Literature DB >> 18824097

Lipid nanoparticles for parenteral delivery of actives.

Medha D Joshi1, Rainer H Müller.   

Abstract

The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugates (LDC) in parenteral delivery of pharmaceutical actives. The attempts to incorporate anticancer agents, imaging agents, antiparasitics, antiarthritics, genes for transfection, agents for liver, cardiovascular and central nervous system targeting have been summarized. The utility of lipid nanoparticles as adjuvant has been discussed separately. A special focus of this review is on toxicity caused by these kinds of lipid nanoparticles with a glance on the fate of lipid nanoparticles after their parenteral delivery in vivo viz the protein adsorption patterns.

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Year:  2008        PMID： 18824097     DOI： 10.1016/j.ejpb.2008.09.003

Source DB:  PubMed          Journal:  Eur J Pharm Biopharm        ISSN： 0939-6411            Impact factor:   5.571


  50 in total

1.  Nanostructured lipid carriers (NLC) for parenteral delivery of an anticancer drug.

Authors:  Akhayacatra Chinsriwongkul; Ponwanit Chareanputtakhun; Tanasait Ngawhirunpat; Theerasak Rojanarata; Warisada Sila-on; Uracha Ruktanonchai; Praneet Opanasopit
Journal:  AAPS PharmSciTech       Date:  2011-12-14       Impact factor: 3.246

Review 2.  Nanoparticulate systems for drug delivery and targeting to the central nervous system.

Authors:  Emanuela Fabiola Craparo; Maria Luisa Bondì; Giovanna Pitarresi; Gennara Cavallaro
Journal:  CNS Neurosci Ther       Date:  2010-10-15       Impact factor: 5.243

3.  Modulation of Pharmacokinetic and Cytotoxicity Profile of Imatinib Base by Employing Optimized Nanostructured Lipid Carriers.

Authors:  Biki Gupta; Bijay Kumar Poudel; Tuan Hiep Tran; Roshan Pradhan; Hyuk-Jun Cho; Jee-Heon Jeong; Beom Soo Shin; Han-Gon Choi; Chul Soon Yong; Jong Oh Kim
Journal:  Pharm Res       Date:  2015-05-05       Impact factor: 4.200

4.  Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications.

Authors:  Xiomara Calderón-Colón; Giorgio Raimondi; Jason J Benkoski; Julia B Patrone
Journal:  J Vis Exp       Date:  2015-11-17       Impact factor: 1.355

Review 5.  Nanoparticles and the immune system.

Authors:  Banu S Zolnik; Africa González-Fernández; Nakissa Sadrieh; Marina A Dobrovolskaia
Journal:  Endocrinology       Date:  2009-12-16       Impact factor: 4.736

6.  Liposome encapsulation of thiol-capped CdTe quantum dots for enhancing the intracellular delivery.

Authors:  Jun-Yong Wang; Jin-Feng Zhao; Pei-Nan Wang; Wu-Li Yang; Ji-Yao Chen
Journal:  J Fluoresc       Date:  2011-03-16       Impact factor: 2.217

Review 7.  Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging.

Authors:  Sonu Bhaskar; Furong Tian; Tobias Stoeger; Wolfgang Kreyling; Jesús M de la Fuente; Valeria Grazú; Paul Borm; Giovani Estrada; Vasilis Ntziachristos; Daniel Razansky
Journal:  Part Fibre Toxicol       Date:  2010-03-03       Impact factor: 9.400

Review 8.  Nanocarrier for poorly water-soluble anticancer drugs--barriers of translation and solutions.

Authors:  Mayuri Narvekar; Hui Yi Xue; June Young Eoh; Ho Lun Wong
Journal:  AAPS PharmSciTech       Date:  2014-04-02       Impact factor: 3.246

9.  Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells.

Authors:  Samuel V Mussi; Rupa Sawant; Federico Perche; Mônica C Oliveira; Ricardo B Azevedo; Lucas A M Ferreira; Vladimir P Torchilin
Journal:  Pharm Res       Date:  2014-02-13       Impact factor: 4.200

10.  In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system.

Authors:  Min-ting Wang; Yun Jin; Yun-xia Yang; Chun-yan Zhao; Hong-yun Yang; Xue-fan Xu; Xuan Qin; Zhao-dan Wang; Zhi-rong Zhang; Yan-lin Jian; Yuan Huang
Journal:  Int J Nanomedicine       Date:  2010-08-09
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