Literature DB >> 26294738

Karyotype evolution and acquisition of FLT3 or RAS pathway alterations drive progression of myelodysplastic syndrome to acute myeloid leukemia.

Manja Meggendorfer1, Andreia de Albuquerque1, Niroshan Nadarajah1, Tamara Alpermann1, Wolfgang Kern1, Kimberly Steuer1, Karolína Perglerová2, Claudia Haferlach1, Susanne Schnittger1, Torsten Haferlach3.   

Abstract

Entities:  

Keywords:  MDS; mutation analysis; s-AML

Mesh：

Substances：

Year:  2015        PMID： 26294738      PMCID： PMC4666337          DOI： 10.3324/haematol.2015.127985

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  14 in total

1.  Mutation analysis for RUNX1, MLL-PTD, FLT3-ITD, NPM1 and NRAS in 269 patients with MDS or secondary AML.

Authors:  F Dicker; C Haferlach; J Sundermann; N Wendland; T Weiss; W Kern; T Haferlach; S Schnittger
Journal:  Leukemia       Date:  2010-06-03       Impact factor: 11.528

2.  Implications of NRAS mutations in AML: a study of 2502 patients.

Authors:  Ulrike Bacher; Torsten Haferlach; Claudia Schoch; Wolfgang Kern; Susanne Schnittger
Journal:  Blood       Date:  2006-01-24       Impact factor: 22.113

3.  Chromosomal alterations associated with evolution from myelodysplastic syndrome to acute myeloid leukemia.

Authors:  T de Souza Fernandez; M H Ornellas; L Otero de Carvalho; D Tabak; E Abdelhay
Journal:  Leuk Res       Date:  2000-10       Impact factor: 3.156

4.  Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.

Authors:  Felicitas Thol; Sofia Kade; Carola Schlarmann; Patrick Löffeld; Michael Morgan; Jürgen Krauter; Marcin W Wlodarski; Britta Kölking; Martin Wichmann; Kerstin Görlich; Gudrun Göhring; Gesine Bug; Oliver Ottmann; Charlotte M Niemeyer; Wolf-Karsten Hofmann; Brigitte Schlegelberger; Arnold Ganser; Michael Heuser
Journal:  Blood       Date:  2012-03-02       Impact factor: 22.113

5.  FLT3 and NPM1 mutations in myelodysplastic syndromes: Frequency and potential value for predicting progression to acute myeloid leukemia.

Authors:  Ashish Bains; Rajyalakshmi Luthra; L Jeffrey Medeiros; Zhuang Zuo
Journal:  Am J Clin Pathol       Date:  2011-01       Impact factor: 2.493

6.  Clinical effect of point mutations in myelodysplastic syndromes.

Authors:  Rafael Bejar; Kristen Stevenson; Omar Abdel-Wahab; Naomi Galili; Björn Nilsson; Guillermo Garcia-Manero; Hagop Kantarjian; Azra Raza; Ross L Levine; Donna Neuberg; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2011-06-30       Impact factor: 91.245

7.  Frequent pathway mutations of splicing machinery in myelodysplasia.

Authors:  Kenichi Yoshida; Masashi Sanada; Yuichi Shiraishi; Daniel Nowak; Yasunobu Nagata; Ryo Yamamoto; Yusuke Sato; Aiko Sato-Otsubo; Ayana Kon; Masao Nagasaki; George Chalkidis; Yutaka Suzuki; Masashi Shiosaka; Ryoichiro Kawahata; Tomoyuki Yamaguchi; Makoto Otsu; Naoshi Obara; Mamiko Sakata-Yanagimoto; Ken Ishiyama; Hiraku Mori; Florian Nolte; Wolf-Karsten Hofmann; Shuichi Miyawaki; Sumio Sugano; Claudia Haferlach; H Phillip Koeffler; Lee-Yung Shih; Torsten Haferlach; Shigeru Chiba; Hiromitsu Nakauchi; Satoru Miyano; Seishi Ogawa
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

8.  Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia.

Authors:  L-Y Shih; C-F Huang; P-N Wang; J-H Wu; T-L Lin; P Dunn; M-C Kuo
Journal:  Leukemia       Date:  2004-03       Impact factor: 11.528

9.  Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.

Authors:  Susanne Schnittger; Claudia Schoch; Martin Dugas; Wolfgang Kern; Peter Staib; Christian Wuchter; Helmut Löffler; Cristina Maria Sauerland; Hubert Serve; Thomas Büchner; Torsten Haferlach; Wolfgang Hiddemann
Journal:  Blood       Date:  2002-07-01       Impact factor: 22.113

10.  Acquisition of cytogenetic abnormalities in patients with IPSS defined lower-risk myelodysplastic syndrome is associated with poor prognosis and transformation to acute myelogenous leukemia.

Authors:  Elias Jabbour; Koichi Takahashi; Xuemei Wang; A Megan Cornelison; Lynne Abruzzo; Tapan Kadia; Gautam Borthakur; Zeev Estrov; Susan O'Brien; Mar Mallo; William Wierda; Sherry Pierce; Yue Wei; Francisco Sole; Rui Chen; Hagop Kantarjian; Guillermo Garcia-Manero
Journal:  Am J Hematol       Date:  2013-07-23       Impact factor: 10.047
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  16 in total

Review 1.  Somatic SETBP1 mutations in myeloid neoplasms.

Authors:  Hideki Makishima
Journal:  Int J Hematol       Date:  2017-04-26       Impact factor: 2.490

2.  The clonal origins of leukemic progression of myelodysplasia.

Authors:  T Kim; M S Tyndel; H J Kim; J-S Ahn; S H Choi; H J Park; Y-K Kim; D-H Yang; J-J Lee; S-H Jung; S Y Kim; Y H Min; J-W Cheong; S K Sohn; J H Moon; M Choi; M Lee; Z Zhang; D D H Kim
Journal:  Leukemia       Date:  2017-01-16       Impact factor: 11.528

3.  Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity.

Authors:  Bonnie W Lau; Kyounghee Huh; Rafael Madero-Marroquin; Federico De Marchi; Yiting Lim; Qiuju Wang; Francisco Lobo; Luigi Marchionni; Douglas B Smith; Amy DeZern; Mark J Levis; Peter D Aplan; William Matsui; Lukasz P Gondek
Journal:  Oncogene       Date:  2018-08-31       Impact factor: 9.867

4.  Allogeneic hematopoietic cell transplantation can overcome the adverse prognosis indicated by secondary-type mutations in de novo acute myeloid leukemia.

Authors:  Ga-Young Song; TaeHyung Kim; Seo-Yeon Ahn; Sung-Hoon Jung; Mihee Kim; Deok-Hwan Yang; Je-Jung Lee; Seung Hyun Choi; Mi Yeon Kim; Chul Won Jung; Jun-Ho Jang; Hee Je Kim; Joon Ho Moon; Sang Kyun Sohn; Jong-Ho Won; Seong-Kyu Park; Sung-Hyun Kim; Zhaolei Zhang; Jae-Sook Ahn; Hyeoung-Joon Kim; Dennis Dong Hwan Kim
Journal:  Bone Marrow Transplant       Date:  2022-09-23       Impact factor: 5.174

5.  Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.

Authors:  Yotaro Ochi; Ayana Kon; Toyonori Sakata; Masahiro M Nakagawa; Naotaka Nakazawa; Masanori Kakuta; Keisuke Kataoka; Haruhiko Koseki; Manabu Nakayama; Daisuke Morishita; Tatsuaki Tsuruyama; Ryunosuke Saiki; Akinori Yoda; Rurika Okuda; Tetsuichi Yoshizato; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Shinichi Kotani; Yasunori Kogure; Nobuyuki Kakiuchi; Tomomi Nishimura; Hideki Makishima; Luca Malcovati; Akihiko Yokoyama; Kengo Takeuchi; Eiji Sugihara; Taka-Aki Sato; Masashi Sanada; Akifumi Takaori-Kondo; Mario Cazzola; Mineko Kengaku; Satoru Miyano; Katsuhiko Shirahige; Hiroshi I Suzuki; Seishi Ogawa
Journal:  Cancer Discov       Date:  2020-04-05       Impact factor: 39.397

6.  Acute myeloid leukemia in the era of precision medicine: recent advances in diagnostic classification and risk stratification.

Authors:  Rina Kansal
Journal:  Cancer Biol Med       Date:  2016-03       Impact factor: 4.248

7.  Molecular analysis of myelodysplastic syndrome with isolated deletion of the long arm of chromosome 5 reveals a specific spectrum of molecular mutations with prognostic impact: a study on 123 patients and 27 genes.

Authors:  Manja Meggendorfer; Claudia Haferlach; Wolfgang Kern; Torsten Haferlach
Journal:  Haematologica       Date:  2017-06-22       Impact factor: 9.941

8.  Clonal evolution in myelodysplastic syndromes.

Authors:  Pedro da Silva-Coelho; Leonie I Kroeze; Kenichi Yoshida; Theresia N Koorenhof-Scheele; Ruth Knops; Louis T van de Locht; Aniek O de Graaf; Marion Massop; Sarah Sandmann; Martin Dugas; Marian J Stevens-Kroef; Jaroslav Cermak; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Theo de Witte; Nicole M A Blijlevens; Petra Muus; Gerwin Huls; Bert A van der Reijden; Seishi Ogawa; Joop H Jansen
Journal:  Nat Commun       Date:  2017-04-21       Impact factor: 14.919

9.  Large-scale gene network analysis reveals the significance of extracellular matrix pathway and homeobox genes in acute myeloid leukemia: an introduction to the Pigengene package and its applications.

Authors:  Amir Foroushani; Rupesh Agrahari; Roderick Docking; Linda Chang; Gerben Duns; Monika Hudoba; Aly Karsan; Habil Zare
Journal:  BMC Med Genomics       Date:  2017-03-16       Impact factor: 3.063

Review 10.  Molecular and Cellular Mechanisms of Myelodysplastic Syndrome: Implications on Targeted Therapy.

Authors:  Harinder Gill; Anskar Y H Leung; Yok-Lam Kwong
Journal:  Int J Mol Sci       Date:  2016-03-24       Impact factor: 5.923
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