Peng Yao1, Yuan-Yuan Ding1, Zhi-Bin Wang1, Jia-Ming Ma1, Tao Hong1, Shi-Nong Pan2. 1. Department of Pain Management, Shengjing Hospital of China Medical University Shenyang 110004, P. R. China. 2. Department of Radiology, Shengjing Hospital of China Medical University Shenyang 110004, P. R. China.
Abstract
OBJECTIVES: To evaluate the effect of COMT and OPRM1 gene polymorphisms on the preoperative pain sensitivity in tumor patients. METHODS: 300 cases of cancer patients undergoing elective surgery were included, and the Val158 Met loci of COMT gene and OPRM1 loci of A118 G gene were genotyped by PCR-RFLP. Pain threshold and pain tolerance threshold were measured using electrical stimulation to investigate the preoperative pain sensitivity in patients with different genotypes. RESULTS: For the COMT gene, the pain threshold and pain tolerance threshold of patients with M allele both decreased (both P < 0.001); for PPRM1 gene, pain threshold and pain tolerance threshold of patients with G allele decreased (both P < 0.001). We also found that there was an interaction between the two genes. CONCLUSION: Gene polymorphisms of COMT and OPRM1 were correlated with the preoperative pain sensitivity of cancer patients. The patients with M allele of COMT and G allele of OPRM1 had higher preoperative pain sensitivity.
OBJECTIVES: To evaluate the effect of COMT and OPRM1 gene polymorphisms on the preoperative pain sensitivity in tumorpatients. METHODS: 300 cases of cancerpatients undergoing elective surgery were included, and the Val158 Met loci of COMT gene and OPRM1 loci of A118 G gene were genotyped by PCR-RFLP. Pain threshold and pain tolerance threshold were measured using electrical stimulation to investigate the preoperative pain sensitivity in patients with different genotypes. RESULTS: For the COMT gene, the pain threshold and pain tolerance threshold of patients with M allele both decreased (both P < 0.001); for PPRM1 gene, pain threshold and pain tolerance threshold of patients with G allele decreased (both P < 0.001). We also found that there was an interaction between the two genes. CONCLUSION: Gene polymorphisms of COMT and OPRM1 were correlated with the preoperative pain sensitivity of cancerpatients. The patients with M allele of COMT and G allele of OPRM1 had higher preoperative pain sensitivity.
Entities:
Keywords:
COMT; Opioid receptors; SNP; Pain measurement; pre-operative care
Authors: Abdullah S Terkawi; William M Jackson; Shehnaz Hansoti; Rabeena Tabassum; Pamela Flood Journal: Anesthesiology Date: 2014-07 Impact factor: 7.892
Authors: Patrick H Finan; Alex J Zautra; Mary C Davis; Kathryn Lemery-Chalfant; Jonathan Covault; Howard Tennen Journal: Pain Date: 2010-12-03 Impact factor: 6.961
Authors: G D Slade; L Diatchenko; K Bhalang; A Sigurdsson; R B Fillingim; I Belfer; M B Max; D Goldman; W Maixner Journal: J Dent Res Date: 2007-11 Impact factor: 6.116
Authors: Jingshan Chen; Barbara K Lipska; Nader Halim; Quang D Ma; Mitsuyuki Matsumoto; Samer Melhem; Bhaskar S Kolachana; Thomas M Hyde; Mary M Herman; Jose Apud; Michael F Egan; Joel E Kleinman; Daniel R Weinberger Journal: Am J Hum Genet Date: 2004-09-27 Impact factor: 11.025
Authors: Heba Khalil; Susan M Sereika; Feng Dai; Sheila Alexander; Yvette Conley; Gary Gruen; Li Meng; Peter Siska; Ivan Tarkin; Richard Henker Journal: Biol Res Nurs Date: 2016-11-30 Impact factor: 2.522
Authors: Jong Y Park; Cecile A Lengacher; Richard R Reich; Carissa B Alinat; Sophia Ramesar; Alice Le; Carly L Paterson; Michelle L Pleasant; Hyun Y Park; John Kiluk; Hyo Han; Roohi Ismail-Khan; Kevin E Kip Journal: Transl Behav Med Date: 2019-07-16 Impact factor: 3.626