Literature DB >> 26311151

Parsing Physiological Functions of Erythropoietin One Domain at a Time.

Lawrence Steinman1.   

Abstract

A domain of erythropoietin (EPO), separate from the domain involved in red blood cell development, has been identified. This region of EPO has anti-inflammatory and neuroprotective effects. Use of a peptide sequence from this region provides the potential for an effective therapeutic without effects on erythropoiesis.

Entities:  

Keywords:  Erythropoietin; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroprotection

Mesh：

Substances：

Year:  2015        PMID： 26311151      PMCID： PMC4604186          DOI： 10.1007/s13311-015-0384-4

Source DB:  PubMed          Journal:  Neurotherapeutics        ISSN： 1878-7479            Impact factor:   7.620


  11 in total

Review 1.  A Distinct Region in Erythropoietin that Induces Immuno/Inflammatory Modulation and Tissue Protection.

Authors:  RuiRong Yuan; Bo Wang; Wei Lu; Yasuhiro Maeda; Peter Dowling
Journal:  Neurotherapeutics       Date:  2015-10       Impact factor: 7.620

Review 2.  No quiet surrender: molecular guardians in multiple sclerosis brain.

Authors:  Lawrence Steinman
Journal:  J Clin Invest       Date:  2015-04-01       Impact factor: 14.808

3.  Beneficial effect of erythropoietin on experimental allergic encephalomyelitis.

Authors:  Weiping Li; Yasuhiro Maeda; Rui Rong Yuan; Stella Elkabes; Stuart Cook; Peter Dowling
Journal:  Ann Neurol       Date:  2004-12       Impact factor: 10.422

4.  Dose-dependent neurorestorative effects of delayed treatment of traumatic brain injury with recombinant human erythropoietin in rats.

Authors:  Yuling Meng; Ye Xiong; Asim Mahmood; Yanlu Zhang; Changsheng Qu; Michael Chopp
Journal:  J Neurosurg       Date:  2011-04-15       Impact factor: 5.115

5.  Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury.

Authors:  M L Brines; P Ghezzi; S Keenan; D Agnello; N C de Lanerolle; C Cerami; L M Itri; A Cerami
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

6.  In vivo evidence that erythropoietin protects neurons from ischemic damage.

Authors:  M Sakanaka; T C Wen; S Matsuda; S Masuda; E Morishita; M Nagao; R Sasaki
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-14       Impact factor: 11.205

Review 7.  Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.

Authors:  K Kevin Pfister
Journal:  Exp Cell Res       Date:  2015-01-06       Impact factor: 3.905

8.  Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

Authors:  May H Han; Sun-Il Hwang; Dolly B Roy; Deborah H Lundgren; Jordan V Price; Shalina S Ousman; Guy Haskin Fernald; Bruce Gerlitz; William H Robinson; Sergio E Baranzini; Brian W Grinnell; Cedric S Raine; Raymond A Sobel; David K Han; Lawrence Steinman
Journal:  Nature       Date:  2008-02-17       Impact factor: 49.962

Review 9.  The pleiotropic effects of erythropoietin in the central nervous system.

Authors:  M Buemi; E Cavallaro; F Floccari; A Sturiale; C Aloisi; M Trimarchi; F Corica; N Frisina
Journal:  J Neuropathol Exp Neurol       Date:  2003-03       Impact factor: 3.685

10.  Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia.

Authors:  Y Wang; Z G Zhang; K Rhodes; M Renzi; R L Zhang; A Kapke; M Lu; C Pool; G Heavner; M Chopp
Journal:  Br J Pharmacol       Date:  2007-07-02       Impact factor: 8.739
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