| Literature DB >> 26315392 |
Xueshun Wang1, Boshi Huang1, Xinyong Liu2, Peng Zhan3.
Abstract
The rapid assembly and in situ screening of focused combinatorial fragment libraries using CuAAC click chemistry is a highly robust and efficient strategy for establishing SAR and for discovering bioactive molecules. This review outlines the current status of this methodology in drug discovery application. The inherent limitations, challenges and prospects are critically discussed.Entities:
Mesh：
Year: 2015 PMID： 26315392 DOI： 10.1016/j.drudis.2015.08.004
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851