Miao-Shang Su1,2, Hai-Lin Zhang3,4, Xiao-Hong Cai5, Ying Lin6, Pei-Ning Liu7,8, Yuan-Bo Zhang9, Wen-Zhen Hu10, Chang-Chong Li11, Yan-Feng Xiao12. 1. Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi Province, People's Republic of China. sumish@wzhealth.com. 2. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. sumish@wzhealth.com. 3. Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi Province, People's Republic of China. zhlwz97@hotmail.com. 4. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. zhlwz97@hotmail.com. 5. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. caixh839@sina.com. 6. Department of Public Health, Center for Disease Control and Prevention in Wenzhou, Zhejiang, People's Republic of China. linying889216@163.com. 7. Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi Province, People's Republic of China. liupeining366@sina.com. 8. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. liupeining366@sina.com. 9. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. zybhuake@163.com. 10. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. huwenzhen1227@163.com. 11. Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China. wzlichch@21cn.com. 12. Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi Province, People's Republic of China. xiaoyanfeng_xjtu@sina.com.
Abstract
This study investigated the association between obesity and obstructive sleep apnea (OSA) in preschool and school-age children. Parents of obese and randomly chosen normal weight children completed a questionnaire on sleep-related symptoms, demography, family, and medical history. All subjects were invited to undergo polysomnography (PSG). OSA cases were defined as obstructive apnea hypopnea index (OAHI) ≥1. A total of 5930 children were studied with 9.5% obese (11.9% boys/6.1% girls), 205/2680 preschool and 360/3250 school children. There were 1030 children (535 obese/495 normal weight) who underwent PSG. OSA was higher in obese children and obese school children had higher OAHI, arousal index, and shorter total sleep time. However, there was no positive correlation between OSA and body mass index (BMI). The main risk factors for OSA in preschool children were adenotonsillar hypertrophy and recurrent respiratory tract infection. The main cause for OSA in school children was a history of parental snoring and obesity. Mallampati scores and sleep-related symptoms were found to be associated with OSA in both preschool and school children. CONCLUSION: We demonstrated differential risk factors for OSA in obese children, which suggest that a different mechanism may be involved in OSA development in preschool and school-age children. WHAT IS KNOWN: Various risk factors have been reported in obese children with OSA owing to the different age and different study design. Obese children have a higher prevalence and severity of obstructive sleep apnea (OSA). OSA risk factors in obese children are affected by different ages and study designs. WHAT IS NEW: A differential prevalence and risk factors for obese preschool and school-age children with OSA has been demonstrated.
This study investigated the association between obesity and obstructive sleep apnea (OSA) in preschool and school-age children. Parents of obese and randomly chosen normal weight children completed a questionnaire on sleep-related symptoms, demography, family, and medical history. All subjects were invited to undergo polysomnography (PSG). OSA cases were defined as obstructive apnea hypopnea index (OAHI) ≥1. A total of 5930 children were studied with 9.5% obese (11.9% boys/6.1% girls), 205/2680 preschool and 360/3250 school children. There were 1030 children (535 obese/495 normal weight) who underwent PSG. OSA was higher in obese children and obese school children had higher OAHI, arousal index, and shorter total sleep time. However, there was no positive correlation between OSA and body mass index (BMI). The main risk factors for OSA in preschool children were adenotonsillar hypertrophy and recurrent respiratory tract infection. The main cause for OSA in school children was a history of parental snoring and obesity. Mallampati scores and sleep-related symptoms were found to be associated with OSA in both preschool and school children. CONCLUSION: We demonstrated differential risk factors for OSA in obese children, which suggest that a different mechanism may be involved in OSA development in preschool and school-age children. WHAT IS KNOWN: Various risk factors have been reported in obese children with OSA owing to the different age and different study design. Obese children have a higher prevalence and severity of obstructive sleep apnea (OSA). OSA risk factors in obese children are affected by different ages and study designs. WHAT IS NEW: A differential prevalence and risk factors for obese preschool and school-age children with OSA has been demonstrated.
Authors: Maria J Gutierrez; Gustavo Nino; Jeremy S Landeo-Gutierrez; Miriam R Weiss; Diego A Preciado; Xiumei Hong; Xiaobin Wang Journal: Sleep Date: 2021-12-10 Impact factor: 6.313
Authors: Zhen Zheng; Li Zhang; Shiping Li; Fengyan Zhao; Yan Wang; Lan Huang; Jinglan Huang; Rong Zou; Yi Qu; Dezhi Mu Journal: Sci Rep Date: 2017-09-15 Impact factor: 4.379