Literature DB >> 26319887

Anastomotic leak in colorectal surgery: are 75 % preventable?

Hodjat Shekarriz1, Janina Eigenwald2, Bijan Shekarriz3, Jyoti Upadhyay4, Jasmin Shekarriz2, Danny Zoubie2, Thilo Wedel5, Henning Wittenburg2.   

Abstract

INTRODUCTION: Anastomotic leak (AL) is a significant cause of morbidity and mortality associated with complications of colorectal surgery. Furthermore, AL results in prolonged hospital stays and significant increase in costs of medical resources.
MATERIALS AND METHODS: In this study, we investigated the impact of anastomosis technique on the rate of anastomotic leak. The rate of leak was compared between two groups performing end-to-end (E-E) vs. side-to-end (S-E) anastomosis. The impact of various risk factors was also compared between the two groups.
RESULTS: There were 382 E-E and 363 S-E anastomoses after left colectomy or rectal resections. The anastomotic leak rate was 8.64 % using E-E compared to 1.93 % using S-E anastomosis technique (p < 0.001).
CONCLUSIONS: These results indicate that the rate of anastomotic leak after left colon and rectum resections could be significantly reduced utilizing S-E anastomosis technique.

Entities:  

Keywords:  Anastomosis technique; Anastomotic leak; Colorectal surgery; End-to-end anastomosis; Side-to-end anastomosis

Mesh:

Year:  2015        PMID: 26319887     DOI: 10.1007/s00384-015-2338-z

Source DB:  PubMed          Journal:  Int J Colorectal Dis        ISSN: 0179-1958            Impact factor:   2.571


  30 in total

Review 1.  [Endoscopic therapy for leaks in the gastrointestinal tract, the bile ducts and the pancreas].

Authors:  M Wettstein; T Frieling; R Lüthen; T Heintges; C Niederau; M Oette; C Vogt; S Vom Dahl
Journal:  Z Gastroenterol       Date:  2011-06-01       Impact factor: 2.000

2.  Recurrence of Crohn's disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial.

Authors:  Robin S McLeod; Bruce G Wolff; Sue Ross; Robert Parkes; Margaret McKenzie
Journal:  Dis Colon Rectum       Date:  2009-05       Impact factor: 4.585

3.  Incidence of and risk factors for anastomotic leakage after laparoscopic anterior resection with intracorporeal rectal transection and double-stapling technique anastomosis for rectal cancer.

Authors:  Takashi Akiyoshi; Masashi Ueno; Yosuke Fukunaga; Satoshi Nagayama; Yoshiya Fujimoto; Tsuyoshi Konishi; Hiroya Kuroyanagi; Toshiharu Yamaguchi
Journal:  Am J Surg       Date:  2011-09       Impact factor: 2.565

4.  Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision.

Authors:  W I Law; K W Chu; J W Ho; C W Chan
Journal:  Am J Surg       Date:  2000-02       Impact factor: 2.565

5.  [The effect of systemic and local irradiation on wound macrophages and the repair promoting action of phenytoin sodium].

Authors:  S Song; T Cheng
Journal:  Zhonghua Yi Xue Za Zhi       Date:  1997-01

6.  Assessment of gastrointestinal blood flow with laser Doppler flowmetry in patients with chronic radiation injury.

Authors:  K Johansson; H Ahn; A Herder; J Lindhagen
Journal:  Acta Chir Scand       Date:  1988-04

7.  Risk factors for anastomotic leakage after preoperative chemoradiation therapy and low anterior resection with total mesorectal excision for locally advanced rectal cancer.

Authors:  Saúl E Rodríguez-Ramírez; Arizbeth Uribe; Erika Betzabé Ruiz-García; Sonia Labastida; Pedro Luna-Pérez
Journal:  Rev Invest Clin       Date:  2006 May-Jun       Impact factor: 1.451

8.  Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery.

Authors:  L T Sørensen; T Jørgensen; L T Kirkeby; J Skovdal; B Vennits; P Wille-Jørgensen
Journal:  Br J Surg       Date:  1999-07       Impact factor: 6.939

9.  Healing of experimental colonic anastomoses: effects of combined preoperative high-dose radiotherapy and intraperitoneal 5-fluorouracil.

Authors:  M El-Malt; W Ceelen; C van den Broecke; C Cuvelier; S Van Belle; W De Neve; B de Hemptinne; P Pattyn
Journal:  Int J Cancer       Date:  2001-10-20       Impact factor: 7.396

10.  Moderate doses of intraoperative radiation severely suppress early strength of anastomoses in the rat colon.

Authors:  T Hendriks; T Wobbes; B M de Man; J Hoogenhout; W F Seifert
Journal:  Radiat Res       Date:  1998-10       Impact factor: 2.841

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  2 in total

1.  Changes in Clinical Practice Reduce the Rate of Anastomotic Leakage After Colorectal Resections.

Authors:  Henrik Iversen; Madelene Ahlberg; Marja Lindqvist; Christian Buchli
Journal:  World J Surg       Date:  2018-07       Impact factor: 3.352

2.  Adipose-Derived Mesenchymal Stromal Cells Improve the Healing of Colonic Anastomoses Following High Dose of Irradiation Through Anti-Inflammatory and Angiogenic Processes.

Authors:  Dirk Van de Putte; Christelle Demarquay; Elke Van Daele; Lara Moussa; Christian Vanhove; Marc Benderitter; Wim Ceelen; Piet Pattyn; Noëlle Mathieu
Journal:  Cell Transplant       Date:  2017-12       Impact factor: 4.064

  2 in total

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