Literature DB >> 26296098

Targeting breast cancer with sugar-coated carbon nanotubes.

Cale D Fahrenholtz1, Mallinath Hadimani2, S Bruce King2, Suzy V Torti3, Ravi Singh1,4.   

Abstract

AIMS: To evaluate the use of glucosamine functionalized multiwalled carbon nanotubes (glyco-MWCNTs) for breast cancer targeting. MATERIALS &
METHODS: Two types of glucosamine functionalized MWCNTs were developed (covalently linked glucosamine and non-covalently phospholipid-glucosamine coated) and evaluated for their potential to bind and target breast cancer cells in vitro and in vivo. RESULTS &
CONCLUSION: Binding of glyco-MWCNTs in breast cancer cells is mediated by specific interaction with glucose transporters. Glyco-MWCNTs prepared by non-covalent coating with phospholipid-glucosamine displayed an extended blood circulation time, delayed urinary clearance, low tissue retention and increased breast cancer tumor accumulation in vivo. These studies lay the foundation for development of a cancer diagnostic agent based upon glyco-MWCNTs with the potential for superior accuracy over current radiopharmaceuticals.

Entities:  

Keywords:  biocompatibility; imaging; metabolism; nanoparticle; self-assembly

Mesh：

Substances：

Year:  2015        PMID： 26296098      PMCID： PMC4610120          DOI： 10.2217/NNM.15.90

Source DB:  PubMed          Journal:  Nanomedicine (Lond)        ISSN： 1743-5889            Impact factor:   5.307


  59 in total

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