Literature DB >> 21586362

Impact of ectoenzymes on p2 and p1 receptor signaling.

Filip Kukulski1, Sébastien A Lévesque, Jean Sévigny.   

Abstract

P2 receptors that are activated by extracellular nucleotides (e.g., ATP, ADP, UTP, UDP, Ap(n)A) and P1 receptors activated by adenosine control a diversity of biological processes. The activation of these receptors is tightly regulated by ectoenzymes that metabolize their ligands. This review presents these enzymes as well as their roles in the regulation of P2 and P1 receptor activation. We focus specifically on the role of ectoenzymes in processes of our interest, that is, inflammation, vascular tone, and neurotransmission. An update on the development of ectonucleotidase inhibitors is also presented.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21586362     DOI： 10.1016/B978-0-12-385526-8.00009-6

Source DB:  PubMed          Journal:  Adv Pharmacol        ISSN： 1054-3589


  62 in total

Review 1.  G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions.

Authors:  Kenneth A Jacobson; Ramachandran Balasubramanian; Francesca Deflorian; Zhan-Guo Gao
Journal:  Purinergic Signal       Date:  2012-02-29       Impact factor: 3.765

Review 2.  The role of P2X7 receptors in tissue fibrosis: a brief review.

Authors:  Daniela Gentile; Mariarita Natale; Pietro Enea Lazzerini; Pier Leopoldo Capecchi; Franco Laghi-Pasini
Journal:  Purinergic Signal       Date:  2015-08-29       Impact factor: 3.765

3.  Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1).

Authors:  Yue Zhang; Simon C Robson; Kaiya L Morris; Kristina M Heiney; Karen M Dwyer; Bellamkonda K Kishore; Carolyn M Ecelbarger
Journal:  Am J Physiol Renal Physiol       Date:  2015-04-15

Review 4.  Nucleotides Acting at P2Y Receptors: Connecting Structure and Function.

Authors:  Kenneth A Jacobson; Silvia Paoletta; Vsevolod Katritch; Beili Wu; Zhan-Guo Gao; Qiang Zhao; Raymond C Stevens; Evgeny Kiselev
Journal:  Mol Pharmacol       Date:  2015-04-02       Impact factor: 4.436

Review 5.  Conversion of extracellular ATP into adenosine: a master switch in renal health and disease.

Authors:  Karen M Dwyer; Bellamkonda K Kishore; Simon C Robson
Journal:  Nat Rev Nephrol       Date:  2020-07-08       Impact factor: 28.314

Review 6.  Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD.

Authors:  Mathias Haarhaus; Vincent Brandenburg; Kamyar Kalantar-Zadeh; Peter Stenvinkel; Per Magnusson
Journal:  Nat Rev Nephrol       Date:  2017-05-15       Impact factor: 28.314

Review 7.  Inflammation, pain, and pressure--purinergic signaling in oral tissues.

Authors:  J C Lim; C H Mitchell
Journal:  J Dent Res       Date:  2012-10-04       Impact factor: 6.116

8.  Adenosine arrests breast cancer cell motility by A3 receptor stimulation.

Authors:  Carola Ledderose; Marco M Hefti; Yu Chen; Yi Bao; Thomas Seier; Linglin Li; Tobias Woehrle; Jingping Zhang; Wolfgang G Junger
Journal:  Purinergic Signal       Date:  2016-08-30       Impact factor: 3.765

9.  Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium.

Authors:  Elisabet Aliagas; August Vidal; Benjamín Torrejón-Escribano; Maria del Rosario Taco; Jordi Ponce; Inmaculada Gómez de Aranda; Jean Sévigny; Enric Condom; Mireia Martín-Satué
Journal:  Purinergic Signal       Date:  2012-12-06       Impact factor: 3.765

10.  8-BuS-ATP derivatives as specific NTPDase1 inhibitors.

Authors:  Joanna Lecka; Irina Gillerman; Michel Fausther; Mabrouka Salem; Mercedes N Munkonda; Jean-Philippe Brosseau; Christine Cadot; Mireia Martín-Satué; Pedro d'Orléans-Juste; Eric Rousseau; Donald Poirier; Beat Künzli; Bilha Fischer; Jean Sévigny
Journal:  Br J Pharmacol       Date:  2013-05       Impact factor: 8.739
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