Syuichi Ooki1. 1. Department of Health Science, Ishikawa Prefectural Nursing University, 1-1 Gakuendai, Kahoku, Ishikawa, 929-1210, Japan. sooki@ishikawa-nu.ac.jp.
Abstract
OBJECTIVES: The purpose of the present study was to analyze birth defects (congenital anomalies) after assisted reproductive technology (ART) according to the method of treatment, namely in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and frozen-thawed embryo transfer (FET). METHODS: Individual lists of all ART pregnancies resulting in birth defects from birth year 2004 to 2012 presented in the annual reports by the Japan Society of Obstetrics and Gynecology were used as the initial sources of information. Relative risks (RRs) with the corresponding 95 % confidence intervals (CIs) were calculated with IVF as the reference group when calculating RR of ICSI for IVF, and with FET as the reference group when calculating the RR of fresh embryo transfer for FET. RESULTS: In total, 2725 stillbirths or live births with birth defects were analyzed. The prevalence of birth defects was slightly yet significantly higher in ICSI compared with IVF throughout the study period (RR = 1.15, 95 % CI 1.02-1.29) and in the 2004-2006 period (RR = 1.26, 95 % CI 1.00-1.58). The prevalence of birth defects was significantly higher for fresh embryo transfer compared with FET in the 2004-2006 period (RR = 1.39, 95 % CI 1.12-1.72). The prevalence of birth defects in multiple births was significantly lower in fresh embryo transfer compared with FET (RR = 0.70, 95 % CI 0.55-0.90, live births of 2007-2012). CONCLUSIONS: The present descriptive epidemiological study suggests that the impacts of different ART methods on birth defects might differ.
OBJECTIVES: The purpose of the present study was to analyze birth defects (congenital anomalies) after assisted reproductive technology (ART) according to the method of treatment, namely in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) and frozen-thawed embryo transfer (FET). METHODS: Individual lists of all ART pregnancies resulting in birth defects from birth year 2004 to 2012 presented in the annual reports by the Japan Society of Obstetrics and Gynecology were used as the initial sources of information. Relative risks (RRs) with the corresponding 95 % confidence intervals (CIs) were calculated with IVF as the reference group when calculating RR of ICSI for IVF, and with FET as the reference group when calculating the RR of fresh embryo transfer for FET. RESULTS: In total, 2725 stillbirths or live births with birth defects were analyzed. The prevalence of birth defects was slightly yet significantly higher in ICSI compared with IVF throughout the study period (RR = 1.15, 95 % CI 1.02-1.29) and in the 2004-2006 period (RR = 1.26, 95 % CI 1.00-1.58). The prevalence of birth defects was significantly higher for fresh embryo transfer compared with FET in the 2004-2006 period (RR = 1.39, 95 % CI 1.12-1.72). The prevalence of birth defects in multiple births was significantly lower in fresh embryo transfer compared with FET (RR = 0.70, 95 % CI 0.55-0.90, live births of 2007-2012). CONCLUSIONS: The present descriptive epidemiological study suggests that the impacts of different ART methods on birth defects might differ.
Entities:
Keywords:
Birth defects; Frozen-thawed embryo transfer (FET); In vitro fertilization (IVF); Intracytoplasmic sperm injection (ICSI); Nationwide multi-year data
Authors: Christine K Olson; Kim M Keppler-Noreuil; Paul A Romitti; William T Budelier; Ginny Ryan; Amy E T Sparks; Bradley J Van Voorhis Journal: Fertil Steril Date: 2005-11 Impact factor: 7.329
Authors: Michael J Davies; Vivienne M Moore; Kristyn J Willson; Phillipa Van Essen; Kevin Priest; Heather Scott; Eric A Haan; Annabelle Chan Journal: N Engl J Med Date: 2012-05-05 Impact factor: 91.245
Authors: Michèle Hansen; Carol Bower; Elizabeth Milne; Nicholas de Klerk; Jennifer J Kurinczuk Journal: Hum Reprod Date: 2004-11-26 Impact factor: 6.918
Authors: F Belva; S Henriet; E Van den Abbeel; M Camus; P Devroey; J Van der Elst; I Liebaers; P Haentjens; M Bonduelle Journal: Hum Reprod Date: 2008-07-14 Impact factor: 6.918
Authors: U-B Wennerholm; V Söderström-Anttila; C Bergh; K Aittomäki; J Hazekamp; K-G Nygren; A Selbing; A Loft Journal: Hum Reprod Date: 2009-05-20 Impact factor: 6.918
Authors: Bengt Källén; Orvar Finnström; Anna Lindam; Emma Nilsson; Karl-Gösta Nygren; Petra Olausson Otterblad Journal: Birth Defects Res A Clin Mol Teratol Date: 2010-03