Chuangli Wang1, Jianfei Ge1, Shanjun Ni1. 1. Department of Othopedic, The Fist People's Hospital of Zhangjiagang Zhangjiagang 215600, Jiang Su, China.
Abstract
BACKGROUND: Interleukin-6 (IL6) -174C/G polymorphism was suggested to be associated with fracture risk. However, the results were inconsistent. Thus, we did a meta-analysis. METHODS: Reported studies were searched from online electronic databases of Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI). The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to assess the association between IL6 -174C/G polymorphism and fracture risk. RESULTS: Six studies evaluated the association between IL6 -174C/G polymorphism and fracture risk. A significant association was found between IL6 -174C/G polymorphism and fracture risk (OR=1.25; 95% CI, 1.10-1.43; P=0.0008). In the subgroup analysis of gender, we found that women with IL6 -174C/G polymorphism had an increased fracture risk (OR=1.25; 95% CI, 1.07-1.46; P=0.005). In the subgroup analysis of type of fracture, we found that IL6 -174C/G polymorphism was significantly associated with wrist fracture (OR=1.25; 95% CI, 1.07-1.47; P=0.006) and osteoporotic fracture (OR=1.60; 95% CI, 1.12-2.28; P=0.009). However, no significant association was found between IL6 -174C/G polymorphism and hip fracture (OR=1.05; 95% CI, 0.89-1.24; P=0.53) and stress fracture (OR=1.25; 95% CI, 0.97-1.61; P=0.08). CONCLUSION: This meta-analysis suggested that the IL6 -174C/G polymorphism was associated with wrist and osteoporotic fracture risk.
BACKGROUND:Interleukin-6 (IL6) -174C/G polymorphism was suggested to be associated with fracture risk. However, the results were inconsistent. Thus, we did a meta-analysis. METHODS: Reported studies were searched from online electronic databases of Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI). The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to assess the association between IL6-174C/G polymorphism and fracture risk. RESULTS: Six studies evaluated the association between IL6-174C/G polymorphism and fracture risk. A significant association was found between IL6-174C/G polymorphism and fracture risk (OR=1.25; 95% CI, 1.10-1.43; P=0.0008). In the subgroup analysis of gender, we found that women with IL6-174C/G polymorphism had an increased fracture risk (OR=1.25; 95% CI, 1.07-1.46; P=0.005). In the subgroup analysis of type of fracture, we found that IL6-174C/G polymorphism was significantly associated with wrist fracture (OR=1.25; 95% CI, 1.07-1.47; P=0.006) and osteoporotic fracture (OR=1.60; 95% CI, 1.12-2.28; P=0.009). However, no significant association was found between IL6-174C/G polymorphism and hip fracture (OR=1.05; 95% CI, 0.89-1.24; P=0.53) and stress fracture (OR=1.25; 95% CI, 0.97-1.61; P=0.08). CONCLUSION: This meta-analysis suggested that the IL6-174C/G polymorphism was associated with wrist and osteoporotic fracture risk.
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