Sarah Chantler1, Kasha Dickie1, Lisa K Micklesfield1,2, Julia H Goedecke1,3. 1. 1 Division for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town , Cape Town, South Africa . 2. 2 South African Medical Research Council/University of the Witwatersrand Developmental Pathways for Health Research Unit, Department of Pediatrics, Faculty of Health Sciences, University of Witwatersrand , Johannesburg, South Africa . 3. 3 Non-Communicable Disease Research Unit, South African Medical Research Council , Parow, South Africa .
Abstract
BACKGROUND: Ethnic differences in body composition and cardiometabolic risk have been reported in cross-sectional studies. This study aimed to investigate changes in body composition over 5.5 years, and its association with cardiometabolic risk in premenopausal black South African (SA) women. METHODS: Changes in body composition and body fat distribution (dual-energy x-ray absorptiometry and computerized tomography), fasting glucose, insulin, and lipid concentrations, were measured in 63 black SA women at baseline (age: 27 ± 8 years), and 5.5 years later. RESULTS: Body weight and fat mass (FM) increased by 6.9 ± 9.9 kg and 4.3 ± 6.9 kg, respectively, over the 5.5 years with a relative (%FM) increase in central and decrease in peripheral FM (all P < 0.05). Fasting glucose and lipid concentrations (except HDL-cholesterol) increased over the follow-up period (all P < 0.05). Both baseline and changes in body fat distribution were associated with cardiometabolic risk. Independent of baseline age, FM and insulin sensitivity, baseline trunk:leg was associated with reduced insulin sensitivity at follow-up (Matsuda index; β = -0.41, P = 0.002). Increasing trunk:gynoid ratio was associated with higher plasma insulin levels (β = 0.31, P = 0.023) and reduced insulin sensitivity (Matsuda index; β = -0.52, P < 0.001) at follow-up. CONCLUSIONS: Weight gain in free-living black SA women over 5.5 years was associated with a centralization of fat mass, which predicted an increase in cardiometabolic risk.
BACKGROUND: Ethnic differences in body composition and cardiometabolic risk have been reported in cross-sectional studies. This study aimed to investigate changes in body composition over 5.5 years, and its association with cardiometabolic risk in premenopausal black South African (SA) women. METHODS: Changes in body composition and body fat distribution (dual-energy x-ray absorptiometry and computerized tomography), fasting glucose, insulin, and lipid concentrations, were measured in 63 black SA women at baseline (age: 27 ± 8 years), and 5.5 years later. RESULTS: Body weight and fat mass (FM) increased by 6.9 ± 9.9 kg and 4.3 ± 6.9 kg, respectively, over the 5.5 years with a relative (%FM) increase in central and decrease in peripheral FM (all P < 0.05). Fasting glucose and lipid concentrations (except HDL-cholesterol) increased over the follow-up period (all P < 0.05). Both baseline and changes in body fat distribution were associated with cardiometabolic risk. Independent of baseline age, FM and insulin sensitivity, baseline trunk:leg was associated with reduced insulin sensitivity at follow-up (Matsuda index; β = -0.41, P = 0.002). Increasing trunk:gynoid ratio was associated with higher plasma insulin levels (β = 0.31, P = 0.023) and reduced insulin sensitivity (Matsuda index; β = -0.52, P < 0.001) at follow-up. CONCLUSIONS:Weight gain in free-living black SA women over 5.5 years was associated with a centralization of fat mass, which predicted an increase in cardiometabolic risk.
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