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Literature DB >> 26314800

Single cell nanobiosensors for dynamic gene expression profiling in native tissue microenvironments.

Shue Wang¹, Reza Riahi², Na Li³, Donna D Zhang⁴, Pak Kin Wong^1,5.

Abstract

A gold nanorod-locked nucleic acid nano-biosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.

Entities: Species

Keywords: biosensors; locked nucleic acids; nanoparticles; single cells; tissue microenvironments

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Substances：

Year: 2015 PMID： 26314800 DOI： 10.1002/adma.201502814

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

14 in total

Review 1. Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes.

Authors: Yuqiong Xia; Ruili Zhang; Zhongliang Wang; Jie Tian; Xiaoyuan Chen
Journal: Chem Soc Rev Date: 2017-05-22 Impact factor: 54.564

2. Notch signaling in regulating angiogenesis in a 3D biomimetic environment.

Authors: Yi Zheng; Shue Wang; Xufeng Xue; Alan Xu; Wei Liao; Alice Deng; Guohao Dai; Allen P Liu; Jianping Fu
Journal: Lab Chip Date: 2017-05-31 Impact factor: 6.799

Review 3. Nucleic-Acid Structures as Intracellular Probes for Live Cells.

Authors: Devleena Samanta; Sasha B Ebrahimi; Chad A Mirkin
Journal: Adv Mater Date: 2019-07-04 Impact factor: 30.849

4. Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy.

Authors: Kristine M Mayle; Kathryn R Dern; Vincent K Wong; Kevin Y Chen; Shijun Sung; Ke Ding; April R Rodriguez; Scott Knowles; Zachary Taylor; Z Hong Zhou; Warren S Grundfest; Anna M Wu; Timothy J Deming; Daniel T Kamei
Journal: SLAS Technol Date: 2016-09-26 Impact factor: 3.047

10. Simultaneous monitoring of transcription and translation in mammalian cell-free expression in bulk and in cell-sized droplets.

Authors: Shue Wang; Sagardip Majumder; Nicholas J Emery; Allen P Liu
Journal: Synth Biol (Oxf) Date: 2018-05-21

Single cell nanobiosensors for dynamic gene expression profiling in native tissue microenvironments.

Review 1. Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes.

2. Notch signaling in regulating angiogenesis in a 3D biomimetic environment.

Review 3. Nucleic-Acid Structures as Intracellular Probes for Live Cells.

4. Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy.

5. Polypeptide-Based Gold Nanoshells for Photothermal Therapy.

6. A nanobiosensor for dynamic single cell analysis during microvascular self-organization.

7. A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells.

8. Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling.

9. Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications.

10. Simultaneous monitoring of transcription and translation in mammalian cell-free expression in bulk and in cell-sized droplets.