Literature DB >> 26325314

Improved pharmacokinetics and enhanced tumor growth inhibition using a nanostructured lipid carrier loaded with doxorubicin and modified with a layer-by-layer polyelectrolyte coating.

Samuel V Mussi1, Gaurav Parekh2, Pravin Pattekari2, Tatyana Levchenko1, Yuri Lvov2, Lucas A M Ferreira3, Vladimir P Torchilin4.   

Abstract

A nanostructured lipid carrier (NLC) loaded with doxorubicin (DOX) has been shown to be cytotoxic against the human cancer cell lines A549 and MCF-7/Adr. In attempts to improve formulation characteristics, enhance pharmacokinetics and antitumor effects, we modified the surface of these NLC with an alternating layer-by-layer (LbL) assembly of polycation and polyanion polyelectrolytes and an additional coating with PEG using a simple method of core shell attachment. The formulation had a narrow size distribution, longer residence in the blood, lower accumulation in the liver, higher accumulation in tumors and a significant tumor growth inhibition effect. Thus, NLC-DOX nanopreparations complexes modified by LbL coating have the potential to enhance the anticancer effects of DOX against tumors.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Doxorubicin; Drug delivery; In vivo; LbL; Nanostructured lipid carrier

Mesh：

Substances：

Year:  2015        PMID： 26325314      PMCID： PMC4609627          DOI： 10.1016/j.ijpharm.2015.08.079

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  11 in total

1.  Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer.

Authors:  Xiao-Yan Yang; Yun-Xia Li; Min Li; Li Zhang; Li-Xia Feng; Na Zhang
Journal:  Cancer Lett       Date:  2012-07-07       Impact factor: 8.679

Review 2.  Multifunctional nanocarriers.

Authors:  Vladimir P Torchilin
Journal:  Adv Drug Deliv Rev       Date:  2006-09-28       Impact factor: 15.470

3.  Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery.

Authors:  Thiruganesh Ramasamy; Tuan Hiep Tran; Ju Yeon Choi; Hyuk Jun Cho; Jeong Hwan Kim; Chul Soon Yong; Han-Gon Choi; Jong Oh Kim
Journal:  Carbohydr Polym       Date:  2013-11-13       Impact factor: 9.381

4.  Layer-by-layer nanoencapsulation of camptothecin with improved activity.

Authors:  Gaurav Parekh; Pravin Pattekari; Chaitanya Joshi; Tatsiana Shutava; Mark DeCoster; Tatyana Levchenko; Vladimir Torchilin; Yuri Lvov
Journal:  Int J Pharm       Date:  2014-02-06       Impact factor: 5.875

5.  Architectural layer-by-layer assembly of drug nanocapsules with PEGylated polyelectrolytes.

Authors:  Tatsiana G Shutava; Pravin P Pattekari; Kirill A Arapov; Vladimir P Torchilin; Yuri M Lvov
Journal:  Soft Matter       Date:  2012-06-25       Impact factor: 3.679

6.  Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells.

Authors:  Samuel V Mussi; Rupa Sawant; Federico Perche; Mônica C Oliveira; Ricardo B Azevedo; Lucas A M Ferreira; Vladimir P Torchilin
Journal:  Pharm Res       Date:  2014-02-13       Impact factor: 4.200

Review 7.  Lipid nanoparticles for parenteral delivery of actives.

Authors:  Medha D Joshi; Rainer H Müller
Journal:  Eur J Pharm Biopharm       Date:  2008-09-13       Impact factor: 5.571

8.  Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells.

Authors:  Xing-Guo Zhang; Jing Miao; You-Qin Dai; Yong-Zhong Du; Hong Yuan; Fu-Qiang Hu
Journal:  Int J Pharm       Date:  2008-06-07       Impact factor: 5.875

9.  New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles.

Authors:  Samuel Vidal Mussi; Renata Carvalho Silva; Mônica Cristina de Oliveira; Carolina Madeira Lucci; Ricardo Bentes de Azevedo; Lucas Antônio Miranda Ferreira
Journal:  Eur J Pharm Sci       Date:  2012-11-20       Impact factor: 4.384

10.  Enhanced tumor delivery and antitumor activity in vivo of liposomal doxorubicin modified with MCF-7-specific phage fusion protein.

Authors:  Tao Wang; William C Hartner; James W Gillespie; Kulkarni P Praveen; Shenghong Yang; Leslie A Mei; Valery A Petrenko; Vladimir P Torchilin
Journal:  Nanomedicine       Date:  2013-09-09       Impact factor: 5.307
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  4 in total

Review 1.  Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach.

Authors:  Ketki Bhise; Sushil Kumar Kashaw; Samaresh Sau; Arun K Iyer
Journal:  Int J Pharm       Date:  2017-05-11       Impact factor: 5.875

2.  Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach.

Authors:  Yi-Hsien Cheng; Chunla He; Jim E Riviere; Nancy A Monteiro-Riviere; Zhoumeng Lin
Journal:  ACS Nano       Date:  2020-03-04       Impact factor: 15.881

Review 3.  Antineoplastics Encapsulated in Nanostructured Lipid Carriers.

Authors:  Gustavo Henrique Rodrigues da Silva; Ludmilla David de Moura; Fabíola Vieira de Carvalho; Gabriela Geronimo; Talita Cesarim Mendonça; Fernando Freitas de Lima; Eneida de Paula
Journal:  Molecules       Date:  2021-11-17       Impact factor: 4.411

4.  Hyaluronic Acid Modified Nanostructured Lipid Carrier for Targeting Delivery of Kaempferol to NSCLC: Preparation, Optimization, Characterization, and Performance Evaluation In Vitro.

Authors:  Yufei Ma; Jinli Liu; Xinyu Cui; Jiafu Hou; Fengbo Yu; Jinghua Wang; Xiaoxue Wang; Cong Chen; Lei Tong
Journal:  Molecules       Date:  2022-07-17       Impact factor: 4.927
  4 in total

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