Literature DB >> 26314672

Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer.

Takahiro Shimizu1, Hiroyuki Marusawa1, Norihiko Watanabe1, Tsutomu Chiba2.   

Abstract

Helicobacter pylori infection plays a crucial role in gastric carcinogenesis. H pylori exerts oncogenic effects on gastric mucosa through complex interaction between bacterial virulence factors and host inflammatory responses. On the other hand, gastric cancer develops via stepwise accumulation of genetic and epigenetic alterations in H pylori-infected gastric mucosa. Recent comprehensive analyses of gastric cancer genomes indicate a multistep process of genetic alterations as well as possible molecular mechanisms of gastric carcinogenesis. Both genetic processes of gastric cancer development and molecular oncogenic pathways related to H pylori infection are important to completely understand the pathogenesis of H pylori-related gastric cancer.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Epigenetics; Gastric cancer; Genetics; Helicobacter pylori; Inflammation

Mesh：

Substances：

Year:  2015        PMID： 26314672     DOI： 10.1016/j.gtc.2015.05.011

Source DB:  PubMed          Journal:  Gastroenterol Clin North Am        ISSN： 0889-8553            Impact factor:   3.806


  7 in total

1.  Gastrointestinal Factor GDDR Attenuates Epithelial-Mesenchymal Transition in Gastric Cancer via Inhibiting AKT Signal.

Authors:  Cheng Fang; Ziqiang Zhang; Chaoxu Liu; Gang Wang; Fei Wang; Zhanwei Zhao; Wenhui Li; Jin Hua; Jianbo Shuang; Jianjun Du
Journal:  Dig Dis Sci       Date:  2016-03-26       Impact factor: 3.199

Review 2.  Molecular mechanism of Helicobacter pylori-induced autophagy in gastric cancer.

Authors:  Fan Zhang; Cong Chen; Jike Hu; Ruiliang Su; Junqiang Zhang; Zhijian Han; Hao Chen; Yumin Li
Journal:  Oncol Lett       Date:  2019-10-10       Impact factor: 2.967

3.  E-Cadherin Protein as a Potential Marker for Gastric Cancer and Its Association with Helicobacter Pylori- Induced Gastritis and Gastric Ulcer.

Authors:  Mustafa Kahtan Al-Bayaty; Salma Abdul-Rudha Abass; Mohammed Faraj Al-Marjani
Journal:  Rep Biochem Mol Biol       Date:  2019-10

Review 4.  Pleiotropic cytotoxicity of VacA toxin in host cells and its impact on immunotherapy.

Authors:  Farnaz Fahimi; Mohammad Reza Tohidkia; Mehdi Fouladi; Reza Aghabeygi; Naser Samadi; Yadollah Omidi
Journal:  Bioimpacts       Date:  2017-03-30

5.  Analysis of risks of gastric cancer by gastric mucosa among Indonesian ethnic groups.

Authors:  Muhammad Miftahussurur; Langgeng Agung Waskito; Ari Fahrial Syam; Iswan Abbas Nusi; I Dewa Nyoman Wibawa; Yudith Annisa Ayu Rezkitha; Gontar Siregar; O K Yulizal; Fardah Akil; Willy Brodus Uwan; David Simanjuntak; Jimmy Bradley Waleleng; Alexander Michael Joseph Saudale; Fauzi Yusuf; Hasan Maulahela; Marselino Richardo; Abdul Rahman; Yoma Sari Namara; Eko Sudarmo; Pangestu Adi; Ummi Maimunah; Poernomo Boedi Setiawan; Kartika Afrida Fauzia; Dalla Doohan; Tomohisa Uchida; Maria Inge Lusida; Yoshio Yamaoka
Journal:  PLoS One       Date:  2019-05-09       Impact factor: 3.240

Review 6.  Pharmacological activities and mechanisms of action of Pogostemon cablin Benth: a review.

Authors:  Chen Junren; Xie Xiaofang; Li Mengting; Xiong Qiuyun; Li Gangmin; Zhang Huiqiong; Chen Guanru; Xu Xin; Yin Yanpeng; Peng Fu; Peng Cheng
Journal:  Chin Med       Date:  2021-01-07       Impact factor: 5.455

Review 7.  Role of polymorphisms in genes that encode cytokines and Helicobacter pylori virulence factors in gastric carcinogenesis.

Authors:  Breno Bittencourt de Brito; Filipe Antônio França da Silva; Fabrício Freire de Melo
Journal:  World J Clin Oncol       Date:  2018-09-14
  7 in total

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