Siobhan M Phillips1, Elizabeth A Awick2, David E Conroy1, Christine A Pellegrini1, Emily L Mailey3, Edward McAuley2. 1. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 2. Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois. 3. Department of Kinesiology, Kansas State University, Manhattan, Kansas.
Abstract
BACKGROUND: The primary purpose of the current study was to determine prospective associations of accelerometer-assessed physical activity intensity and sedentary time with health-related quality of life (HRQOL) indicators among survivors of breast cancer. METHODS: A total of 358 survivors of breast cancer wore an accelerometer for 7 days at baseline to assess different activity intensities (light, lifestyle, and moderate to vigorous) and sedentary behavior. Six months later, survivors completed online questionnaires that assessed HRQOL indicators (disease-specific HRQOL, fatigue, depression, and anxiety) and relevant covariates. Relationships between activity and sedentary behavior quartiles and HRQOL indicator scores were examined using generalized liner models with Bonferroni multiple comparison adjustment. RESULTS: After adjustment for covariates and sedentary time, each increasing lifestyle activity quartile was associated with reduced fatigue duration (P for trend, .03). Each increasing baseline moderate-to-vigorous physical activity (MVPA) quartile was found to be significantly associated with higher Physical Well-Being, Functional Assessment of Cancer Therapy-Breast (FACT-B) total, and trial outcome index scores; fewer breast cancer-specific concerns; and lower fatigue interference, and these differences were statistically and clinically significant between survivors in quartile 1 and quartile 4. After controlling for covariates and MVPA, relationships between sedentary time and HRQOL were mostly null with the exception of lower fatigue duration. CONCLUSIONS: Objectively measured MVPA was found to be positively associated with many HRQOL indicators. Lifestyle activity was found to be only inversely associated with fatigue duration whereas sedentary time was found to be positively associated with fatigue duration. Future research is warranted to explore these relationships further.
BACKGROUND: The primary purpose of the current study was to determine prospective associations of accelerometer-assessed physical activity intensity and sedentary time with health-related quality of life (HRQOL) indicators among survivors of breast cancer. METHODS: A total of 358 survivors of breast cancer wore an accelerometer for 7 days at baseline to assess different activity intensities (light, lifestyle, and moderate to vigorous) and sedentary behavior. Six months later, survivors completed online questionnaires that assessed HRQOL indicators (disease-specific HRQOL, fatigue, depression, and anxiety) and relevant covariates. Relationships between activity and sedentary behavior quartiles and HRQOL indicator scores were examined using generalized liner models with Bonferroni multiple comparison adjustment. RESULTS: After adjustment for covariates and sedentary time, each increasing lifestyle activity quartile was associated with reduced fatigue duration (P for trend, .03). Each increasing baseline moderate-to-vigorous physical activity (MVPA) quartile was found to be significantly associated with higher Physical Well-Being, Functional Assessment of Cancer Therapy-Breast (FACT-B) total, and trial outcome index scores; fewer breast cancer-specific concerns; and lower fatigue interference, and these differences were statistically and clinically significant between survivors in quartile 1 and quartile 4. After controlling for covariates and MVPA, relationships between sedentary time and HRQOL were mostly null with the exception of lower fatigue duration. CONCLUSIONS: Objectively measured MVPA was found to be positively associated with many HRQOL indicators. Lifestyle activity was found to be only inversely associated with fatigue duration whereas sedentary time was found to be positively associated with fatigue duration. Future research is warranted to explore these relationships further.
Authors: Charles E Matthews; Kong Y Chen; Patty S Freedson; Maciej S Buchowski; Bettina M Beech; Russell R Pate; Richard P Troiano Journal: Am J Epidemiol Date: 2008-02-25 Impact factor: 4.897
Authors: Kristine A Donovan; Paul B Jacobsen; Brent J Small; Pamela N Munster; Michael A Andrykowski Journal: J Pain Symptom Manage Date: 2008-05-20 Impact factor: 3.612
Authors: Nele Devoogdt; Marijke Van Kampen; Inge Geraerts; Tina Coremans; Steffen Fieuws; Johan Lefevre; Renaat Philippaerts; Steven Truijen; Patrick Neven; Marie-Rose Christiaens Journal: Breast Cancer Res Treat Date: 2010-06-27 Impact factor: 4.872
Authors: M J Brady; D F Cella; F Mo; A E Bonomi; D S Tulsky; S R Lloyd; S Deasy; M Cobleigh; G Shiomoto Journal: J Clin Oncol Date: 1997-03 Impact factor: 44.544
Authors: Siobhan M Phillips; Kevin W Dodd; Jeremy Steeves; James McClain; Catherine M Alfano; Edward McAuley Journal: Gynecol Oncol Date: 2015-05-28 Impact factor: 5.482
Authors: Brigid M Lynch; David W Dunstan; Genevieve N Healy; Elisabeth Winkler; Elizabeth Eakin; Neville Owen Journal: Cancer Causes Control Date: 2009-11-01 Impact factor: 2.506
Authors: Stephanie M George; Ashley W Smith; Catherine M Alfano; Heather R Bowles; Melinda L Irwin; Anne McTiernan; Leslie Bernstein; Kathy B Baumgartner; Rachel Ballard-Barbash Journal: J Cancer Surviv Date: 2013-02-02 Impact factor: 4.442
Authors: Richard P Troiano; David Berrigan; Kevin W Dodd; Louise C Mâsse; Timothy Tilert; Margaret McDowell Journal: Med Sci Sports Exerc Date: 2008-01 Impact factor: 5.411
Authors: Rachel Meadows; Timethia Bonner; Megha Dobhal; Sujana Borra; Jordan A Killion; Raheem Paxton Journal: Support Care Cancer Date: 2016-10-05 Impact factor: 3.603
Authors: Maria C Swartz; Zakkoyya H Lewis; Elizabeth J Lyons; Kristofer Jennings; Addie Middleton; Rachel R Deer; Demi Arnold; Kaitlin Dresser; Kenneth J Ottenbacher; James S Goodwin Journal: Arch Phys Med Rehabil Date: 2017-04-17 Impact factor: 3.966
Authors: M A Mahieu; G E Ahn; J S Chmiel; D D Dunlop; I B Helenowski; P Semanik; J Song; S Yount; R W Chang; R Ramsey-Goldman Journal: Lupus Date: 2016-02-10 Impact factor: 2.911
Authors: Sheri J Hartman; Catherine R Marinac; John Bellettiere; Suneeta Godbole; Loki Natarajan; Ruth E Patterson; Jacqueline Kerr Journal: Support Care Cancer Date: 2017-03-22 Impact factor: 3.603
Authors: Avelina C Padin; Stephanie J Wilson; Brittney E Bailey; William B Malarkey; Maryam B Lustberg; William B Farrar; Stephen P Povoski; Doreen M Agnese; Raquel E Reinbolt; Robert Wesolowski; Nicole Williams; Sagar Sardesai; Bhuvaneswari Ramaswamy; Anne M Noonan; Jeffrey B Vandeusen; Garrie J Haas; Janice K Kiecolt-Glaser Journal: Int J Behav Med Date: 2019-06