011-06-24 Impact factor: 44.182

6. Iron deficiency alters dopamine transporter functioning in rat striatum.

Authors: K M Erikson; B C Jones; J L Beard
Journal: J Nutr Date: 2000-11 Impact factor: 4.798

7. Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease).

Authors: Aaro V Salminen; Ville Rimpilä; Olli Polo
Journal: Neurology Date: 2014-04-30 Impact factor: 9.910

8. Normal dopaminergic and serotonergic metabolites in cerebrospinal fluid and blood of restless legs syndrome patients.

Authors: Karin Stiasny-Kolster; J Carsten Möller; Johannes Zschocke; Oliver Bandmann; Werner Cassel; Wolfgang H Oertel; Georg F Hoffmann
Journal: Mov Disord Date: 2004-02 Impact factor: 10.338

9. Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging.

Authors: Alexander Unrath; Hans-Peter Müller; Albert C Ludolph; Axel Riecker; Jan Kassubek
Journal: Mov Disord Date: 2008-07-15 Impact factor: 10.338

10. T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome.

Authors: Hye-Jin Moon; Yongmin Chang; Yeong Seon Lee; Hee Jin Song; Hyuk Won Chang; Jeonghun Ku; Yong Won Cho
Journal: J Clin Neurol Date: 2014-07-03 Impact factor: 3.077

30 in total

Review 9. Iron therapy in heart failure patients without anaemia: possible implications for chronic kidney disease patients.

Authors: Jolanta Malyszko; Stefan D Anker
Journal: Clin Kidney J Date: 2017-11-28

10. Electrophysiological findings of Turkish patients with restless legs syndrome.

Authors: Ahmet Özsimsek; Hasan Rifat Koyuncuoglu
Journal: Neuropsychiatr Dis Treat Date: 2017-07-27 Impact factor: 2.570

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.

1. Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies.

2. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding.

3. Changes of cortical excitability after dopaminergic treatment in restless legs syndrome.

Review 4. Distinctive patterns of cortical excitability to transcranial magnetic stimulation in obstructive sleep apnea syndrome, restless legs syndrome, insomnia, and sleep deprivation.

5. Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study.

6. Iron deficiency alters dopamine transporter functioning in rat striatum.

7. Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease).

8. Normal dopaminergic and serotonergic metabolites in cerebrospinal fluid and blood of restless legs syndrome patients.

9. Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging.

10. T2 relaxometry using 3.0-tesla magnetic resonance imaging of the brain in early- and late-onset restless legs syndrome.

1. Seeking the Cause of Restless Legs Syndrome in Chronic Kidney Disease.

2. Restless legs syndrome and its variants: a case report.

Review 3. Gabapentin treatment in clozapine-induced restless legs syndrome: two cases and a review of the literature.

Review 4. Brain imaging and networks in restless legs syndrome.

Review 5. Iron, dopamine, genetics, and hormones in the pathophysiology of restless legs syndrome.

Review 6. Update on Restless Legs Syndrome: from Mechanisms to Treatment.

Review 7. Restless Sleep Disorder (RSD): a New Sleep Disorder in Children. A Rapid Review.

Review 8. Restless Legs Syndrome: Contemporary Diagnosis and Treatment.

Review 9. Iron therapy in heart failure patients without anaemia: possible implications for chronic kidney disease patients.

10. Electrophysiological findings of Turkish patients with restless legs syndrome.