Sinn-Rithy Toch1, Sylvain Poussier1,2, Emilien Micard2, Marc Bertaux3, Axel Van Der Gucht4, Elodie Chevalier1, Pierre-Yves Marie1,5, Eric Guedj6,7,8, Antoine Verger9,10. 1. Department of Nuclear Medicine & Nancyclotep Imaging Platform, CHRU Nancy, Lorraine University, Nancy, France. 2. Lorraine University, INSERM, IADI, Nancy, France. 3. Department of Nuclear Medicine, APHP Pitié Salpêtrière, Paris, France. 4. Departments of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland. 5. INSERM, UMR 1116, Lorraine University, Nancy, France. 6. Aix Marseille Univ, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France. 7. Department of Biophysics & Nuclear Medicine, APHM Timone, Marseille, France. 8. European Research Center in Nuclear Medicine, CERIMED, Marseille, France. 9. Department of Nuclear Medicine & Nancyclotep Imaging Platform, CHRU Nancy, Lorraine University, Nancy, France. a.verger@chru-nancy.fr. 10. Lorraine University, INSERM, IADI, Nancy, France. a.verger@chru-nancy.fr.
Abstract
PURPOSE: 6-[18F]fluoro-L-DOPA ([18F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [18F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. PROCEDURES: One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [18F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p < 0.05 (corrected) and p < 0.005 (uncorrected, k cluster > 125). RESULTS: Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women). CONCLUSIONS: The uptake index of [18F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.
PURPOSE:6-[18F]fluoro-L-DOPA ([18F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [18F]FDOPA, expressed relative to the occipital background level, varies according to age and gender. PROCEDURES: One hundred and seventy-seven subjects were retrospectively included. A whole-brain statistical parametric mapping analysis of the [18F]FDOPA uptake index in parametric PET images was performed at a voxel threshold of p < 0.05 (corrected) and p < 0.005 (uncorrected, k cluster > 125). RESULTS: Striatal uptake indices were influenced by age, negatively for the caudate nucleus and positively for the putamen, as well as by gender, with a lower left putaminal uptake index in women. Extra-striatal uptake indices were influenced by age, negatively for the frontal cortex and brainstem and positively for the occipital cortex and cerebellum, as well as by gender (diffuse increase in women). CONCLUSIONS: The uptake index of [18F]FDOPA exhibited significant physiological variations according to age and gender and should therefore be considered for PET interpretation.
Entities:
Keywords:
Age; Gender; Quantitative analysis; Template; [18F]FDOPA PET
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