Literature DB >> 26317460

DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.

Jonathan D Licht1.   

Abstract

DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequences.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26317460     DOI： 10.1016/j.cell.2015.08.005

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  27 in total

1.  Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia.

Authors:  Jens Przybilla; Lydia Hopp; Michael Lübbert; Markus Loeffler; Joerg Galle
Journal:  Epigenetics       Date:  2017-10-06       Impact factor: 4.528

2.  The development and validation of EpiComet-Chip, a modified high-throughput comet assay for the assessment of DNA methylation status.

Authors:  Todd A Townsend; Marcus C Parrish; Bevin P Engelward; Mugimane G Manjanatha
Journal:  Environ Mol Mutagen       Date:  2017-07-29       Impact factor: 3.216

3.  Hypomethylation reduced the aggressive potential of human malignant mesothelioma cells.

Authors:  N-Y Kim; M-C Kim; Y Kim
Journal:  Cancer Gene Ther       Date:  2016-11-18       Impact factor: 5.987

4.  Effective demethylation of melanoma cells using terahertz radiation.

Authors:  Hwayeong Cheon; Hee-Jin Yang; Moran Choi; Joo-Hiuk Son
Journal:  Biomed Opt Express       Date:  2019-09-05       Impact factor: 3.732

Review 5.  Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications.

Authors:  Tathiane M Malta; Camila F de Souza; Thais S Sabedot; Tiago C Silva; Maritza S Mosella; Steven N Kalkanis; James Snyder; Ana Valeria B Castro; Houtan Noushmehr
Journal:  Neuro Oncol       Date:  2018-04-09       Impact factor: 12.300

6.  Activation of lnc-ALVE1-AS1 inhibited ALV-J replication through triggering the TLR3 pathway in chicken macrophage like cell line.

Authors:  Huan Luo; Xuming Hu; Huixian Wu; Gul Zaib; Wenxian Chai; Hengmi Cui
Journal:  Vet Res Commun       Date:  2022-06-17       Impact factor: 2.459

7.  A systematic pan-cancer analysis identifies RIOK3 as an immunological and prognostic biomarker.

Authors:  Jian Li; Ruili Sun; Lixiang He; Guoyi Sui; Wenyu Di; Jian Yu; Wei Su; Zenggang Pan; Yu Zhang; Jinghang Zhang; Feng Ren
Journal:  Am J Transl Res       Date:  2022-06-15       Impact factor: 3.940

Review 8.  Differentiation therapy revisited.

Authors:  Hugues de Thé
Journal:  Nat Rev Cancer       Date:  2017-12-01       Impact factor: 60.716

9.  Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences.

Authors:  Ken Declerck; Claudina Perez Novo; Lisa Grielens; Guy Van Camp; Andreas Suter; Wim Vanden Berghe
Journal:  BMC Complement Med Ther       Date:  2021-05-12

10.  Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents.

Authors:  Jane Merlevede; Nathalie Droin; Tingting Qin; Kristen Meldi; Kenichi Yoshida; Margot Morabito; Emilie Chautard; Didier Auboeuf; Pierre Fenaux; Thorsten Braun; Raphael Itzykson; Stéphane de Botton; Bruno Quesnel; Thérèse Commes; Eric Jourdan; William Vainchenker; Olivier Bernard; Noemie Pata-Merci; Stéphanie Solier; Velimir Gayevskiy; Marcel E Dinger; Mark J Cowley; Dorothée Selimoglu-Buet; Vincent Meyer; François Artiguenave; Jean-François Deleuze; Claude Preudhomme; Michael R Stratton; Ludmil B Alexandrov; Eric Padron; Seishi Ogawa; Serge Koscielny; Maria Figueroa; Eric Solary
Journal:  Nat Commun       Date:  2016-02-24       Impact factor: 14.919
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