Montserrat Martínez-Alonso1, Adriana Dusso2, Gemma Ariza3, Maria Nabal4. 1. Unit of Biostatistics and Methodological Support, IRBLLEIDA, Lleida, Spain montserrat.martinez@cmb.udl.cat. 2. Division of Experimental Nephrology, IRBLLEIDA, Lleida, Spain Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. 3. Rehabilitation Unit, Hospital Universitari Arnau de Vilanova de Lleida, Lleida, Spain. 4. Palliative Care Supportive Team, Hospital Universitari Arnau de Vilanova de Lleida, Lleida, Spain.
Abstract
BACKGROUND: A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body. AIM: To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancer patients. DESIGN: This is a cross-sectional study. PATIENTS/SETTINGS: Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer. RESULTS: Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue (s = 0.49), and physical and functional well-being (s = 0.44 and s = 0.41, respectively, p < 0.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D (p = 0.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status. CONCLUSION: The 90% frequency of advanced cancer patients with vitamin D deficiency, together with the positive correlation of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient's quality of life.
BACKGROUND: A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body. AIM: To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancerpatients. DESIGN: This is a cross-sectional study. PATIENTS/SETTINGS: Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer. RESULTS: Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue (s = 0.49), and physical and functional well-being (s = 0.44 and s = 0.41, respectively, p < 0.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D (p = 0.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status. CONCLUSION: The 90% frequency of advanced cancerpatients with vitamin D deficiency, together with the positive correlation of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient's quality of life.
Authors: Jorge B Cannata-Andía; Augusto Díaz-Sottolano; Pehuén Fernández; Manuel Naves-Díaz; Walter Douthat; José L Fernández-Martín; Carmen Palomo-Antequera; Pablo Herrero-Puente; Ricardo Mouzo; Natalia Carrillo-López; Sara Panizo; Guillermo H Ibañez; Carlos A Cusumano; Carolina Ballarino; Vicente Sánchez-Polo; Jacqueline Pefaur-Penna; Irene Maderuelo-Riesco; Jesús Calviño-Varela; Mónica D Gómez; Carlos Gómez-Alonso; John Cunningham Journal: BMC Med Date: 2022-02-18 Impact factor: 8.775
Authors: Ben Schöttker; Sabine Kuznia; Dana Clarissa Laetsch; David Czock; Annette Kopp-Schneider; Reiner Caspari; Hermann Brenner Journal: BMC Cancer Date: 2020-08-08 Impact factor: 4.430