Young Ho Lee1, Sang-Cheol Bae2, Gwan Gyu Song1. 1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. 2. The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea.
Abstract
OBJECTIVES: The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA). METHODS: We conducted a meta-analysis on the association between FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1/NA2 polymorphisms and RA susceptibility. RESULTS: A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared toFF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis. CONCLUSIONS: Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated with RA in Europeans, but not in Asians.
OBJECTIVES: The aim of this study is to explore whether Fc gamma receptor (FCGR) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA). METHODS: We conducted a meta-analysis on the association between FCGR2AH131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1/NA2 polymorphisms and RA susceptibility. RESULTS: A total of seventeen studies reported in fourteen articles (4,418 patients with RA and 3,560 controls) were considered in our meta-analysis. In all of the study subjects, meta-analysis indicated an association between RA and FCGR2A R allele (OR=0.877, 95% CI=0.792-0.971, p=0.011). Stratification by ethnicity indicated an association between FCGR2A R allele and RA in Europeans (OR=0.816, 95% CI=0.687-0.968, p=0.020), but not in East Asians (OR=0.900, 95% CI=0.778-1.040, p=0.154). Meta-analysis revealed an association between RA and FCGR3A VV vs. FF genotype in all the study subjects (OR=1.210, 95% CI=1.067-1.479, p=0.006). Stratification by ethnicity indicated an association between FCGR3A VV genotype and RA compared toFF genotype in Europeans (OR=1.350, 95% CI=1.107-1.646, p=0.003), but not in East Asians and South Asians. No association was observed between RA and FCGR3B polymorphisms on performing the meta-analysis. CONCLUSIONS: Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated with RA in Europeans, but not in Asians.
Authors: Jonathan J Hubbard; Michal Pyzik; Timo Rath; Lisa K Kozicky; Kine M K Sand; Amit K Gandhi; Algirdas Grevys; Stian Foss; Susan C Menzies; Jonathan N Glickman; Edda Fiebiger; Derry C Roopenian; Inger Sandlie; Jan Terje Andersen; Laura M Sly; Kristi Baker; Richard S Blumberg Journal: J Exp Med Date: 2020-10-05 Impact factor: 14.307
Authors: Carlos de la Calle-Fabregat; Javier Rodríguez-Ubreva; Laura Ciudad; Julio Ramírez; Raquel Celis; Ana Belén Azuaga; Andrea Cuervo; Eduard Graell; Carolina Pérez-García; César Díaz-Torné; Georgina Salvador; José A Gómez-Puerta; Isabel Haro; Raimon Sanmartí; Juan D Cañete; Esteban Ballestar Journal: JCI Insight Date: 2022-05-09