Samy Boucebci1, Thomas Pambrun2, Stéphane Velasco3, Pier-Olivier Duboe3, Pierre Ingrand4, Jean-Pierre Tasu3. 1. University Hospital, Department of Radiology, University of Poitiers, Poitiers, France. samy@boucebci.com. 2. University Hospital, Department of Cardiology, University of Poitiers, Poitiers, France. 3. University Hospital, Department of Radiology, University of Poitiers, Poitiers, France. 4. University Institute of Public Health, University of Poitiers, Poitiers, France.
Abstract
OBJECTIVES: The aim of this study was to evaluate variations in anatomy and function according to age and gender using cardiac computed tomography (CT) in a large prospective cohort of healthy patients. BACKGROUND: The left atrial appendage (LAA) is considered the most frequent site of intracardiac thrombus formation. However, variations in normal in vivo anatomy and function according to age and gender remain largely unknown. METHODS: Three-dimensional (3D) cardiac reconstructions of the LAA were performed from CT scans of 193 consecutive patients. Parameters measured included LAA number of lobes, anatomical position of the LAA tip, angulation measured between the proximal and distal portions, minimum (iVolmin) and maximum (iVolmax) volumes indexed to body surface area (BSA), and ejection fraction (LAAEF). Relationship with age was assessed for each parameter. RESULTS: We found that men had longer and wider LAAs. The iVolmin and iVolmax increased by 0.23 and 0.19 ml per decade, respectively, while LAAEF decreased by 2% per decade in both sexes. CONCLUSIONS: Although LAA volumes increase, LAAEF decreases with age in both sexes. KEY POINTS: • Variations in normal left atrial appendage in vivo anatomy and function remain largely unknown. • Cardiac CT is reliable for left atrial appendage volume measurements. • Although LAA volumes increase, LAAEF decreases with age in both sexes.
OBJECTIVES: The aim of this study was to evaluate variations in anatomy and function according to age and gender using cardiac computed tomography (CT) in a large prospective cohort of healthy patients. BACKGROUND: The left atrial appendage (LAA) is considered the most frequent site of intracardiac thrombus formation. However, variations in normal in vivo anatomy and function according to age and gender remain largely unknown. METHODS: Three-dimensional (3D) cardiac reconstructions of the LAA were performed from CT scans of 193 consecutive patients. Parameters measured included LAA number of lobes, anatomical position of the LAA tip, angulation measured between the proximal and distal portions, minimum (iVolmin) and maximum (iVolmax) volumes indexed to body surface area (BSA), and ejection fraction (LAAEF). Relationship with age was assessed for each parameter. RESULTS: We found that men had longer and wider LAAs. The iVolmin and iVolmax increased by 0.23 and 0.19 ml per decade, respectively, while LAAEF decreased by 2% per decade in both sexes. CONCLUSIONS: Although LAA volumes increase, LAAEF decreases with age in both sexes. KEY POINTS: • Variations in normal left atrial appendage in vivo anatomy and function remain largely unknown. • Cardiac CT is reliable for left atrial appendage volume measurements. • Although LAA volumes increase, LAAEF decreases with age in both sexes.
Entities:
Keywords:
Anatomy; Computed tomography; Function; Left atrial appendage; Stroke
Authors: T Tabata; T Oki; H Yamada; A Iuchi; S Ito; T Hori; T Kitagawa; I Kato; H Kitahata; S Oshita Journal: Am J Cardiol Date: 1998-02-01 Impact factor: 2.778
Authors: José Ramón López-Mínguez; Reyes González-Fernández; Concepción Fernández-Vegas; Victoria Millán-Nuñez; María Eugenia Fuentes-Cañamero; Juan Manuel Nogales-Asensio; Javier Doncel-Vecino; María Yuste Domínguez; Laura García Serrano; Damián Sánchez Quintana Journal: J Invasive Cardiol Date: 2014-09 Impact factor: 2.022
Authors: T Tabata; T Oki; N Fukuda; A Iuchi; K Manabe; Y Kageji; M Sasaki; H Yamada; S Ito Journal: J Am Soc Echocardiogr Date: 1996 Nov-Dec Impact factor: 5.251
Authors: J A Odell; J L Blackshear; E Davies; W J Byrne; C F Kollmorgen; W D Edwards; T A Orszulak Journal: Ann Thorac Surg Date: 1996-02 Impact factor: 4.330
Authors: Martha Morelos-Guzmán; Larissa Minero-García; José E Jaramillo-Almaguer; José F Chávez-Carbajal; Carlos A Arean-Martínez; Juan M Vargas-Espinosa; Martha E Viveros-Sandoval; Israel D Campos-González Journal: Arch Cardiol Mex Date: 2020-06-18
Authors: Miika Korhonen; Johannes Parkkonen; Marja Hedman; Antti Muuronen; Juha Onatsu; Pirjo Mustonen; Ritva Vanninen; Mikko Taina Journal: PLoS One Date: 2017-03-13 Impact factor: 3.240