Literature DB >> 26321882

Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles.

Timothy E Morey1, Manoj Varshney1, Jason A Flint1, Surender Rajasekaran1, Dinesh O Shah1, Donn M Dennis1.   

Abstract

Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extracted bupivacaine from the aqueous phase in a physiological salt solution and attenuated the drug's cardiotoxicity in guinea pig heart to a greater extent than did a macroemulsion (432.0 nm). Additionally, nanoparticles sequestered bupivacaine from the aqueous phase of human blood and merit further investigation in animal models of intoxication.

Entities:  

Year:  2004        PMID： 26321882      PMCID： PMC4552340          DOI： 10.1021/nl049880w

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  9 in total

Review 1.  Nanotechnology in bio/clinical analysis.

Authors:  G Guetens; K Van Cauwenberghe; G De Boeck; R Maes; U R Tjaden; J van der Greef; M Highley; A T van Oosterom; E A de Bruijn
Journal:  J Chromatogr B Biomed Sci Appl       Date:  2000-02-28

2.  Nanostructures as tailored biological probes.

Authors:  T Andrew Taton
Journal:  Trends Biotechnol       Date:  2002-07       Impact factor: 19.536

Review 3.  Nanocapsule technology: a review.

Authors:  Patrick Couvreur; Gillian Barratt; Elias Fattal; Philippe Legrand; Christine Vauthier
Journal:  Crit Rev Ther Drug Carrier Syst       Date:  2002       Impact factor: 4.889

Review 4.  Molecular imaging, targeted therapeutics, and nanoscience.

Authors:  Samuel A Wickline; Gregory M Lanza
Journal:  J Cell Biochem Suppl       Date:  2002

5.  Mussel adhesive protein mimetic polymers for the preparation of nonfouling surfaces.

Authors:  Jeffrey L Dalsin; Bi-Huang Hu; Bruce P Lee; Phillip B Messersmith
Journal:  J Am Chem Soc       Date:  2003-04-09       Impact factor: 15.419

6.  Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats.

Authors:  G L Weinberg; T VadeBoncouer; G A Ramaraju; M F Garcia-Amaro; M J Cwik
Journal:  Anesthesiology       Date:  1998-04       Impact factor: 7.892

7.  Triglyceride-based microemulsion for intravenous administration of sparingly soluble substances.

Authors:  C von Corswant; P Thorén; S Engström
Journal:  J Pharm Sci       Date:  1998-02       Impact factor: 3.534

8.  Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity.

Authors:  Guy Weinberg; Richard Ripper; Douglas L Feinstein; William Hoffman
Journal:  Reg Anesth Pain Med       Date:  2003 May-Jun       Impact factor: 6.288

9.  Ionic basis of the differential effects of intravenous anesthetics on erythromycin-induced prolongation of ventricular repolarization in the guinea pig heart.

Authors:  T E Morey; A E Martynyuk; C A Napolitano; M J Raatikainen; T S Guyton; D M Dennis
Journal:  Anesthesiology       Date:  1997-11       Impact factor: 7.892
  9 in total
  9 in total

1.  A physiologically-based pharmacokinetic model of drug detoxification by nanoparticles.

Authors:  Marissa S Fallon; Manoj Varshney; Donn M Dennis; Anuj Chauhan
Journal:  J Pharmacokinet Pharmacodyn       Date:  2004-10       Impact factor: 2.745

2.  Scavenging nanoparticles: an emerging treatment for local anesthetic toxicity.

Authors:  Elizabeth M Renehan; F Kayser Enneking; Manoj Varshney; Richard Partch; Donn M Dennis; Timothy E Morey
Journal:  Reg Anesth Pain Med       Date:  2005 Jul-Aug       Impact factor: 6.288

3.  Anesthetic properties of a propofol microemulsion in dogs.

Authors:  Timothy E Morey; Jerome H Modell; Dushyant Shekhawat; Dinesh O Shah; Brian Klatt; George P Thomas; Frank A Kero; Matthew M Booth; Donn M Dennis
Journal:  Anesth Analg       Date:  2006-10       Impact factor: 5.108

Review 4.  Intravenous fat emulsion: a potential novel antidote.

Authors:  Danielle E Turner-Lawrence; William Kerns Ii
Journal:  J Med Toxicol       Date:  2008-06

5.  Preparation and anesthetic properties of propofol microemulsions in rats.

Authors:  Timothy E Morey; Jerome H Modell; Dushyant Shekhawat; Todd Grand; Dinesh O Shah; Nikolaus Gravenstein; Susan P McGorray; Donn M Dennis
Journal:  Anesthesiology       Date:  2006-06       Impact factor: 7.892

6.  Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels.

Authors:  Todd Hoare; Daryl Sivakumaran; Cristina F Stefanescu; Michael W Lawlor; Daniel S Kohane
Journal:  Acta Biomater       Date:  2011-12-29       Impact factor: 8.947

Review 7.  From micro- to nanostructured implantable device for local anesthetic delivery.

Authors:  Laura Zorzetto; Paola Brambilla; Elena Marcello; Nora Bloise; Manuela De Gregori; Lorenzo Cobianchi; Andrea Peloso; Massimo Allegri; Livia Visai; Paola Petrini
Journal:  Int J Nanomedicine       Date:  2016-06-08

8.  Effects of Acidification and Alkalinization on the Lipid Emulsion-Mediated Reversal of Toxic Dose Levobupivacaine-Induced Vasodilation in the Isolated Rat Aorta.

Authors:  Seong-Ho Ok; Won Ho Kim; Jongsun Yu; Youngju Lee; Mun-Jeoung Choi; Dong Hoon Lim; Yeran Hwang; Yeon A Kim; Ju-Tae Sohn
Journal:  Int J Med Sci       Date:  2016-01-25       Impact factor: 3.738

9.  Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta.

Authors:  Seong-Ho Ok; Jeong Yeol Han; Soo Hee Lee; Il-Woo Shin; Heon Keun Lee; Young-Kyun Chung; Mun-Jeoung Choi; Ju-Tae Sohn
Journal:  Korean J Anesthesiol       Date:  2013-04-22
  9 in total

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