Marina Medeiros1, Andréa C Matos2, Silvia E Pereira2,3, Carlos Saboya2,3, Andréa Ramalho4. 1. Center for Research On Micronutrients, Josué de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373. Edifício dos Institutos, Bloco J, 2° andar, Ilha do Fundão, Rio de Janeiro, CEP: 21941-590, RJ, Brazil. marimd89@hotmail.com. 2. Center for Research On Micronutrients, Josué de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373. Edifício dos Institutos, Bloco J, 2° andar, Ilha do Fundão, Rio de Janeiro, CEP: 21941-590, RJ, Brazil. 3. Clínica Cirúrgica Carlos Saboya, Rio de Janeiro, RJ, Brazil. 4. Center for Research On Micronutrients, Josué de Castro Institute of Nutrition, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373. Edifício dos Institutos, Bloco J, 2° andar, Ilha do Fundão, Rio de Janeiro, CEP: 21941-590, RJ, Brazil. aramalho.rj@gmail.com.
Abstract
PURPOSE: The objective of this study was to evaluate vitamin D nutritional status and its relation with ionic calcium, parathyroid hormone (PTH), maternal anthropometry and perinatal outcomes in pregnant women who previously underwent Roux-en-Y gastric bypass (RYGB) surgery. METHODS: In a clinic specialized in obesity control located in the city of Rio de Janeiro (Brazil), the following information were collected for adult women who underwent RYGB before pregnancy: serum concentrations of vitamin D [25(OH)D], calcium and PTH per gestational trimester and data on maternal anthropometry, gestational intercurrences and perinatal outcomes. RESULTS: The present study included 46 post-RYGB pregnant women. The prevalence of pregnant women with deficiency (≤20 ng/mL) or insufficiency (≥21 and 29 ng/mL) of vitamin D was above 70% in all trimesters. The prevalence of calcium deficiency was 15.2% in the first and in the second trimesters and 20% in the third trimester, while the prevalence of excess PTH was 19.6, 30.4 and 32.6% in the first, the second and the third trimesters, respectively. In the second and the third trimesters, a significant difference was observed between concentrations of 25(OH)D, and a negative correlation was observed between concentrations of calcium and PTH. Association of 25(OH)D with urinary tract infection (UTI) was found, but there was no association with calcium, PTH, maternal anthropometry, type of delivery and weight and gestational age at birth CONCLUSIONS: The post-RYGB pregnant women showed an elevated serum inadequacy (deficiency or insufficiency) of 25(OH)D during pregnancy. Maternal vitamin D status showed no association with maternal variables, except UTI, and the neonatal variables analyzed.
PURPOSE: The objective of this study was to evaluate vitamin D nutritional status and its relation with ionic calcium, parathyroid hormone (PTH), maternal anthropometry and perinatal outcomes in pregnant women who previously underwent Roux-en-Y gastric bypass (RYGB) surgery. METHODS: In a clinic specialized in obesity control located in the city of Rio de Janeiro (Brazil), the following information were collected for adult women who underwent RYGB before pregnancy: serum concentrations of vitamin D [25(OH)D], calcium and PTH per gestational trimester and data on maternal anthropometry, gestational intercurrences and perinatal outcomes. RESULTS: The present study included 46 post-RYGB pregnant women. The prevalence of pregnant women with deficiency (≤20 ng/mL) or insufficiency (≥21 and 29 ng/mL) of vitamin D was above 70% in all trimesters. The prevalence of calciumdeficiency was 15.2% in the first and in the second trimesters and 20% in the third trimester, while the prevalence of excess PTH was 19.6, 30.4 and 32.6% in the first, the second and the third trimesters, respectively. In the second and the third trimesters, a significant difference was observed between concentrations of 25(OH)D, and a negative correlation was observed between concentrations of calcium and PTH. Association of 25(OH)D with urinary tract infection (UTI) was found, but there was no association with calcium, PTH, maternal anthropometry, type of delivery and weight and gestational age at birth CONCLUSIONS: The post-RYGB pregnant women showed an elevated serum inadequacy (deficiency or insufficiency) of 25(OH)D during pregnancy. Maternal vitamin D status showed no association with maternal variables, except UTI, and the neonatal variables analyzed.
Authors: Jürgen Harreiter; Karin Schindler; Dagmar Bancher-Todesca; Christian Göbl; Felix Langer; Gerhard Prager; Alois Gessl; Michael Leutner; Bernhard Ludvik; Anton Luger; Alexandra Kautzky-Willer; Michael Krebs Journal: J Obes Date: 2018-06-03
Authors: Katinka M Snoek; Régine P M Steegers-Theunissen; Eric J Hazebroek; Sten P Willemsen; Sander Galjaard; Joop S E Laven; Sam Schoenmakers Journal: Hum Reprod Update Date: 2021-10-18 Impact factor: 15.610