Yin Cao1, Jeffrey A Meyerhardt2, Andrew T Chan3,4, Kana Wu5, Charles S Fuchs2,3, Edward L Giovannucci5,3,6. 1. Department of Nutrition, Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. yic576@mail.harvard.edu. 2. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. 3. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 4. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 5. Department of Nutrition, Harvard T. H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA. 6. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Abstract
PURPOSE: To assess the association between pre- and postdiagnostic time spent sitting watching TV as well as other sedentary behaviors (other sitting at home and at work/driving) and mortality from colorectal cancer or other causes, and overall mortality. METHODS: We followed stage I-III colorectal cancer patients from the Health Professionals Follow-up Study (1986-2010). Cox models were used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs). RESULTS: A total of 926 and 714 patients were included in the analysis of pre- and postdiagnostic TV watching, respectively, and 471 and 325 died during follow-up. Prolonged prediagnostic TV viewing was associated with increased risk of colorectal cancer-specific mortality independent of leisure-time physical activity. The HRs (95 % CIs) for 0-6, 7-13, 14-20, and ≥21 h/week were 1.00 (referent), 0.84 (0.56-1.25), 1.15 (0.75-1.78), and 2.13 (1.31-3.45) (p trend = 0.01). The association was observed primarily among overweight and obese individuals. Prediagnostic TV watching was also associated with overall mortality within 5 years of diagnosis, largely due to the association with colorectal cancer mortality. Other prediagnostic sitting at home or at work/driving was not associated with mortality. Postdiagnostic TV viewing was associated with a nonsignificantly increased risk of colorectal cancer-specific mortality (HR for ≥21 vs 0-6 h/week = 1.45; 95 % CI 0.73-2.87) adjusting for TV viewing before diagnosis. CONCLUSION: Prolonged prediagnostic TV watching is associated with higher colorectal cancer-specific mortality independent of leisure-time physical activity among colorectal cancer patients.
PURPOSE: To assess the association between pre- and postdiagnostic time spent sitting watching TV as well as other sedentary behaviors (other sitting at home and at work/driving) and mortality from colorectal cancer or other causes, and overall mortality. METHODS: We followed stage I-III colorectal cancerpatients from the Health Professionals Follow-up Study (1986-2010). Cox models were used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs). RESULTS: A total of 926 and 714 patients were included in the analysis of pre- and postdiagnostic TV watching, respectively, and 471 and 325 died during follow-up. Prolonged prediagnostic TV viewing was associated with increased risk of colorectal cancer-specific mortality independent of leisure-time physical activity. The HRs (95 % CIs) for 0-6, 7-13, 14-20, and ≥21 h/week were 1.00 (referent), 0.84 (0.56-1.25), 1.15 (0.75-1.78), and 2.13 (1.31-3.45) (p trend = 0.01). The association was observed primarily among overweight and obese individuals. Prediagnostic TV watching was also associated with overall mortality within 5 years of diagnosis, largely due to the association with colorectal cancer mortality. Other prediagnostic sitting at home or at work/driving was not associated with mortality. Postdiagnostic TV viewing was associated with a nonsignificantly increased risk of colorectal cancer-specific mortality (HR for ≥21 vs 0-6 h/week = 1.45; 95 % CI 0.73-2.87) adjusting for TV viewing before diagnosis. CONCLUSION: Prolonged prediagnostic TV watching is associated with higher colorectal cancer-specific mortality independent of leisure-time physical activity among colorectal cancerpatients.
Entities:
Keywords:
Colorectal cancer; Sedentary behavior; Survival; Television watching
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