Axel Van Der Gucht1, Antoine Verger2,3,4, Eric Guedj5,6, Grégoire Malandain7, Gabriela Hossu8,9, Yalcin Yagdigul2, Véronique Roch2,3,4, Sylvain Poussier2,3,4, Louis Maillard4,10, Gilles Karcher2,4,11, Pierre-Yves Marie2,4,12. 1. Department of Nuclear Medicine and Nancyclotep Experimental Imaging Platform, CHU Nancy, Allée du Morvan, Vandœuvre, 54000, Nancy, France. axel.vandergucht@gmail.com. 2. Department of Nuclear Medicine and Nancyclotep Experimental Imaging Platform, CHU Nancy, Allée du Morvan, Vandœuvre, 54000, Nancy, France. 3. INSERM, UMR 947, 54000, Nancy, France. 4. Faculty of Medicine, University of Lorraine, 54000, Nancy, France. 5. Department of Nuclear Medicine, AP-HM, Hospital "La Timone", 13000, Marseille, France. 6. CNRS UMR 7289, Institut de Neurosciences de la Timone, INT, 13000, Marseille, France. 7. INRIA Sophia Antipolis-Méditerranée, 06902, Sophia Antipolis, France. 8. CIC-IT, CHU Nancy, 5400, Nancy, France. 9. INSERM, CIC-IT 1433, 5400, Nancy, France. 10. Department of Neurology, CHU-Nancy, 54000, Nancy, France. 11. CRAN, UMR 7039, Université de Lorraine-CNRS, 54500, Vandoeuvre, France. 12. INSERM, U1116, 54000, Nancy, France.
Abstract
INTRODUCTION: The impact of age is crucial and must be taken into account when applying a voxel-based quantitative analysis on brain images from [¹⁸F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET). This study aimed to determine whether age-related changes in brain FDG-PET images are more accurately assessed when the conventional statistical parametric mapping (SPM) normalization method is used with an adaptive template, obtained from analysed PET images using a Block-Matching (BM) algorithm to fit with the characteristics of these images. METHODS: Age-related changes in FDG-PET images were computed with linear models in 84 neurologically healthy subjects (35 women, 19 to 82-year-old), and compared between results provided by the SPM normalization algorithm applied on its dedicated conventional template or on the adaptive BM template. A threshold P value of 0.05 was used together with a family-wise error correction. RESULTS: The age-related changes in FDG-PET images were much more apparent when computed with the adaptive template than with the conventional template as evidenced by: (1) stronger correlation coefficients with age for the overall frontal and temporal uptake values (respective R² values of 0.20 and 0.07) and (2) larger extents of involved areas (13 and 5% of whole brain template volume, respectively), leading to reveal several age-dependent areas (especially in dorsolateral prefrontal, inferior temporal/fusiform and primary somatosensory cortices). CONCLUSION: Age-related changes in brain FDG uptake may be more accurately determined when applying the SPM method of voxel-based quantitative analysis on a template that best fits the characteristics of the analysed TEP images.
INTRODUCTION: The impact of age is crucial and must be taken into account when applying a voxel-based quantitative analysis on brain images from [¹⁸F]-fluorodeoxyglucose Positron Emission Tomography (FDG-PET). This study aimed to determine whether age-related changes in brain FDG-PET images are more accurately assessed when the conventional statistical parametric mapping (SPM) normalization method is used with an adaptive template, obtained from analysed PET images using a Block-Matching (BM) algorithm to fit with the characteristics of these images. METHODS: Age-related changes in FDG-PET images were computed with linear models in 84 neurologically healthy subjects (35 women, 19 to 82-year-old), and compared between results provided by the SPM normalization algorithm applied on its dedicated conventional template or on the adaptive BM template. A threshold P value of 0.05 was used together with a family-wise error correction. RESULTS: The age-related changes in FDG-PET images were much more apparent when computed with the adaptive template than with the conventional template as evidenced by: (1) stronger correlation coefficients with age for the overall frontal and temporal uptake values (respective R² values of 0.20 and 0.07) and (2) larger extents of involved areas (13 and 5% of whole brain template volume, respectively), leading to reveal several age-dependent areas (especially in dorsolateral prefrontal, inferior temporal/fusiform and primary somatosensory cortices). CONCLUSION: Age-related changes in brain FDG uptake may be more accurately determined when applying the SPM method of voxel-based quantitative analysis on a template that best fits the characteristics of the analysed TEP images.
Authors: Sinn-Rithy Toch; Sylvain Poussier; Emilien Micard; Marc Bertaux; Axel Van Der Gucht; Elodie Chevalier; Pierre-Yves Marie; Eric Guedj; Antoine Verger Journal: Mol Imaging Biol Date: 2019-06 Impact factor: 3.488
Authors: Antoine Verger; Carina Stegmayr; Norbert Galldiks; Axel Van Der Gucht; Philipp Lohmann; Gabriele Stoffels; Nadim J Shah; Gereon R Fink; Simon B Eickhoff; Eric Guedj; Karl-Josef Langen Journal: Neuroimage Clin Date: 2017-11-08 Impact factor: 4.881