Literature DB >> 26325491

Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes.

Alok Sharma1, Hieu Nguyen, Lu Cai, Hua Lou.   

Abstract

In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms controlling activity-dependent alternative splicing is under-studied and not well understood. In a recent study, we conducted a comprehensive analysis of calcium-mediated mechanism that regulates alternative exon skipping in mouse cardiomyocytes. Our results reveal a strong link between histone hyperacetylation and skipping of cassette exons, and provide support to the kinetic coupling model of the epigenetic regulation of alternative splicing at the chromatin level.

Entities:  

Keywords:  CaMK; PKD; alternative splicing; calcium; class II HDAC; exon skipping; histone hyperacetylation

Mesh：

Substances：

Year:  2015        PMID： 26325491      PMCID： PMC4615673          DOI： 10.1080/19491034.2015.1081324

Source DB:  PubMed          Journal:  Nucleus        ISSN： 1949-1034            Impact factor:   4.197


  38 in total

1.  A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels.

Authors:  J Xie; D L Black
Journal:  Nature       Date:  2001-04-19       Impact factor: 49.962

2.  The human SWI/SNF subunit Brm is a regulator of alternative splicing.

Authors:  Eric Batsché; Moshe Yaniv; Christian Muchardt
Journal:  Nat Struct Mol Biol       Date:  2005-12-11       Impact factor: 15.369

3.  DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

Authors:  Manuel J Muñoz; M Soledad Pérez Santangelo; Maria P Paronetto; Manuel de la Mata; Federico Pelisch; Stéphanie Boireau; Kira Glover-Cutter; Claudia Ben-Dov; Matías Blaustein; Juan J Lozano; Gregory Bird; David Bentley; Edouard Bertrand; Alberto R Kornblihtt
Journal:  Cell       Date:  2009-05-15       Impact factor: 41.582

4.  Evidence for regulation of mitochondrial function by the L-type Ca2+ channel in ventricular myocytes.

Authors:  Helena M Viola; Peter G Arthur; Livia C Hool
Journal:  J Mol Cell Cardiol       Date:  2009-01-07       Impact factor: 5.000

Review 5.  50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond.

Authors:  Eric Verdin; Melanie Ott
Journal:  Nat Rev Mol Cell Biol       Date:  2014-12-30       Impact factor: 94.444

6.  CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy.

Authors:  Johannes Backs; Kunhua Song; Svetlana Bezprozvannaya; Shurong Chang; Eric N Olson
Journal:  J Clin Invest       Date:  2006-06-08       Impact factor: 14.808

Review 7.  Epigenetics in alternative pre-mRNA splicing.

Authors:  Reini F Luco; Mariano Allo; Ignacio E Schor; Alberto R Kornblihtt; Tom Misteli
Journal:  Cell       Date:  2011-01-07       Impact factor: 41.582

8.  Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

Authors:  Florian Heyd; Kristen W Lynch
Journal:  Mol Cell       Date:  2010-10-08       Impact factor: 17.970

9.  The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca2+/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats.

Authors:  Jiankun Yu; Yan Hai; Guodong Liu; Tielan Fang; Sam K P Kung; Jiuyong Xie
Journal:  J Biol Chem       Date:  2008-11-18       Impact factor: 5.157

10.  Exon expression profiling reveals stimulus-mediated exon use in neural cells.

Authors:  Adrienne E McKee; Nicola Neretti; Luis E Carvalho; Clifford A Meyer; Edward A Fox; Alexander S Brodsky; Pamela A Silver
Journal:  Genome Biol       Date:  2007       Impact factor: 13.583
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  5 in total

1.  Neurofibromatosis type 1 alternative splicing is a key regulator of Ras/ERK signaling and learning behaviors in mice.

Authors:  Hieu T Nguyen; Melissa N Hinman; Xuan Guo; Alok Sharma; Hiroyuki Arakawa; Guangbin Luo; Hua Lou
Journal:  Hum Mol Genet       Date:  2017-10-01       Impact factor: 6.150

2.  Alternative splicing links histone modifications to stem cell fate decision.

Authors:  Yungang Xu; Weiling Zhao; Scott D Olson; Karthik S Prabhakara; Xiaobo Zhou
Journal:  Genome Biol       Date:  2018-09-14       Impact factor: 13.583

3.  Regulation of alternative splicing by p300-mediated acetylation of splicing factors.

Authors:  Ahmad Siam; Mai Baker; Leah Amit; Gal Regev; Alona Rabner; Rauf Ahmad Najar; Mercedes Bentata; Sara Dahan; Klil Cohen; Sarah Araten; Yuval Nevo; Gillian Kay; Yael Mandel-Gutfreund; Maayan Salton
Journal:  RNA       Date:  2019-04-15       Impact factor: 4.942

4.  Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment.

Authors:  Siyuan Chang; Jing Huang; Huan Niu; Jing Wang; Yang Si; Zhigang Bai; Shan Cheng; Wei Ding
Journal:  Cancer Cell Int       Date:  2020-09-14       Impact factor: 5.722

5.  Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease.

Authors:  Wen-Hsin Chang; Dau-Ming Niu; Chi-Yu Lu; Shyr-Yi Lin; Ta-Chih Liu; Jan-Gowth Chang
Journal:  PLoS One       Date:  2017-04-21       Impact factor: 3.240
  5 in total

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