Kokoro Tsuzaki1, Kazuhiko Kotani2,3, Kazunori Yamada4, Naoki Sakane1. 1. Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. 2. Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. kazukotani@jichi.ac.jp. 3. Division of Community and Family Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp. 4. Diabetes Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Abstract
BACKGROUND: Although a postprandial increment in triglyceride (TG) levels is considered to be a risk factor for atherogenesis, tests (e.g., fat load) to assess postprandial changes in TG levels cannot be easily applied to clinical practice. Therefore, fasting markers that predict postprandial TG states are needed to be developed. One current candidate is lipoprotein lipase (LPL) protein, a molecule that hydrides TGs. This study investigated whether fasting LPL levels could predict postprandial TG levels. METHODS: A total of 17 subjects (11 men, 6 women, mean age 52 ± 11 years) with normotriglyceridemia during fasting underwent the meal test. Several fasting parameters, including LPL, were measured for the area under the curve of postprandial TGs (AUC-TG). RESULTS: The subjects' mean fasting TG level was 1.30 mmol/l, and their mean LPL level was 41.6 ng/ml. The subjects' TG levels increased after loading (they peaked after two postprandial hours). Stepwise multiple regression analysis demonstrated that fasting TG levels were a predictor of the AUC-TG. In addition, fasting LPL mass levels were found to be a predictor of the AUC-TG (β = 0.65, P < 0.01), and this relationship was independent of fasting TG levels. CONCLUSION: Fasting LPL levels may be useful to predict postprandial TG increment in this population.
BACKGROUND: Although a postprandial increment in triglyceride (TG) levels is considered to be a risk factor for atherogenesis, tests (e.g., fat load) to assess postprandial changes in TG levels cannot be easily applied to clinical practice. Therefore, fasting markers that predict postprandial TG states are needed to be developed. One current candidate is lipoprotein lipase (LPL) protein, a molecule that hydrides TGs. This study investigated whether fasting LPL levels could predict postprandial TG levels. METHODS: A total of 17 subjects (11 men, 6 women, mean age 52 ± 11 years) with normotriglyceridemia during fasting underwent the meal test. Several fasting parameters, including LPL, were measured for the area under the curve of postprandial TGs (AUC-TG). RESULTS: The subjects' mean fasting TG level was 1.30 mmol/l, and their mean LPL level was 41.6 ng/ml. The subjects' TG levels increased after loading (they peaked after two postprandial hours). Stepwise multiple regression analysis demonstrated that fasting TG levels were a predictor of the AUC-TG. In addition, fasting LPL mass levels were found to be a predictor of the AUC-TG (β = 0.65, P < 0.01), and this relationship was independent of fasting TG levels. CONCLUSION: Fasting LPL levels may be useful to predict postprandial TG increment in this population.
Authors: P H Groot; W A van Stiphout; X H Krauss; H Jansen; A van Tol; E van Ramshorst; S Chin-On; A Hofman; S R Cresswell; L Havekes Journal: Arterioscler Thromb Date: 1991 May-Jun
Authors: Milène Catoire; Sheril Alex; Nicolas Paraskevopulos; Frits Mattijssen; Inkie Evers-van Gogh; Gert Schaart; Jacob Jeppesen; Anita Kneppers; Marco Mensink; Peter J Voshol; Gunilla Olivecrona; Nguan Soon Tan; Matthijs K C Hesselink; Jimmy F Berbée; Patrick C N Rensen; Eric Kalkhoven; Patrick Schrauwen; Sander Kersten Journal: Proc Natl Acad Sci U S A Date: 2014-03-03 Impact factor: 11.205